Categoria 2 do AREDS (Age-Related Eye Disease Study Group) (degeneração macular relacionada à idade [DMRI] precoce)
Geralmente, a acuidade visual permanece não afetada, a menos que ocorra progressão.
Os pacientes têm um risco de 1.3% ao longo de 5 anos de evoluírem para DMRI tardia.[52]Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/268224
http://www.ncbi.nlm.nih.gov/pubmed/11594942?tool=bestpractice.com
Nenhum tratamento demonstrou ser eficaz para essa categoria da doença.[40]American Academy of Ophthalmology. Preferred practice pattern: retina summary benchmarks - 2024. Dec 2024 [internet publication].
https://www.aao.org/education/summary-benchmark-detail/retina-summary-benchmarks-2020
Categoria 3 do AREDS (DMRI intermediária)
Geralmente, a acuidade visual permanece não afetada, a menos que ocorra progressão.
Em um estudo, pacientes com DMRI intermediária apresentaram um risco de 18% de evoluir para DMRI tardia ao longo de 5 anos.[52]Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/268224
http://www.ncbi.nlm.nih.gov/pubmed/11594942?tool=bestpractice.com
Outro estudo constatou que as taxas de progressão para DMRI exsudativa em 5 e 10 anos em pacientes com DMRI intermediária foram de 14.8% e 28.4%, respectivamente.[113]Joo K, Mun YS, Park SJ, et al. Ten-year progression from intermediate to exudative age-related macular degeneration and risk factors: bundang AMD cohort study report 1. Am J Ophthalmol. 2021 Apr;224:228-37.
http://www.ncbi.nlm.nih.gov/pubmed/33279454?tool=bestpractice.com
Categoria 4 do AREDS (DMRI tardia)
Os pacientes com doença unilateral têm uma chance de 43% ao longo de 5 anos de desenvolver DMRI tardia no outro olho.[52]Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/268224
http://www.ncbi.nlm.nih.gov/pubmed/11594942?tool=bestpractice.com
A DMRI (seca) com atrofia geográfica tende a resultar em menor comprometimento visual que a DMRI exsudativa (úmida). Em contraste, a DMRI úmida, se não tratada, resultará em perda da visão significativa (duplicação do ângulo visual ou pior) em mais da metade dos pacientes ao longo dos próximos anos.[104]Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Arch Ophthalmol. 1991 Aug;109(8):1109-14.
http://www.ncbi.nlm.nih.gov/pubmed/1714270?tool=bestpractice.com
[105]Macular Photocoagulation Study Group. Laser photocoagulation for juxtafoveal choroidal neovascularization. Five-year results from randomized clinical trials. Arch Ophthalmol. 1994 Apr;112(4):500-9.
http://www.ncbi.nlm.nih.gov/pubmed/7512336?tool=bestpractice.com
[114]Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Arch Ophthalmol. 1991 Sep;109(9):1220-31.
http://www.ncbi.nlm.nih.gov/pubmed/1718250?tool=bestpractice.com
[115]Sunness JS, Rubin GS, Applegate CA, et al. Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology. 1997 Oct;104(10):1677-91.
http://www.ncbi.nlm.nih.gov/pubmed/9331210?tool=bestpractice.com
Em um estudo com pacientes com atrofia geográfica, 13.8% dos pacientes desenvolveram DMRI exsudativa durante um período médio de acompanhamento de 4.1 anos.[116]Hwang CK, Agrón E, Domalpally A, et al. Progression of geographic atrophy with subsequent exudative neovascular disease in age-related macular degeneration: AREDS2 report 24. Ophthalmol Retina. 2021 Feb;5(2):108-17.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7870515
http://www.ncbi.nlm.nih.gov/pubmed/33075546?tool=bestpractice.com
Em pacientes com neovascularização secundária à DMRI tratados com inibidores do fator de crescimento endotelial vascular (VEGF) (ranibizumabe ou bevacizumabe), a proporção de pacientes com acuidade visual de 20/200 ou pior foi de 6% na avaliação basal, 5% após 2 anos e 20% após 5 anos.[117]Maguire MG, Martin DF, Ying GS, et al.; Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group. Five-year outcomes with anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration: the comparison of age-related macular degeneration treatments trials. Ophthalmology. 2016 Aug;123(8):1751-61.
https://www.aaojournal.org/article/S0161-6420(16)30092-6/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/27156698?tool=bestpractice.com