O rinovírus tem sido cada vez mais estudado e demonstrado uma associação com sibilância recorrente e um diagnóstico de asma.[139]Mansbach JM, Camargo CA Jr. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med. 2009 Dec;29(4):741-55.
http://www.ncbi.nlm.nih.gov/pubmed/19892232?tool=bestpractice.com
[140]Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178:667-72.
https://www.atsjournals.org/doi/full/10.1164/rccm.200802-309OC
http://www.ncbi.nlm.nih.gov/pubmed/18565953?tool=bestpractice.com
[141]Lukkarinen M, Koistinen A, Turunen R, et al. Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age. J Allergy Clin Immunol. 2017 Oct;140(4):988-95.
http://www.ncbi.nlm.nih.gov/pubmed/28347734?tool=bestpractice.com
[142]Törmänen S, Lauhkonen E, Riikonen R, et al. Risk factors for asthma after infant bronchiolitis. Allergy. 2018 Apr;73(4):916-22.
http://www.ncbi.nlm.nih.gov/pubmed/29105099?tool=bestpractice.com
[143]Midulla F, Nicolai A, Ferrara M, et al. Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections and blood eosinophilia. Acta Paediatr. 2014 Oct;103(10):1094-9.
http://www.ncbi.nlm.nih.gov/pubmed/24948158?tool=bestpractice.com
Fatores de risco como ter história familiar de asma aumentam o risco de um diagnóstico de asma futura.[140]Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178:667-72.
https://www.atsjournals.org/doi/full/10.1164/rccm.200802-309OC
http://www.ncbi.nlm.nih.gov/pubmed/18565953?tool=bestpractice.com
[144]Brandão HV, Vieira GO, Vieira TO, et al. Acute viral bronchiolitis and risk of asthma in schoolchildren: analysis of a Brazilian newborn cohort. J Pediatr (Rio J). 2017 May - Jun;93(3):223-9.
https://www.sciencedirect.com/science/article/pii/S002175571630119X?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/27665269?tool=bestpractice.com
Um grande estudo retrospectivo de base populacional realizado na Espanha descobriu que a taxa de sibilância recorrente ou asma foi maior quando a bronquiolite ocorreu após os primeiros 6 meses de vida.[145]Muñoz-Quiles C, López-Lacort M, Díez-Domingo J, et al. Bronchiolitis, regardless of its etiology and severity, is associated with increased risk of asthma: a population-based study. J Infect Dis. 2023 Oct 3;228(7):840-50.
https://academic.oup.com/jid/article/228/7/840/7104078
http://www.ncbi.nlm.nih.gov/pubmed/37015894?tool=bestpractice.com
Os etudos não conseguiram esclarecer se a bronquiolite viral e/ou por VSR contribui para o desenvolvimento de asma ou serve como marcador clínico de uma predisposição genética para a asma.[146]Wu P, Dupont WD, Griffin MR, et al. Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med. 2008 Dec 1;178(11):1123-9.
http://www.ncbi.nlm.nih.gov/pubmed/18776151?tool=bestpractice.com
[147]Thomsen SF, van der Sluis S, Stensballe LG, et al. Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am J Respir Crit Care Med. 2009 Jun 15;179(12):1091-7.
http://www.ncbi.nlm.nih.gov/pubmed/19286626?tool=bestpractice.com
Asma em crianças