As evidências contemporâneas sobre a epidemiologia da asma ocupacional (AO) são limitadas.[5]Murgia N, Akgun M, Blanc PD, et al. Issue 3-the occupational burden of respiratory diseases, an update. Pulmonology. 2025 Dec 31;31(1):2416808.
https://www.sciencedirect.com/science/article/pii/S253104372400045X
http://www.ncbi.nlm.nih.gov/pubmed/38704309?tool=bestpractice.com
Nos EUA, a incidência de AO é estimada em 179 por milhão de pessoas por ano.[6]Mazurek JM, Knoeller GE, Moorman JE, et al. Occupational asthma incidence: findings from the behavioral risk factor surveillance system asthma call-back survey--United States, 2006-2009. J Asthma. 2013 May;50(4):390-4.
http://www.ncbi.nlm.nih.gov/pubmed/23394187?tool=bestpractice.com
[7]Mapp CE, Boschetto P, Maestrelli P, et al. Occupational asthma. Am J Respir Crit Care Med. 2005 Aug 1;172(3):280-305.
https://www.atsjournals.org/doi/10.1164/rccm.200311-1575SO
http://www.ncbi.nlm.nih.gov/pubmed/15860754?tool=bestpractice.com
A incidência estimada é de 20 a 40 por milhão de pessoas por ano no Reino Unido e 187 por milhão por ano na Finlândia.[8]McDonald JC, Chen Y, Zekveld C, et al. Incidence by occupation and industry of acute work related respiratory diseases in the UK, 1992-2001. Occup Environ Med. 2005 Dec;62(12):836-42.
http://www.ncbi.nlm.nih.gov/pubmed/16299091?tool=bestpractice.com
[9]Kogevinas M, Zock JP, Jarvis D, et al. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet. 2007 Jul 28;370(9584):336-41.
http://www.ncbi.nlm.nih.gov/pubmed/17662882?tool=bestpractice.com
[10]Karjalainen A, Kurppa K, Martikainen R, et al. Work is related to a substantial portion of adult-onset asthma incidence in the Finnish population. Am J Respir Crit Care Med. 2001 Aug 15;164(4):565-8.
http://www.ncbi.nlm.nih.gov/pubmed/11520716?tool=bestpractice.com
As diferenças na incidência de AO podem se relacionar à variabilidade das indústrias locais, aos critérios de diagnóstico e às fontes usadas para gerar dados, como fontes de indenização trabalhistas, programas de vigilância ou estudos populacionais.
Aproximadamente 13% a 16% dos casos de asma em países industrializados (ou em rápida industrialização) podem ser atribuídos a exposições ocupacionais.[11]Torén K, Blanc PD. Asthma caused by occupational exposures is common: a systematic analysis of estimates of the population-attributable fraction. BMC Pulm Med. 2009 Jan 29:9:7.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642762
http://www.ncbi.nlm.nih.gov/pubmed/19178702?tool=bestpractice.com
[12]Jeebhay MF, Quirce S. Occupational asthma in the developing and industrialised world: a review. Int J Tuberc Lung Dis. 2007 Feb;11(2):122-33.
http://www.ingentaconnect.com/content/iuatld/ijtld/2007/00000011/00000002/art00003
http://www.ncbi.nlm.nih.gov/pubmed/17263280?tool=bestpractice.com
Na Zâmbia, um país menos industrializado, apenas 6% dos pacientes adultos diagnosticados com asma apresentavam AO.[13]Syabbalo N. Occupational asthma in a developing country. Chest. 1991 Feb;99(2):528.
https://journal.chestnet.org/article/S0012-3692(16)48897-5/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/1989836?tool=bestpractice.com
Na Europa, houve um declínio notável na incidência de AO desde 2000, com a maior parte da diminuição ocorrendo antes de 2007.[14]Stocks SJ, McNamee R, van der Molen HF, et al. Trends in incidence of occupational asthma, contact dermatitis, noise-induced hearing loss, carpal tunnel syndrome and upper limb musculoskeletal disorders in European countries from 2000 to 2012. Occup Environ Med. 2015 Apr;72(4):294-303.
https://oem.bmj.com/content/72/4/294.long
http://www.ncbi.nlm.nih.gov/pubmed/25575531?tool=bestpractice.com
[15]Seed MJ, Carder M, Gittins M, et al. Emerging trends in the UK incidence of occupational asthma: should we be worried? Occup Environ Med. 2019 Jun;76(6):396-7.
http://www.ncbi.nlm.nih.gov/pubmed/30936407?tool=bestpractice.com
Isto deve-se provavelmente a iniciativas estratégicas europeias que visam reduzir as exposições relevantes para a asma.
A distribuição entre sexos da AO deve-se basicamente a diferenças de ocupações e, portanto, ao tipo de exposição.[16]Wai Y, Tarlo SM. Occupational lung disease in women. In: Buist S, Mapp CE, ed.Respiratory diseases in women. European Respiratory Monograph, vol 8, no 25.Lausanne, Switzerland: European Respiratory Society; 2003:131-46. Maior exposição a produtos de limpeza, têxteis e agentes biológicos é relatada em mulheres. Entretanto, nos homens, há registro de aumento do risco de asma associado à farinha e a fumos de soldagem.
O risco de AO depende da ocupação e da exposição
As ocupações de risco comumente relatadas incluem tecnologia de saúde animal, assistência médica, panificação, pintura de automóveis, enfermagem, marcenaria, limpeza e cabeleireiro.[8]McDonald JC, Chen Y, Zekveld C, et al. Incidence by occupation and industry of acute work related respiratory diseases in the UK, 1992-2001. Occup Environ Med. 2005 Dec;62(12):836-42.
http://www.ncbi.nlm.nih.gov/pubmed/16299091?tool=bestpractice.com
[9]Kogevinas M, Zock JP, Jarvis D, et al. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet. 2007 Jul 28;370(9584):336-41.
http://www.ncbi.nlm.nih.gov/pubmed/17662882?tool=bestpractice.com
[10]Karjalainen A, Kurppa K, Martikainen R, et al. Work is related to a substantial portion of adult-onset asthma incidence in the Finnish population. Am J Respir Crit Care Med. 2001 Aug 15;164(4):565-8.
http://www.ncbi.nlm.nih.gov/pubmed/11520716?tool=bestpractice.com
[17]Gautrin D, Infante-Rivard C, Ghezzo H, et al. Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals. Am J Respir Crit Care Med. 2001 Mar;163(4):899-904.
https://www.atsjournals.org/doi/10.1164/ajrccm.163.4.2008011
http://www.ncbi.nlm.nih.gov/pubmed/11282763?tool=bestpractice.com
[18]Vizcaya D, Mirabelli MC, Gimeno D, et al. Cleaning products and short-term respiratory effects among female cleaners with asthma. Occup Environ Med. 2015 Nov;72(11):757-63.
http://www.ncbi.nlm.nih.gov/pubmed/25907212?tool=bestpractice.com
[19]Macan J, Babić Ž, Hallmann S, et al. Respiratory toxicity of persulphate salts and their adverse effects on airways in hairdressers: a systematic review. Int Arch Occup Environ Health. 2022 Oct;95(8):1679-702.
https://link.springer.com/article/10.1007/s00420-022-01852-w
http://www.ncbi.nlm.nih.gov/pubmed/35316371?tool=bestpractice.com
[20]Garrido AN, House R, Lipszyc JC, et al. Cleaning agent usage in healthcare professionals and relationship to lung and skin symptoms. J Asthma. 2022 Apr;59(4):673-81.
http://www.ncbi.nlm.nih.gov/pubmed/33402006?tool=bestpractice.com
[21]Mwanga HH, Baatjies R, Jeebhay MF. Occupational risk factors and exposure-response relationships for airway disease among health workers exposed to cleaning agents in tertiary hospitals. Occup Environ Med. 2023 Jul;80(7):361-71.
https://oem.bmj.com/content/80/7/361.long
http://www.ncbi.nlm.nih.gov/pubmed/37137692?tool=bestpractice.com
[22]Barber CM, Cullinan P, Feary J, et al. British Thoracic Society clinical statement on occupational asthma. Thorax. 2022 May;77(5):433-42.
https://thorax.bmj.com/content/77/5/433.long
http://www.ncbi.nlm.nih.gov/pubmed/35314486?tool=bestpractice.com
A AO induzida por agentes sensibilizantes (causada por estímulos imunológicos) é responsável por uma proporção significativamente maior de todos os casos de AO do que a AO induzida por irritantes (causada por estímulos não imunológicos). Mais de 300 causas de AO induzida por agentes sensibilizantes foram relatadas.[23]Baur X, Bakehe P. Allergens causing occupational asthma: an evidence-based evaluation of the literature. Int Arch Occup Environ Health. 2014 May;87(4):339-63.
http://rd.springer.com/article/10.1007/s00420-013-0866-9/fulltext.html
http://www.ncbi.nlm.nih.gov/pubmed/23595938?tool=bestpractice.com
[24]Cartier A. New causes of immunologic occupational asthma, 2012-2014. Curr Opin Allergy Clin Immunol. 2015 Apr;15(2):117-23.
http://www.ncbi.nlm.nih.gov/pubmed/25961386?tool=bestpractice.com
Em alguns estudos, cerca de 90% de toda AO é atribuída à AO induzida por agentes sensibilizantes.[25]Tarlo SM, Liss GM. Occupational asthma: an approach to diagnosis and management. CMAJ. 2003 Apr 1;168(7):867-71.
http://www.cmaj.ca/cgi/content/full/168/7/867
http://www.ncbi.nlm.nih.gov/pubmed/12668547?tool=bestpractice.com
Em 2014-2018, no Reino Unido, a incidência de AO induzida por irritantes foi estimada em 0.56 por milhão de empregados por ano.[26]Fishwick D, Carder M, Iskandar I, et al. Irritant asthma and work: cases from the UK SWORD reporting scheme from 1999 to 2018. Occup Environ Med. 2023 Oct;80(10):553-7.
https://oem.bmj.com/content/80/10/553.long
http://www.ncbi.nlm.nih.gov/pubmed/37770178?tool=bestpractice.com
Mundialmente, as causas mais comuns de AO são di-isocianatos e farinha.[27]Tarlo SM, Liss GM, Yeung KS. Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures. Occup Environ Med. 2002 Jan;59(1):58-62.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1740212
http://www.ncbi.nlm.nih.gov/pubmed/11836470?tool=bestpractice.com
[28]Le Moual N, Kennedy SM, Kauffmann F. Occupational exposures and asthma in 14,000 adults from the general population. Am J Epidemiol. 2004 Dec 1;160(11):1108-16.
http://aje.oxfordjournals.org/cgi/content/ful/160/11/1108
http://www.ncbi.nlm.nih.gov/pubmed/15561990?tool=bestpractice.com
[29]Vandenplas O, Godet J, Hurdubaea L, et al. Are high- and low-molecular-weight sensitizing agents associated with different clinical phenotypes of occupational asthma? Allergy. 2019 Feb;74(2):261-72.
http://www.ncbi.nlm.nih.gov/pubmed/29956349?tool=bestpractice.com
Na América do Norte, a exposição ao cedro vermelho ocidental é uma causa importante.[30]Malo JL, Ghezzo H, D'Aquino C, et al. Natural history of occupational asthma: relevance of type of agent and other factors in the rate of development of symptoms in affected subjects. J Allergy Clin Immunol. 1992 Dec;90(6 pt 1):937-44.
http://www.ncbi.nlm.nih.gov/pubmed/1460199?tool=bestpractice.com
Os relatórios indicam que a produção de maconha (cannabis) pode estar associada a sintomas do trato respiratório, incluindo AO.[31]Weaver VM, Hua JT, Fitzsimmons KM, et al. Fatal occupational asthma in cannabis production - Massachusetts, 2022. MMWR Morb Mortal Wkly Rep. 2023 Nov 17;72(46):1257-61.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684356
http://www.ncbi.nlm.nih.gov/pubmed/37971937?tool=bestpractice.com
[32]Decuyper II, Green BJ, Sussman GL, et al. Occupational allergies to cannabis. J Allergy Clin Immunol Pract. 2020 Nov-Dec;8(10):3331-8.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837257
http://www.ncbi.nlm.nih.gov/pubmed/33161961?tool=bestpractice.com
Muitos casos de asma induzida por irritantes estão relacionados a produtos químicos ácidos ou alcalinos corrosivos.[33]Lindström I, Lantto J, Karvala K, et al. Occupations and exposure events in acute and subacute irritant-induced asthma. Occup Environ Med. 2021 Nov;78(11):793-800.
https://oem.bmj.com/content/78/11/793.long
http://www.ncbi.nlm.nih.gov/pubmed/33790028?tool=bestpractice.com
Eventos agudos de inalação sintomática, como incêndio, mistura de produtos de limpeza e derramamentos de produtos químicos, estão associados ao risco excessivo de asma.[9]Kogevinas M, Zock JP, Jarvis D, et al. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet. 2007 Jul 28;370(9584):336-41.
http://www.ncbi.nlm.nih.gov/pubmed/17662882?tool=bestpractice.com