Em pacientes com meningiomas conhecidos, deve-se avaliar o uso de terapia hormonal. A associação entre o uso de hormônios exógenos e o risco de meningioma tem sido estudada, embora os dados continuem esparsos e inconclusivos.[37]Claus EB, Black PM, Bondy ML, et al. Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer. 2007 Aug 1;110(3):471-6.
http://onlinelibrary.wiley.com/doi/10.1002/cncr.22783/full
http://www.ncbi.nlm.nih.gov/pubmed/17580362?tool=bestpractice.com
[38]Korhonen K, Raitanen J, Isola J, et al. Exogenous sex hormone use and risk of meningioma: a population-based case-control study in Finland. Cancer Causes Control. 2010 Dec;21(12):2149-56.
http://www.ncbi.nlm.nih.gov/pubmed/20730482?tool=bestpractice.com
Recomendações consensuais foram publicadas sobre o manejo do meningioma e a terapia hormonal sexual.[44]Reuter G, Potorac I, de Herdt C, et al. Recommendations on the management of meningioma and sex hormone therapy: the results of a collaborative effort between neurosurgical, endocrine and gynecological societies. Brain Spine. 2025;5:104154.
https://www.sciencedirect.com/science/article/pii/S2772529424014103
http://www.ncbi.nlm.nih.gov/pubmed/39802864?tool=bestpractice.com
Há relatos de caso de degeneração maligna de meningiomas após radiação.[130]Lall RR, Lall RR, Smith TR, et al. Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery. J Clin Neurosci. 2014 Jul;21(7):1225-8.
http://www.ncbi.nlm.nih.gov/pubmed/24491582?tool=bestpractice.com
[131]Osipov V, Ho KC, Krouwer HG, et al. Post-radiation dedifferentiation of meningioma into osteosarcoma. BMC Cancer. 2002 Dec 3:2:34.
http://www.biomedcentral.com/1471-2407/2/34
http://www.ncbi.nlm.nih.gov/pubmed/12464160?tool=bestpractice.com
No entanto, a desdiferenciação não foi definitivamente ligada à radioterapia.[132]Rogers L, Barani I, Chamberlain M, et al. Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg. 2015 Jan;122(1):4-23.
http://www.ncbi.nlm.nih.gov/pubmed/25343186?tool=bestpractice.com