Acloridria

Os pacientes devem ser informados de que a redução da secreção de ácido pode prejudicar a absorção de alguns medicamentos (por exemplo, levotiroxina, atazanavir, cetoconazol, itraconazol, cefpodoxima, dipiridamol).[138]Lahner E, Annibale B, Delle Fave G. Systemic review: Helicobacter pylori infection and impaired drug absorption. Aliment Pharmacol Ther. 2009 Feb 15;29(4):379-86. http://www.ncbi.nlm.nih.gov/pubmed/19053985?tool=bestpractice.com [139]Lahner E, Annibale B, Delle Fave G. Systemic review: impaired drug absorption related to the co-administration of antisecretory therapy. Aliment Pharmacol Ther. 2009 Jun 15;29(12):1219-29. http://www.ncbi.nlm.nih.gov/pubmed/19302263?tool=bestpractice.com [140]Oosterhuis B, Jonkman JH, Andersson T, et al. Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose. Br J Clin Pharmac. 1991 Nov;32(5):569-72. http://www.ncbi.nlm.nih.gov/pubmed/1954072?tool=bestpractice.com [141]Soons PA, van den Berg G, Danhof M, et al. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects. Eur J Clin Pharmacol. 1992;42(3):319-24. http://www.ncbi.nlm.nih.gov/pubmed/1577051?tool=bestpractice.com [142]Checchi S, Montanaro A, Pasqui L, et al. L-thyroxine requirement in patients with autoimmune hypothyroidism and parietal cell antibodies. J Clin Endocrinol Metab. 2008 Feb;93(2):465-9. http://www.ncbi.nlm.nih.gov/pubmed/18042648?tool=bestpractice.com ​ Pode ser necessária uma dose maior para se atingir a eficácia.