Rastreamento de pessoas com HIV
O rastreamento de antígeno polissacarídeo criptocócico (CrAg) no sangue é recomendado para pessoas que vivem com HIV com contagens de CD4 <100 células/microlitro.[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Jun 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
[35]Chang CC, Harrison TS, Bicanic TA, et al. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis. 2024 Aug;24(8):e495-512. [Erratum in: Lancet Infect Dis. 2024 Aug;24(8):e485.]
https://www.idsociety.org/globalassets/idsa/practice-guidelines/diagnosis-and-management-of-crypto/global-guideline-for-the-diagnosis-and-management-of-cryptococcosis-an-initiative-of-the-ecmm-and-isham-in-cooperation-with-the-asm.pdf
http://www.ncbi.nlm.nih.gov/pubmed/38346436?tool=bestpractice.com
Pode-se também considerar o rastreamento de CrAg com um limiar de contagem de CD4 mais elevado <200 células/microlitro.[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. Oct 2024 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis
[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Jun 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
De acordo com a Organização Mundial da Saúde (OMS), quando o teste de CrAg de um paciente é positivo, a primeira consideração deve ser determinar se ele apresenta sinais/sintomas de meningite. Se houver suspeita de meningite, o paciente deve ser submetido a punção lombar para determinar se ele tem meningite criptocócica.[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Jun 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
Nos EUA, o rastreamento de CrAg sérico de rotina é recomendado para pessoas que atendam aos seguintes critérios:[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. Oct 2024 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis
Novo diagnóstico de HIV, e
Nenhum sinal clínico evidente de meningite, e
Contagem de CD4 ≤200 células/microlitro, particularmente naqueles com contagem de CD4 ≤50 células/microlitro.
As diretrizes dos EUA recomendam a punção lombar em todas as pessoas com HIV que tenham um teste sérico de CrAg positivo.[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. Oct 2024 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis