Estima-se que 3.5 bilhões de pessoas no mundo tenham ingestão inadequada de zinco.[17]Passarelli S, Free CM, Shepon A, et al. Global estimation of dietary micronutrient inadequacies: a modelling analysis. Lancet Glob Health. 2024 Oct;12(10):e1590-9.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11426101
http://www.ncbi.nlm.nih.gov/pubmed/39218000?tool=bestpractice.com
A deficiência de zinco nutricional é altamente predominante em regiões em desenvolvimento devido a uma combinação de ingestão inadequada de zinco e alto consumo de substâncias que limitam a absorção de zinco, como fitatos, oxalatos e, em alguns casos, argila. O consumo de argila ou "pica" é comum entre as crianças de algumas comunidades. A argila liga-se com eficiência ao zinco, causando uma redução drástica da biodisponibilidade. Crianças e idosos parecem apresentar o maior risco.[18]Oldewage-Theron WH, Samuel FO, Venter CS. Zinc deficiency among the elderly attending a care centre in Sharpeville, South Africa. J Hum Nutr Diet. 2008 Dec;21(6):566-74.
http://www.ncbi.nlm.nih.gov/pubmed/19017101?tool=bestpractice.com
[19]Fischer Walker C, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr. 2004;24:255-75.
http://www.ncbi.nlm.nih.gov/pubmed/15189121?tool=bestpractice.com
[20]Schneider JM, Fujii ML, Lamp CL, et al. The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency. J Am Diet Assoc. 2007 Nov;107(11):1924-9.
http://jandonline.org/article/S0002-8223(07)01621-5/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/17964312?tool=bestpractice.com
A prevalência da deficiência de zinco nos EUA e em outros países desenvolvidos é menos clara. Devido ao alto consumo de carnes e à fortificação de cereais, geralmente, a deficiência de zinco é considerada incomum em adolescentes e adultos saudáveis. Entretanto, altas taxas de deficiência de zinco foram documentadas em muitas subpopulações nos EUA, incluindo: bebês com dietas pobres em nutrientes; pessoas com doença gastrointestinal crônica, doença hepática, doença falciforme, doença renal, transtornos decorrentes do uso de bebidas alcoólicas, infecção por HIV, anorexia nervosa e idosos.[1]Krebs NF, Miller LV, Hambidge KM. Zinc deficiency in infants and children: a review of its complex and synergistic interactions. Paediatr Int Child Health. 2014 Nov;34(4):279-88.
http://www.ncbi.nlm.nih.gov/pubmed/25203844?tool=bestpractice.com
[2]Zupo R, Sila A, Castellana F, et al. Prevalence of zinc deficiency in inflammatory bowel disease: a systematic review and meta-analysis. Nutrients. 2022 Sep 29;14(19):4052.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9572015
http://www.ncbi.nlm.nih.gov/pubmed/36235709?tool=bestpractice.com
[3]Jivraj A, Hutchinson JM, Ching E, et al. Micronutrient deficiencies are frequent in adult patients with and without celiac disease on a gluten-free diet, regardless of duration and adherence to the diet. Nutrition. 2022 Nov-Dec;103-104:111809.
http://www.ncbi.nlm.nih.gov/pubmed/36096056?tool=bestpractice.com
[4]Katayama K, Kawaguchi T, Shiraishi K, et al. The prevalence and implication of zinc deficiency in patients with chronic liver disease. J Clin Med Res. 2018 May;10(5):437-4.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5862092
http://www.ncbi.nlm.nih.gov/pubmed/29581807?tool=bestpractice.com
[5]Baj J, Flieger W, Teresiński G, et al. Magnesium, calcium, potassium, sodium, phosphorus, selenium, zinc, and chromium levels in alcohol use disorder: a review. J Clin Med. 2020 Jun 18;9(6):1901.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7357092
http://www.ncbi.nlm.nih.gov/pubmed/32570709?tool=bestpractice.com
[6]Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr. 2002 Feb;75(2):181-2.
http://ajcn.nutrition.org/content/75/2/181.full
http://www.ncbi.nlm.nih.gov/pubmed/11815307?tool=bestpractice.com
[7]Perrone L, Gialanella G, Giordano V, et al. Impaired zinc metabolic status in children affected by idiopathic nephrotic syndrome. Eur J Pediatr. 1990 Mar;149(6):438-40.
http://www.ncbi.nlm.nih.gov/pubmed/2332016?tool=bestpractice.com
[8]Koch J, Neal EA, Schlott MJ, et al. Zinc levels and infections in hospitalized patients with AIDS. Nutrition. 1996 Jul-Aug;12(7-8):515-8.
http://www.ncbi.nlm.nih.gov/pubmed/8878145?tool=bestpractice.com
[9]Meunier N, O'Connor JM, Maiani G, et al. Importance of zinc in the elderly: the ZENITH study. Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S1-4.
https://www.nature.com/articles/1602286
http://www.ncbi.nlm.nih.gov/pubmed/16254574?tool=bestpractice.com
[10]Tumer N, Baskan S, Arcasoy A, et al. Hypozincemia in nephrotic syndrome. Clin Nephrol. 1991 Mar;35(3):135-7.
http://www.ncbi.nlm.nih.gov/pubmed/2032400?tool=bestpractice.com
[11]Stec J, Podracka L, Pavkovcekova O, et al. Zinc and copper metabolism in nephrotic syndrome. Nephron. 1990;56(2):186-7.
http://www.ncbi.nlm.nih.gov/pubmed/2243574?tool=bestpractice.com
[12]Lindberg L, Ostberg M, Isacson IM, et al. Feeding disorders related to nutrition. Acta Paediatr. 2006 Apr;95(4):425-9.
http://www.ncbi.nlm.nih.gov/pubmed/16720489?tool=bestpractice.com
[13]Castro J, Deulofeu R, Gila A, et al. Persistence of nutritional deficiencies after short-term weight recovery in adolescents with anorexia nervosa. Int J Eat Disord. 2004 Mar;35(2):169-78.
http://www.ncbi.nlm.nih.gov/pubmed/14994354?tool=bestpractice.com
Os Centros de Controle e Prevenção de Doenças (CDC) relatam que altas taxas de deficiência foram observadas em algumas populações de refugiados na Tailândia, incluindo aqueles originários de Mianmar (antiga Birmânia), bem como aqueles de origem étnica Karen (de Myanmar).[14]Centers for Disease Control and Prevention. Immigrant and refugee health: nutrition and growth. May 2025 [internet publication].
https://www.cdc.gov/immigrant-refugee-health/hcp/domestic-guidance/nutrition-and-growth.html
[21]Stuetz W, Carrara VI, McGready R, et al. Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp. Eur J Nutr. 2012 Jun;51(4):425-34.
https://link.springer.com/article/10.1007/s00394-011-0226-z
http://www.ncbi.nlm.nih.gov/pubmed/21786020?tool=bestpractice.com
[22]Faraj, Nancy. Nutritional status of under five year old Burmese refugee children in Thailand. ScholarSpace. 2005 May; 3953.
https://scholarspace.manoa.hawaii.edu/items/a8fa479e-40a3-44d7-bf65-873ac53c5187
A acrodermatite enteropática é rara, afetando menos que 1 em 500,000 pessoas ao redor do mundo.[23]Ackland ML, Michalczyk A. Zinc deficiency and its inherited disorders - a review. Genes Nutr. 2006 Mar;1(1):41-9.
http://www.ncbi.nlm.nih.gov/pubmed/18850219?tool=bestpractice.com