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Last reviewed: 24 Jul 2025
Last updated: 22 Aug 2025

Summary

Definition

History and exam

Key diagnostic factors

  • pain (anterior uveitis)
  • decreased vision
  • synechiae
  • flare
  • keratic precipitates

Other diagnostic factors

  • tearing
  • photophobia
  • floaters
  • eye redness without discharge
  • constricted or nonreactive pupil
  • decreased intraocular pressure
  • retinal exudates and edema, optic nerve edema
  • retinal vascular sheathing
  • macular edema
  • optic disk swelling
  • retinal hemorrhages
  • ciliary flush
  • corneal edema
  • cataract

Risk factors

  • inflammatory diseases of the joints, bowel, or skin
  • human leukocyte antigen (HLA)-B27 positive
  • ocular trauma
  • age 20-60 years

Diagnostic tests

1st tests to order

  • clinical diagnosis
  • slit-lamp biomicroscopy
  • tonometry
  • gonioscopy

Tests to consider

  • visual field testing
  • optical coherence tomography (OCT)
  • fluorescein angiography
  • CBC
  • erythrocyte sedimentation rate (ESR)
  • CRP
  • fluorescent treponemal antibody (FTA-ABS), Venereal Disease Research Laboratory (VDRL), and rapid plasma reagin (RPR)
  • serum ACE
  • antinuclear antibodies (ANAs)
  • HLA-B27
  • Lyme titer
  • purified protein derivative (PPD) skin test
  • cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA)
  • perinuclear antineutrophil cytoplasmic antibodies (p-ANCA)
  • anti-double-stranded DNA antibody (anti-dsDNA)
  • rheumatoid factor
  • anti-cyclic citrullinated peptide (anti-CCP) antibodies
  • Bartonella henselae titer
  • toxoplasma serologic titer
  • other HLA antigens
  • biochemistry screen
  • chest x-ray
  • real-time polymerase chain reaction (PCR) for ocular infectious disease
  • diagnostic vitrectomy biopsy

Treatment algorithm

Contributors

Authors

President

Connecticut Uveitis Foundation

Associate Clinical Professor

Yale University

New Haven

New England Retina Associates

Hamden

CT

Disclosures

JJH declares that he has no competing interests.

Uveitis and Retina Specialist

Medical Eye Center of New Hampshire

Manchester

NH

Disclosures

ME declares that he has no competing interests.

Dr John J. Huang and Dr Maxwell Elia would like to gratefully acknowledge Dr Richard Gale, Dr Zsolt Varga, Dr Victor L. Perez, and Dr Carlos A. Medina, the previous contributors to this topic.

Disclosures

RG, ZV, VLP, and CAM declare that they have no competing interests.

Peer reviewers

Assistant Professor

Ophthalmology

Mount Sinai Hospital

New York

NY

Disclosures

JA declares that she has no competing interests.

Director of Ophthalmology

Alfred Hospital

Melbourne

Australia

Disclosures

AJH has been reimbursed by Novartis, the manufacturer of Lucentis, for lecture fees. AJH's employer, the Alfred Hospital, has received research funding from Novartis, the manufacturer of Lucentis, and from Bayer, the manufacturer of Eylea.

Chairman

Department of Ophthalmology

The University of Texas Health Science Center at San Antonio

San Antonio

TX

Disclosures

DAJ declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Deschenes J, Murray PI, Rao NA, et al; International Uveitis Study Group. International Uveitis Study Group (IUSG): clinical classification of uveitis. Ocul Immunol Inflamm. 2008 Jan-Feb;16(1):1-2. Abstract

Jabs DA, Nussenblatt RD, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data: results of the First International Workshop. Am J Ophthalmol. 2005 Sep;140(3):509-16. Abstract

Foster CS, Kothari S, Anesi SD, et al. The Ocular Immunology and Uveitis Foundation preferred practice patterns of uveitis management. Surv Ophthalmol. 2016 Jan-Feb;61(1):1-17. Abstract

Dick AD, Rosenbaum JT, Al-Dhibi HA, et al. Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative. Ophthalmology. 2018 May;125(5):757-73.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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