Vitamin D deficiency

Calcifediol

Calcifediol, a prohormone of the active form of vitamin D3, is available in some regions (either on prescription or as an over-the-counter supplement) to treat vitamin D deficiency. When taken orally, calcifediol rapidly increases circulating concentrations of 25-hydroxyvitamin D3 in vitamin D-deficient adults. Calcifediol has been demonstrated to be as effective in raising serum concentrations of 25-hydroxyvitamin D in adults with obesity compared to normal weight adults and patients with malabsorption syndromes.[139]Halsted CH. Dietary supplements and the american journal of clinical nutrition(1). Am J Clin Nutr. 2000 Feb;71(2):399-400. http://www.ncbi.nlm.nih.gov/pubmed/10648249?tool=bestpractice.com [140]Biondi P, Pepe J, Biamonte F, et al. Oral calcidiol is a good form of vitamin D supplementation. Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):207-8. https://pmc.ncbi.nlm.nih.gov/articles/PMC5726211 http://www.ncbi.nlm.nih.gov/pubmed/29263735?tool=bestpractice.com ​​ High-dose calcifediol is also used to treat secondary hyperparathyroidism in patients with chronic kidney disease. Calcifediol is not currently approved in the US for the treatment of vitamin D deficiency, but may be licensed in other countries for this indication.