Complications

Complication
Timeframe
Likelihood
short term
high

Causative organisms include Staphylococcus aureus, beta-haemolytic streptococci, gram-negative rods, and anaerobes.

short term
high

Occurs due to a reduction in compartment size produced by the freezing injury.

Can be very difficult to diagnose as patients with frostbite already have many of the symptoms. A high index of suspicion should be maintained in all patients, especially if there is any worsening in condition.

Requires surgical treatment with fasciotomy.

short term
high

Mummification (dry gangrene) is seen in fourth-degree injuries. Infection of necrotic tissue can lead to wet gangrene, which is an indication for early amputation.

long term
high

Related to the underlying scars and mechanical problems usually resulting from tissue injury and amputations.[1][2][9] In children, damage to the underlying bone can be more severe, with diminished growth of the affected bone and early arthritis.[14]

long term
high

A common complaint post-frostbite and often unresponsive to conventional analgesia. Amitriptyline or gabapentin may be of benefit, but these patients often require referral to a chronic pain specialist.[14]

Complex regional pain syndrome

long term
medium

Performed once the viability of the tissue is definitively assessed, usually 1 to 3 months after the initial injury.[4]​​

Risk factors for amputation include third- or fourth-degree injury, late presentation, lower extremity involvement, and infection of the injured tissue.

If the patient develops wet gangrene or sepsis, early amputation is required.

long term
low

Areas of chronic ulceration due to poor tissue quality are prone to malignant squamous transformation similar to Marjolin's ulcers seen in old burn scars.[14][16]

Squamous cell carcinoma of the skin

variable
high

Previously frostbitten tissue has increased cold sensitivity and susceptibility to the tissue changes associated with frostbite.

Recurrent injury occurs more easily than the original injury and is usually more severe.

Patients should keep the injury well protected from cold; wear warm, non-restrictive clothing; and avoid extreme conditions.

variable
medium

Antibiotics and tetanus prophylaxis are often administered in the emergency department. Despite these measures, necrotic tissue is susceptible to infection, which can lead to systemic infection, sepsis, and shock. Under these conditions, early amputation can be life-saving.[1][10][12][37]

variable
low

Frostbite is considered to be a high-risk wound.

The administration of tetanus prophylaxis should prevent this complication in most cases.

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