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Last reviewed: 21 Apr 2025
Last updated: 23 Nov 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors

Other diagnostic factors

  • pain
  • pressure (muscle tightness)
  • paraesthesia
  • paralysis

Risk factors

  • trauma
  • bleeding disorder
  • compression support
  • thermal injury
  • intense muscular activity
  • extravasation of intravenous infusion
  • venous obstruction

Diagnostic investigations

1st investigations to order

  • compartment pressure measurement

Investigations to consider

  • serum creatine kinase
  • urine myoglobin
  • troponin

Treatment algorithm

Contributors

Authors

Dr Arvind von Keudell, MD, MPH

Orthopaedic Trauma Surgeon

Associate Professor

Brigham and Women's Hospital, Harvard Medical School

Bispebjerg Hospital, University of Copenhagen

Copenhagen

Denmark

Disclosures

AK declares that he has no competing interests.

Acknowledgements

Dr Arvind von Keudell would like to gratefully acknowledge Dr Miren A. Schinco and Dr Victor J. Hassid, the previous contributors to this topic.

Disclosures

MAS and VJH declare that they have no competing interests.

Peer reviewers

Jennifer Cone, MD, MHS, FACS

Assistant Professor of Surgery, Section of Trauma and Acute Care Surgery

Associate Program Director, General Surgery Residency Program

Co-Director, Military General Surgery Residency Program

Department of Surgery

The University of Chicago Medicine and Biological Sciences

Chicago

IL

Disclosures

JC declares that she has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

American Academy of Orthopaedic Surgeons, Major Extremity Trauma and Rehabilitation Consortium. Diagnosis and management of acute compartment syndrome. Sep 2019 [internet publication].Full text

British Orthopaedic Association. Diagnosis and management of compartment syndrome of the limbs​. 2015 [internet publication].Full text

Reference articles

A full list of sources referenced in this topic is available here.

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