There are no specific studies on the prevention of FTD. However, a number of risk factors in early and mid life have been associated with increased risk of dementia in later life. These include less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, infrequent social contact, excessive alcohol consumption, head injury, and air pollution.[54]Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-46.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30367-6/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/32738937?tool=bestpractice.com
Some of these risk factors are modifiable, and preventive strategies have been recommended.[54]Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-46.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30367-6/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/32738937?tool=bestpractice.com
Convincing evidence for effectiveness of interventions is not yet available, but trials are ongoing.[55]Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255-63.
http://www.ncbi.nlm.nih.gov/pubmed/25771249?tool=bestpractice.com
[56]Vellas B, Carrie I, Gillette-Guyonnet S, et al. MAPT study: a multidomain approach for preventing Alzheimer's disease: design and baseline data. J Prev Alzheimers Dis. 2014 Jun;1(1):13-22.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652787
http://www.ncbi.nlm.nih.gov/pubmed/26594639?tool=bestpractice.com
[57]Moll van Charante EP, Richard E, Eurelings LS, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016 Aug 20;388(10046):797-805.
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