Prognosis

Eosinophilic oesophagitis (EoO) is a chronic disease.[164] However, the prognosis is good. The majority of patients have a good response to either pharmacological or dietary elimination therapy. If strictures or oesophageal narrowing develop, these can be effectively treated with oesophageal dilation. 

Approximately one third of patients may be refractory to standard treatments and these patients can be very difficult to treat; often they are referred to clinical trials.[27]​ Symptoms usually recur when treatment is stopped.[3]​ Patients who remain symptomatic despite achieving histological and endoscopic remission should be considered for further evaluation for potential oesophageal motility disorders.​[85][172][173]

Natural history

The natural history of EoO suggests that, in some patients, chronic eosinophilic inflammation can lead to fibrostenotic remodelling.[3]​[4][5][6][34]​​[174]​​[175]​​​ Data show that the longer symptoms are present before diagnosis and treatment the more common it is to have oesophageal strictures and signs of remodelling.

To date, there has been no association of EoO with oesophageal cancer, and no cases of EoO have devolved to a more diffuse eosinophilic gastroenteritis or to hypereosinophilic syndrome.

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