Deposição de bilirrubina nos gânglios da base do neonato. Evitada com o monitoramento rigoroso dos níveis de bilirrubina e a instituição adequada de fototerapia/exsanguineotransfusão.
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Alguns estudos encontraram aumento da incidência ou início precoce de catarata em pessoas com deficiência de G6PD.[11]Luzzatto L, Vincenzo P: Glucose-6-phosphate dehydrogenase deficiency. In: Orkin SH et al, eds: Nathan and Oski's Hematology and oncology of infancy and childhood. Philadelphia, PA: Saunders; 2015:609-29.[12]Beutler E. G6PD deficiency. Blood. 1994 Dec 1;84(11):3613-36.
https://ashpublications.org/blood/article/84/11/3613/118679/G6PD-deficiency
http://www.ncbi.nlm.nih.gov/pubmed/7949118?tool=bestpractice.com
[21]Luzzatto L, Mehta AB, Vulliamy T. Glucose 6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, eds. The metabolic and molecular bases of inherited disease, 8th ed. New York, NY: McGraw Hill; 2001:4517-53.[36]Wan GH, Lin KK, Tsai SC, et al. Decreased glucose-6-phosphate dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. Ophthalmic Epidemiol. 2006 Apr;13(2):109-14.
http://www.ncbi.nlm.nih.gov/pubmed/16581614?tool=bestpractice.com
Dados in vitro, observações em neonatos e em pacientes com trauma e estudos em animais mostram possível suscetibilidade elevada à infecção.[46]Abu-Osba YK, Mallouh AA, Hann RW. Incidence and causes of sepsis in glucose-6-phosphate dehydrogenase deficient newborn infants. J Pediatr. 1989 May;114(5):748-52.
http://www.ncbi.nlm.nih.gov/pubmed/2715888?tool=bestpractice.com
[47]Abraham E. Glucose-6-phosphate dehydrogenase and sepsis:the jury is still out. Crit Care Med. 2007 Feb;35(2):655-6.
http://www.ncbi.nlm.nih.gov/pubmed/17251719?tool=bestpractice.com
Isso pode ser explicado pela resposta alterada de citocinas e função prejudicada de neutrófilos em pessoas com deficiência de G6PD.[11]Luzzatto L, Vincenzo P: Glucose-6-phosphate dehydrogenase deficiency. In: Orkin SH et al, eds: Nathan and Oski's Hematology and oncology of infancy and childhood. Philadelphia, PA: Saunders; 2015:609-29.[21]Luzzatto L, Mehta AB, Vulliamy T. Glucose 6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, eds. The metabolic and molecular bases of inherited disease, 8th ed. New York, NY: McGraw Hill; 2001:4517-53.