References

Key articles

European Association of Urology. Non-muscle-invasive bladder cancer (TaT1 and CIS). 2025 [internet publication].Full text

European Association of Urology. Muscle-invasive and metastatic bladder cancer. 2025 [internet publication].Full text

American Urological Association. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO joint guideline. 2024 [internet publication].Full text

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: bladder cancer [internet publication].Full text

American Urological Association. Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline. Apr 2024 [internet publication].Full text

Reference articles

1. van Hoogstraten LMC, Vrieling A, van der Heijden AG, et al. Global trends in the epidemiology of bladder cancer: challenges for public health and clinical practice. Nat Rev Clin Oncol. 2023 May;20(5):287-304. Abstract

2. Colombel M, Soloway M, Akazac H, et al. Epidemiology, staging, grading, and risk stratification of bladder cancer. Eur Urol Suppl. 2008 Oct;7(10):618-26.Full text

3. Brierley JD, Gospodarowicz MK, Wittekind C, eds. Union for International Cancer Control (UICC). TNM classification of malignant tumors. 9th ed. Chichester: Wiley-Blackwell; 2025.

4. Amin MB, Edge S, Green F, et al. AJCC cancer staging manual. 8th ed. Cham, Switzerland: Springer International; 2017.

5. ​WHO Classification of Tumours Editorial Board. WHO classification of tumours of the urinary system and male genital organs. 8th ed. France: Lyon; 2022. Full text

6. Mostofi FK, Sobin LH, Torloni H, et al. Histological typing of urinary bladder tumours. In: International classification of tumors. Number 10. Geneva, Switzerland: World Health Organization; 1973.Full text

7. Sauter G, Algaba F, Amin M, et al. Tumours of the urinary system: non-invasive urothelial neoplasias. In: Eble JN, Sauter G, Epstein JI, Sesterhenn I, eds. WHO classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004.

8. Paner GP, Kamat A, Netto GJ, et al. International Society of Urological Pathology (ISUP) consensus conference on current issues in bladder cancer. Working group 2: grading of mixed grade, invasive urothelial carcinomaincluding histologic subtypes and divergent differentiations, and non-urothelial carcinomas. Am J Surg Pathol. 2023 Jun 29 [Epub ahead of print]. Abstract

9. Beijert IJ, Cheng L, Liedberg F, et al. International opinions on grading of urothelial carcinoma: a survey among European Association of Urology and International Society of urological pathology members. Eur Urol Open Sci. 2023 Jun;52:154-65.Full text  Abstract

10. Woldu SL, Bagrodia A, Lotan Y. Guideline of guidelines: non-muscle-invasive bladder cancer. BJU Int. 2017 Mar;119(3):371-80. Abstract

11. Jubber I, Ong S, Bukavina L, et al. Epidemiology of bladder cancer in 2023: a systematic review of risk factors. Eur Urol. 2023 Aug;84(2):176-90.Full text  Abstract

12. Cohn JA, Vekhter B, Lyttle C, et al. Sex disparities in diagnosis of bladder cancer after initial presentation with hematuria: a nationwide claims-based investigation. Cancer. 2014 Feb 15;120(4):555-61.Full text  Abstract

13. Mancini M, Righetto M, Baggio G. Spotlight on gender-specific disparities in bladder cancer. Urologia. 2020 Aug;87(3):103-14. Abstract

14. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-63.Full text  Abstract

15. National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Program. Cancer stat facts: bladder cancer. 2025 [internet publication].Full text

16. Scosyrev E, Noyes K, Feng C, et al. Sex and racial differences in bladder cancer presentation and mortality in the US. Cancer. 2009 Jan 1;115(1):68-74.Full text  Abstract

17. Washington SL 3rd, Gregorich SE, Meng MV, et al. Race modifies survival benefit of guideline-based treatment: Implications for reducing disparities in muscle invasive bladder cancer. Cancer Med. 2020 Nov;9(22):8310-8317.Full text  Abstract

18. Richters A, Aben KKH, Kiemeney LALM. The global burden of urinary bladder cancer: an update. World J Urol. 2020 Aug;38(8):1895-904.Full text  Abstract

19. Antoni S, Ferlay J, Soerjomataram I, et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017 Jan;71(1):96-108. Abstract

20. Cumberbatch MG, Rota M, Catto JW, et al. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol. 2016 Sep;70(3):458-66. Abstract

21. European Association of Urology. Non-muscle-invasive bladder cancer (TaT1 and CIS). 2025 [internet publication].Full text

22. Cumberbatch MG, Cox A, Teare D, et al. Contemporary occupational carcinogen exposure and bladder cancer: a systematic review and meta-analysis. JAMA Oncol. 2015 Dec;1(9):1282-90.Full text  Abstract

23. World Health Organization. ​International Agency for Research on Cancer. List of classifications by cancer sites with sufficient or limited evidence in humans. IARC monographs volumes 1-134. 2023 [internet publication].Full text

24. Di Giovanni P, Di Martino G, Scampoli P, et al. Arsenic exposure and risk of urothelial cancer: systematic review and meta-analysis. Int J Environ Res Public Health. 2020 Apr 29;17(9):3105.Full text  Abstract

25. Wang M, Yang Y, Liao Z. Diabetes and cancer: epidemiological and biological links. World J Diabetes. 2020 Jun 15;11(6):227-38.Full text  Abstract

26. Xu Y, Huo R, Chen X, et al. Diabetes mellitus and the risk of bladder cancer: a PRISMA-compliant meta-analysis of cohort studies. Medicine (Baltimore). 2017 Nov;96(46):e8588.Full text  Abstract

27. Tang H, Shi W, Fu S, et al. Pioglitazone and bladder cancer risk: a systematic review and meta-analysis. Cancer Med. 2018 Apr;7(4):1070-80.Full text  Abstract

28. Baddam S, Banka AV, Divity S, et al. Association between pioglitazone use and bladder cancer: a systematic review. Bladder (San Franc). 2024;11(4):e21200023.Full text  Abstract

29. Tuccori M, Filion KB, Yin H, et al. Pioglitazone use and risk of bladder cancer: population based cohort study. BMJ. 2016 Mar 30;352:i1541.Full text  Abstract

30. Teleka S, Häggström C, Nagel G, et al. Risk of bladder cancer by disease severity in relation to metabolic factors and smoking: a prospective pooled cohort study of 800,000 men and women. Int J Cancer. 2018 Dec 15;143(12):3071-82. Abstract

31. Alanee S, Alvarado-Cabrero I, Murugan P, et al. Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder. World J Urol. 2019 Jan;37(1):107-14. Abstract

32. Huang X, Pan T, Yan L, et al. The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer. Genes Dis. 2021 Nov;8(6):781-97.Full text  Abstract

33. Mossanen M, Nassar AH, Stokes SM, et al. Incidence of germline variants in familial bladder cancer and among patients with cancer predisposition syndromes. Clin Genitourin Cancer. 2022 Dec;20(6):568-74. Abstract

34. Carlo MI, Ravichandran V, Srinavasan P, et al. Cancer susceptibility mutations in patients with urothelial malignancies. J Clin Oncol. 2020 Feb 10;38(5):406-14.Full text  Abstract

35. Pemov A, Wegman-Ostrosky T, Kim J, et al. Identification of genetic risk factors for familial urinary bladder cancer: an exome sequencing study. JCO Precis Oncol. 2021;5:PO.21.00115.Full text  Abstract

36. Rozanski TA, Grossman HB. Recent developments in the pathophysiology of bladder cancer. Am J Radiol. 1994 Oct;163(4):789-92.Full text  Abstract

37. Lawson ARJ, Abascal F, Coorens THH, et al. Extensive heterogeneity in somatic mutation and selection in the human bladder. Science. 2020 Oct 2;370(6512):75-82.Full text  Abstract

38. Acar Ö, Özkurt E, Demir G, et al. Determining the origin of synchronous multifocal bladder cancer by exome sequencing. BMC Cancer. 2015 Nov 9;15:871.Full text  Abstract

39. Habuchi T. Origin of multifocal carcinomas of the bladder and upper urinary tract: molecular analysis and clinical implications. Int J Urol. 2005 Aug;12(8):709-16.Full text  Abstract

40. Pace KJC, Kwong JCC, Randhawa H, et al. Risk of metachronous upper tract urothelial carcinoma following non-muscle-invasive bladder cancer. BJU Int. 19 Nov 2025 [Epub ahead of print].Full text  Abstract

41. Sidranski D, Frost P, Von Eschenback A, et al. Clonal origin of bladder cancer. N Engl J Med. 1992 Mar 12;326(11):737-40. Abstract

42. Lopez-Beltran A, Cimadamore A, Montironi R, et al. Molecular pathology of urothelial carcinoma. Hum Pathol. 2021 Jul;113:67-83. Abstract

43. Lopez-Beltran A, Cookson MS, Guercio BJ, et al. Advances in diagnosis and treatment of bladder cancer. BMJ. 2024 Feb 12;384:e076743.Full text  Abstract

44. Zhao X, Wang Y, Liang C. Cigarette smoking and risk of bladder cancer: a dose-response meta-analysis. Int Urol Nephrol. 2022 Jun;54(6):1169-85. Abstract

45. Freedman ND, Silverman DT, Hollenbeck AR, et al. Association between smoking and risk of bladder cancer among men and women. JAMA. 2011 Aug 17;306(7):737-45.Full text  Abstract

46. Fernández MI, Brausi M, Clark PE, et al. Epidemiology, prevention, screening, diagnosis, and evaluation: update of the ICUD-SIU joint consultation on bladder cancer. World J Urol. 2019 Jan;37(1):3-13. Abstract

47. Kumar R, Matulewicz R, Mari A, et al. Impact of smoking on urologic cancers: a snapshot of current evidence. World J Urol. 2023 Jun;41(6):1473-9.Full text  Abstract

48. Cumberbatch MGK, Noon AP. Epidemiology, aetiology and screening of bladder cancer. Transl Androl Urol. 2019 Feb;8(1):5-11.Full text  Abstract

49. Matsukawa A, Yanagisawa T, Miszczyk M, et al. Incidence and outcomes of secondary bladder cancer following radiation therapy for prostate cancer: a systematic review and meta-analysis. Eur Urol Focus. 2025 May;11(3):471-81.Full text  Abstract

50. European Association of Urology. Muscle-invasive and metastatic bladder cancer. 2025 [internet publication].Full text

51. Jahreiß MC, Heemsbergen WD, Aben KKH, et al. Risk factors for secondary bladder cancer following prostate cancer radiotherapy. Transl Androl Urol. 2024 Jul 31;13(7):1288-96.Full text  Abstract

52. American Urological Association. Microhematuria: AUA/SUFU guideline (2025). 2025 [internet publication].Full text

53. Yohana C, Bakuza JS, Kinung'hi SM, et al. The trend of schistosomiasis related bladder cancer in the lake zone, Tanzania: a retrospective review over 10 years period. Infect Agent Cancer. 2023 Feb 19;18(1):10.Full text  Abstract

54. Andrade G, Bertsch DJ, Gazzinelli A, et al. Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2017 Feb;11(2):e0005372.Full text  Abstract

55. Dobruch J, Daneshmand S, Fisch M, et al. Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes. Eur Urol. 2016 Feb;69(2):300-10. Abstract

56. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: genetic/familial high-risk assessment: colorectal, endometrial, and gastric [internet publication].Full text

57. Cogliano VJ, Baan R, Straif K, et al. Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011 Dec 21;103(24):1827-39.Full text  Abstract

58. Peterson LM, Reed HS. Hematuria. Prim Care. 2019 Jun;46(2):265-73.Full text  Abstract

59. Jubber I, Shariat SF, Conroy S, et al. Non-visible haematuria for the detection of bladder, upper tract, and kidney cancer: an updated systematic review and meta-analysis. Eur Urol. 2020 May;77(5):583-98. Abstract

60. American Urological Association. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO joint guideline. 2024 [internet publication].Full text

61. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: bladder cancer [internet publication].Full text

62. Ingelfinger JR. Hematuria in adults. N Engl J Med. 2021 Jul 8;385(2):153-63. Abstract

63. National Institute for Health and Care Excellence​. Suspected cancer: recognition and referral. May 2025 [internet publication].Full text

64. O'Connor E, McVey A, Demkiw S, et al. Assessment and management of haematuria in the general practice setting. Aust J Gen Pract. 2021 Jul;50(7):467-71.Full text  Abstract

65. American College of Radiology. ACR appropriateness criteria: hematuria. 2019 [internet publication].Full text

66. Schmidt-Hansen M, Berendse S, Hamilton W. The association between symptoms and bladder or renal tract cancer in primary care: a systematic review. Br J Gen Pract. 2015 Nov;65(640):e769-75.Full text  Abstract

67. Shephard EA, Stapley S, Neal RD, et al. Clinical features of bladder cancer in primary care. Br J Gen Pract. 2012 Sep;62(602):e598-604.Full text  Abstract

68. Zheng C, Lv Y, Zhong Q, et al. Narrow band imaging diagnosis of bladder cancer: systematic review and meta-analysis. BJU Int. 2012 Dec;110(11 Pt B):E680-7.Full text  Abstract

69. Burger M, Grossman HB, Droller M, et al. Photodynamic diagnosis of non-muscle-invasive bladder cancer with hexaminolevulinate cystoscopy: a meta-analysis of detection and recurrence based on raw data. Eur Urol. 2013 Nov;64(5):846-54.Full text  Abstract

70. Maisch P, Koziarz A, Vajgrt J, et al. Blue versus white light for transurethral resection of non-muscle invasive bladder cancer. Cochrane Database Syst Rev. 2021 Dec 1;12(12):CD013776.Full text  Abstract

71. Ontario Health (Quality). Enhanced visualization methods for first transurethral resection of bladder tumour in suspected non-muscle-invasive bladder cancer: a health technology assessmen. Ont Health Technol Assess Ser. 2021;21(12):1-123.Full text  Abstract

72. Lai LY, Tafuri SM, Ginier EC, et al. Narrow band imaging versus white light cystoscopy alone for transurethral resection of non-muscle invasive bladder cancer. Cochrane Database Syst Rev. 2022 Apr 8;4(4):CD014887.Full text  Abstract

73. Gravestock P, Coulthard N, Veeratterapillay R, et al. Systematic review and meta-analysis of narrow band imaging for non-muscle-invasive bladder cancer. Int J Urol. 2021 Dec;28(12):1212-7.Full text  Abstract

74. Sari Motlagh R, Mori K, Laukhtina E, et al. Impact of enhanced optical techniques at time of transurethral resection of bladder tumour, with or without single immediate intravesical chemotherapy, on recurrence rate of non-muscle-invasive bladder cancer: a systematic review and network meta-analysis of randomized trials. BJU Int. 2021 Sep;128(3):280-9.Full text  Abstract

75. American College of Radiology. ACR appropriateness criteria: pretreatment staging of urothelial cancer. 2024 [internet publication].Full text

76. Del Giudice F, Pecoraro M, Vargas HA, et al. Systematic review and meta-analysis of vesical imaging-reporting and data system (VI-RADS) inter-observer reliability: an added value for muscle invasive bladder Cancer Detection. Cancers (Basel). 2020 Oct 15;12(10):2994.Full text  Abstract

77. Del Giudice F, Barchetti G, De Berardinis E, et al. Prospective assessment of vesical imaging reporting and data system (VI-RADS) and its clinical impact on the management of high-risk non-muscle-invasive bladder cancer patients candidate for repeated transurethral resection. Eur Urol. 2020 Jan;77(1):101-9. Abstract

78. Panebianco V, Briganti A, Boellaard TN, et al. Clinical application of bladder MRI and the Vesical Imaging-Reporting and Data System. Nat Rev Urol. 2024 Apr;21(4):243-251. Abstract

79. Lu YY, Chen JH, Liang JA, et al. Clinical value of FDG PET or PET/CT in urinary bladder cancer: a systemic review and meta-analysis. Eur J Radiol. 2012 Sep;81(9):2411-6.Full text  Abstract

80. Crozier J, Papa N, Perera M, et al. Comparative sensitivity and specificity of imaging modalities in staging bladder cancer prior to radical cystectomy: a systematic review and meta-analysis. World J Urol. 2019 Apr;37(4):667-90. Abstract

81. Tan WS, Sarpong R, Khetrapal P, et al. Does urinary cytology have a role in haematuria investigations? BJU Int. 2019 Jan;123(1):74-81.Full text  Abstract

82. Maas M, Todenhöfer T, Black PC. Urine biomarkers in bladder cancer - current status and future perspectives. Nat Rev Urol. 2023 Oct;20(10):597-614. Abstract

83. Pastorello RG, Barkan GA, Saieg M. Experience on the use of The Paris System for Reporting Urinary Cytopathology: review of the published literature. J Am Soc Cytopathol. 2021 Jan-Feb;10(1):79-87.Full text  Abstract

84. Soorojebally Y, Neuzillet Y, Roumiguié M, et al. Urinary biomarkers for bladder cancer diagnosis and NMIBC follow-up: a systematic review. World J Urol. 2023 Feb;41(2):345-59. Abstract

85. Budman LI, Kassouf W, Steinberg JR. Biomarkers for detection and surveillance of bladder cancer. Can Urol Assoc J. 2008 Jun;2(3):212-21.Full text  Abstract

86. Ramirez D, Gupta A, Canter D, et al. Microscopic haematuria at time of diagnosis is associated with lower disease stage in patients with newly diagnosed bladder cancer. BJU Int. 2016 May;117(5):783-6.Full text  Abstract

87. Rouprêt M, Seisen T, Birtle AJ, et al. European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2023 update. Eur Urol. 2023 Jul;84(1):49-64.Full text  Abstract

88. Coleman JA, Clark PE, Bixler BR, et al. Diagnosis and management of non-metastatic upper tract urothelial carcinoma: AUA/SUO guideline. J Urol. 2023 Jun;209(6):1071-81.Full text  Abstract

89. Ritch CR, Velasquez MC, Kwon D, et al. Use and validation of the AUA/SUO risk grouping for nonmuscle invasive bladder cancer in a contemporary cohort. J Urol. 2020 Mar;203(3):505-11. Abstract

90. Sylvester RJ, van der Meijden AP, Oosterlinck W, et al. Predicting recurrence and progression in individual patients with stage TaT1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol. 2006 Mar;49(3):466-5. Abstract

91. Fernandez-Gomez J, Madero R, Solsona E, et al. The EORTC tables overestimate the risk of recurrence and progression in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-Guérin: external validation of the EORTC risk tables. Eur Urol. 2011 Sep;60(3):423-30. Abstract

92. Messing EM, Madeb R, Young T, et al. Long-term outcome of hematuria home screening for bladder cancer in men. Cancer. 2006 Nov 1;107(9):2173-9.Full text  Abstract

93. Han MA, Maisch P, Jung JH, et al. Intravesical gemcitabine for non-muscle invasive bladder cancer. Cochrane Database Syst Rev. 2021 Jun 14;6(6):CD009294.Full text  Abstract

94. Lenis AT, Lec PM, Chamie K, et al. Bladder cancer: a review. JAMA. 2020 Nov 17;324(19):1980-91. Abstract

95. Chou R, Selph S, Buckley DI, et al. Intravesical therapy for the treatment of nonmuscle invasive bladder cancer: a systematic review and meta-analysis. J Urol. 2017 May;197(5):1189-99. Abstract

96. Kaufman DS, Shipley WU, Feldman AS. Bladder cancer. Lancet. 2009 Jul 18;374(9685):239-49. Abstract

97. Oddens J, Brausi M, Sylvester R, et al. Final results of an EORTC-GU cancers group randomized study of maintenance bacillus Calmette-Guérin in intermediate- and high-risk Ta, T1 papillary carcinoma of the urinary bladder: one-third dose versus full dose and 1 year versus 3 years of maintenance. Eur Urol. 2013 Mar;63(3):462-72. Abstract

98. Lamm DL, Blumenstein BA, Crissman JD, et al. Maintenance bacillus Calmette-Guérin immunotherapy for recurrent TA, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. J Urol. 2000 Apr;163(4):1124-9. Abstract

99. Steinberg RL, Thomas LJ, Brooks N, et al. Multi-institution evaluation of sequential gemcitabine and docetaxel as rescue therapy for nonmuscle invasive bladder cancer. J Urol. 2020 May;203(5):902-9. Abstract

100. Barlow LJ, McKiernan JM, Benson MC. Long-term survival outcomes with intravesical docetaxel for recurrent nonmuscle invasive bladder cancer after previous bacillus Calmette-Guérin therapy. J Urol. 2013 Mar;189(3):834-9. Abstract

101. Sylvester RJ, Oosterlinck W, Holmang S, et al. Systematic review and individual patient data meta-analysis of randomized trials comparing a single immediate instillation of chemotherapy after transurethral resection with transurethral resection alone in patients with stage pTa-pT1 urothelial carcinoma of the bladder: which patients benefit from the instillation? Eur Urol. 2016 Feb;69(2):231-44. Abstract

102. Bosschieter J, Nieuwenhuijzen JA, Vis AN, et al. An immediate, single intravesical instillation of mitomycin C is of benefit in patients with non-muscle-invasive bladder cancer irrespective of prognostic risk groups. Urol Oncol. 2018 Sep;36(9):400.e7-400.e14. Abstract

103. Brausi M, Collette L, Kurth K, et al. Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: a combined analysis of seven EORTC studies. Eur Urol. 2002 May;41(5):523-31. Abstract

104. Holmang S, Johansson SL. Stage Ta-T1 bladder cancer: the relationship between findings at first followup cystoscopy and subsequent recurrence and progression. J Urol. 2002 Apr;167(4):1634-7. Abstract

105. Herr HW, Donat SM, Dalbagni G. Can restaging transurethral resection of T1 bladder cancer select patients for immediate cystectomy? J Urol. 2007 Jan;177(1):75-9. Abstract

106. Jakse G, Algaba F, Malmström PU, et al. A second-look TUR in T1 transitional cell carcinoma: why? Eur Urol. 2004 May;45(5):539-46. Abstract

107. Divrik T, Yildirim U, Eroğlu AS, et al. Is a second transurethral resection necessary for newly diagnosed pT1 bladder cancer? J Urol. 2006 Apr;175(4):1258-61. Abstract

108. Maibom SL, Joensen UN, Poulsen AM, et al. Short-term morbidity and mortality following radical cystectomy: a systematic review. BMJ Open. 2021 Apr 14;11(4):e043266.Full text  Abstract

109. Daneshmand S, Van der Heijden MS, Jacob JM, et al. TAR-200 for Bacillus Calmette-Guérin-unresponsive high-risk non-muscle-invasive bladder cancer: results from the phase IIb SunRISe-1 study. J Clin Oncol. 2025 Nov 20;43(33):3578-88.Full text  Abstract

110. Balar AV, Kamat AM, Kulkarni GS, et al. Pembrolizumab monotherapy for the treatment of high-risk non-muscle-invasive bladder cancer unresponsive to BCG (KEYNOTE-057): an open-label, single-arm, multicentre, phase 2 study. Lancet Oncol. 2021 Jul;22(7):919-930. Abstract

111. Boorjian SA, Alemozaffar M, Konety BR, et al. Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial. Lancet Oncol. 2021 Jan;22(1):107-117. Abstract

112. Chamie K, Chang SS, Kramolowsky E, et al. IL-15 superagonist NAI in BCG-unresponsive non-muscle-invasive bladder cancer. NEJM Evid. 2023 Jan;2(1):EVIDoa2200167.Full text  Abstract

113. Zhou L, Liang X, Zhang K. Assessment of the clinical efficacy of simultaneous transurethral resection of both bladder cancer and the prostate: a systematic review and meta-analysis. Aging Male. 2020 Dec;23(5):1182-93.Full text  Abstract

114. Neuzillet Y, Audenet F, Loriot Y, et al. French AFU Cancer Committee Guidelines - Update 2022-2024: muscle-Invasive bladder cancer (MIBC). Prog Urol. 2022 Nov;32(15):1141-63.Full text  Abstract

115. Powles T, Catto JWF, Galsky MD, et al. Perioperative durvalumab with neoadjuvant chemotherapy in operable badder cancer. N Engl J Med. 2024 Nov 14;391(19):1773-86. Abstract

116. Advanced Bladder Cancer Meta-analysis Collaboration. Neo-adjuvant chemotherapy for invasive bladder cancer. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD005246.Full text  Abstract

117. Gandaglia G, Popa I, Abdollah F, et al. The effect of neoadjuvant chemotherapy on perioperative outcomes in patients who have bladder cancer treated with radical cystectomy: a population-based study. Eur Urol. 2014 Sep;66(3):561-8. Abstract

118. Galsky MD, Pal SK, Chowdhury S, et al. Comparative effectiveness of gemcitabine plus cisplatin versus methotrexate, vinblastine, doxorubicin, plus cisplatin as neoadjuvant therapy for muscle-invasive bladder cancer. Cancer. 2015 Aug 1;121(15):2586-93.Full text  Abstract

119. Yin M, Joshi M, Meijer RP, et al. Neoadjuvant chemotherapy for muscle-invasive bladder cancer: a systematic review and two-step meta-analysis. Oncologist. 2016 Jun;21(6):708-15.Full text  Abstract

120. Aydh A, Sari Motlagh R, Alamri A, et al. Comparison between different neoadjuvant chemotherapy regimens and local therapy alone for bladder cancer: a systematic review and network meta-analysis of oncologic outcomes. World J Urol. 2023 Aug;41(8):2185-94.Full text  Abstract

121. Zargar H, Shah JB, van Rhijn BW, et al. Neoadjuvant dose dense MVAC versus gemcitabine and cisplatin in patients with cT3-4aN0M0 bladder cancer treated with radical cystectomy. J Urol. 2018 Jun;199(6):1452-8. Abstract

122. Sternberg CN, de Mulder PH, Schornagel JH, et al. Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924. J Clin Oncol. 2001 May 15;19(10):2638-46.Full text  Abstract

123. Martini A, Jia R, Ferket BS, et al. Tumor downstaging as an intermediate endpoint to assess the activity of neoadjuvant systemic therapy in patients with muscle-invasive bladder cancer. Cancer. 2019 Sep 15;125(18):3155-63.Full text  Abstract

124. Bruins HM, Veskimae E, Hernandez V, et al. The impact of the extent of lymphadenectomy on oncologic outcomes in patients undergoing radical cystectomy for bladder cancer: a systematic review. Eur Urol. 2014 Dec;66(6):1065-77. Abstract

125. Lerner SP, Tangen C, Svatek RS, et al. Standard or extended lymphadenectomy for muscle-invasive bladder cancer. N Engl J Med. 2024 Oct 3;391(13):1206-16.Full text  Abstract

126. American Urological Association. Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline. Apr 2024 [internet publication].Full text

127. Leow JJ, Martin-Doyle W, Rajagopal PS, et al. Adjuvant chemotherapy for invasive bladder cancer: a 2013 updated systematic review and meta-analysis of randomized trials. Eur Urol. 2014 Jul;66(1):42-54.Full text  Abstract

128. Iwata T, Kimura S, Abufaraj M, et al. The role of adjuvant radiotherapy after surgery for upper and lower urinary tract urothelial carcinoma: A systematic review. Urol Oncol. 2019 Oct;37(10):659-671.Full text  Abstract

129. Bajorin DF, Witjes JA, Gschwend JE, et al. Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma. N Engl J Med. 2021 Jun 3;384(22):2102-14. Abstract

130. Apolo AB, Ballman KV, Sonpavde G, et al. Adjuvant pembrolizumab versus observation in muscle-invasive urothelial carcinoma. N Engl J Med. 2025 Jan 2;392(1):45-55. Abstract

131. Advanced Bladder Cancer (ABC) Meta-analysis Collaborators Group. Adjuvant chemotherapy for muscle-invasive bladder cancer: a systematic review and meta-analysis of individual participant data from randomised controlled trials. Eur Urol. 2022 Jan;81(1):50-61.Full text  Abstract

132. Fonteyne V, Dirix P, Van Praet C, et al. Adjuvant radiotherapy after radical cystectomy for patients with high-risk muscle-invasive bladder cancer: results of a multicentric phase II trial. Eur Urol Focus. 2022 Sep;8(5):1238-45.Full text  Abstract

133. Murthy V, Maitre P, Bakshi G, et al. Bladder adjuvant radiation therapy (BART): acute and late toxicity from a phase III multicenter randomized controlled trial. Int J Radiat Oncol Biol Phys. 2025 Mar 1;121(3):728-36. Abstract

134. Powles T, Bellmunt J, Comperat E, et al. Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Mar;33(3):244-58.Full text  Abstract

135. Ding H, Fan N, Ning Z, et al. Trimodal therapy vs. radical cystectomy for muscle-invasive bladder cancer: a meta-analysis. Front Oncol. 2020;10:564779.Full text  Abstract

136. Damaj N, Naim N, Saad A, et al. Management of bladder cancer recurrence following the trimodality therapy. Front Oncol. 2025;15:1672431.Full text  Abstract

137. National Institute for Health and Care Excellence. Avelumab for maintenance treatment of locally advanced or metastatic urothelial cancer after platinum-based chemotherapy. May 2022 [internet publication].Full text

138. Powles T, Park SH, Voog E, et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N Engl J Med. 2020 Sep 24;383(13):1218-30.Full text  Abstract

139. Powles T, Bellmunt J, Comperat E, et al. ESMO Clinical Practice Guideline interim update on first-line therapy in advanced urothelial carcinoma. Ann Oncol. 2024 Jun;35(6):485-90.Full text  Abstract

140. Hoimes CJ, Flaig TW, Milowsky MI, et al. Enfortumab vedotin plus pembrolizumab in previously untreated advanced urothelial cancer. J Clin Oncol. 2023 Jan 1;41(1):22-31.Full text  Abstract

141. Powles T, Valderrama BP, Gupta S, et al. Enfortumab vedotin and pembrolizumab in untreated advanced urothelial cancer. N Engl J Med. 2024 Mar 7;390(10):875-88.Full text  Abstract

142. van der Heijden MS, Sonpavde G, Powles T, et al. Nivolumab plus gemcitabine-cisplatin in advanced urothelial carcinoma. N Engl J Med. 2023 Nov 9;389(19):1778-89.Full text  Abstract

143. Merseburger AS, Apolo AB, Chowdhury S, et al. SIU-ICUD recommendations on bladder cancer: systemic therapy for metastatic bladder cancer. World J Urol. 2019 Jan;37(1):95-105. Abstract

144. Galsky MD, Hahn NM, Rosenberg J, et al. A consensus definition of patients with metastatic urothelial carcinoma who are unfit for cisplatin-based chemotherapy. Lancet Oncol. 2011 Mar;12(3):211-4. Abstract

145. Balar AV, Galsky MD, Rosenberg JE, et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet. 2017 Jan 7;389(10064):67-76. Abstract

146. Bamias A, Davis ID, Galsky MD, et al. Atezolizumab monotherapy versus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis from a randomised, controlled, phase 3 study. Lancet Oncol. 2024 Jan;25(1):46-61. Abstract

147. Balar AV, Castellano D, O'Donnell PH, et al. First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study. Lancet Oncol. 2017 Nov;18(11):1483-92. Abstract

148. Abufaraj M, Dalbagni G, Daneshmand S, et al. The role of surgery in metastatic bladder cancer: a systematic review. Eur Urol. 2018 Apr;73(4):543-57.Full text  Abstract

149. ​Bellmunt J, de Wit R, Vaughn DJ, et al; KEYNOTE-045 Investigators. Pembrolizumab as second-line therapy for advanced urothelial carcinoma. N Engl J Med. 2017 Mar 16;376(11):1015-1026.Full text  Abstract

150. Powles T, Rosenberg JE, Sonpavde GP, et al. Enfortumab vedotin in previously treated advanced urothelial carcinoma. N Engl J Med. 2021 Mar 25;384(12):1125-35. Abstract

151. National Institute for Health and Care Excellence. Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy. April 2021 [internet publication].Full text

152. National Institute for Health and Care Excellence. ​Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy. July 2018 [internet publication].Full text

153. Loriot Y, Matsubara N, Park SH, et al. Erdafitinib or chemotherapy in advanced or metastatic urothelial carcinoma. N Engl J Med. 2023 Nov 23;389(21):1961-71.Full text  Abstract

154. ​Siefker-Radtke AO, Necchi A, Park SH, et al.; BLC2001 Study Group. Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study. Lancet Oncol. 2022 Feb;23(2):248-58. Abstract

155. Meric-Bernstam F, Makker V, Oaknin A, et al. Efficacy and safety of trastuzumab deruxtecan in patients with HER2-expressing solid tumors: primary results from the DESTINY-PanTumor02 phase II trial. J Clin Oncol. 2024 Jan 1;42(1):47-58.Full text  Abstract

156. ClinicalTrials.gov. A study of TAR-200 in combination with cetrelimab, TAR-200 alone, or cetrelimab alone in participants with non-muscle invasive bladder cancer (NMIBC) unresponsive to intravesical Bacillus Calmette-Guérin who are ineligible for or elected not to undergo radical cystectomy (SunRISe-1). ClinicalTrials.gov Identifier: NCT04640623. Dec 2025 [internet publication]​.Full text

157. ClinicalTrials.gov. A study of TAR-200 in combination with cetrelimab or TAR-200 alone versus intravesical Bacillus Calmette-Guérin (BCG) in participants with BCG-naïve high-risk non-muscle invasive bladder cancer (HR-NMIBC) (SunRISe-3). ClinicalTrials.gov Identifier: NCT05714202. Dec 2025 [internet publication]​.Full text

158. ClinicalTrials.gov. A study of TAR-200 versus intravesical chemotherapy in participants with recurrent high-risk non-muscle-invasive bladder cancer (HR-NMIBC) after Bacillus Calmette-Guérin (BCG) (SunRISe-5). ClinicalTrials.gov Identifier: NCT06211764. Dec 2025 [internet publication]​.Full text

159. ClinicalTrials.gov. A study of TAR-200 in combination with cetrelimab and cetrelimab alone in participants with muscle-invasive urothelial carcinoma of the bladder (SunRISe-4). ClinicalTrials.gov Identifier: NCT04919512. Dec 2025 [internet publication]​.Full text

160. Necchi A, Guerrero-Ramos F, Crispen PL, et al. TAR-200 plus cetrelimab versus cetrelimab monotherapy as neoadjuvant therapy in patients with muscle-invasive bladder cancer who are ineligible for or decline neoadjuvant cisplatin-based chemotherapy (SunRISe-4): interim analysis of a randomised, open-label phase 2 trial. Lancet Oncol. 2025 Oct;26(10):1312-22. Abstract

161. ClinicalTrials.gov. Study of cretostimogene given in patients with non-muscle invasive bladder cancer ,unresponsive to Bacillus-Calmette-Guerin (BOND-003). ClinicalTrials.gov Identifier: NCT04452591. Jul 2025 [internet publication]​.Full text

162. ClinicalTrials.gov. A study of adjuvant cretostimogene grenadenorepvec for treatment of intermediate risk NMIBC following TURBT. ClinicalTrials.gov Identifier:​ NCT06111235. Sep 2025 [internet publication]​.Full text

163. Sheng X, Wang L, He Z, et al. Efficacy and safety of disitamab vedotin in patients with human epidermal growth factor receptor 2-positive locally advanced or metastatic urothelial carcinoma: a combined analysis of two phase II clinical trials. J Clin Oncol. 2024 Apr 20;42(12):1391-402.Full text  Abstract

164. Sheng X, Zeng G, Zhang C, et al. Disitamab vedotin plus toripalimab in HER2-expressing advanced urothelial cancer. N Engl J Med. 2025 Dec 11;393(23):2324-37. Abstract

165. Angulo JC, Álvarez-Ossorio JL, Domínguez-Escrig JL, et al. Hyperthermic mitomycin C in intermediate-risk non-muscle-invasive bladder cancer: results of the HIVEC-1 Trial. Eur Urol Oncol. 2023 Feb;6(1):58-66. Abstract

166. Tan WS, Prendergast A, Ackerman C, et al. Adjuvant intravesical chemohyperthermia versus passive chemotherapy in patients with intermediate-risk non-muscle-invasive bladder cancer (HIVEC-II): a phase 2, open-label, randomised controlled trial. Eur Urol. 2023 Jun;83(6):497-504.Full text  Abstract

167. Lin W, Pan X, Zhang C, et al. Impact of age at diagnosis of bladder cancer on survival: a surveillance, epidemiology, and end results-based study 2004-2015. Cancer Control. 2023 Jan-Dec;30:10732748231152322.Full text  Abstract

168. Kwan ML, Garren B, Nielsen ME, et al. Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer. Urol Oncol. 2019 Jun;37(6):380-6.Full text  Abstract

169. Dursun F, Elshabrawy A, Wang H, et al. Histological variants of non-muscle invasive bladder cancer: survival outcomes of radical cystectomy vs. bladder preservation therapy. Urol Oncol. 2022 Jun;40(6):275.e1-275.e10. Abstract

170. Sood A, Rudzinski JK, Labbate CV, et al. Long-term oncological outcomes in patients diagnosed with nonmetastatic plasmacytoid variant of bladder cancer: a 20-year University of Texas MD Anderson Cancer Center experience. J Urol. 2024 Feb;211(2):241-55. Abstract

171. McFadden J, Tachibana I, Adra N, et al. Impact of variant histology on upstaging and survival in patients with nonmuscle invasive bladder cancer undergoing radical cystectomy. Urol Oncol. 2024 Mar;42(3):69.e11-69.e16. Abstract

172. Lamm D, Colombel M, Persad R, et al. Clinical practice recommendations for the management of non-muscle invasive bladder cancer. Eur Urol. 2008 Oct 1;7(10):651-66.

173. Gudjonsson S, Adell L, Merdasa F, et al. Should all patients with non-muscle-invasive bladder cancer receive early intravesical chemotherapy after transurethral resection? The results of a prospective randomised multicentre study. Eur Urol. 2009 Apr;55(4):773-80. Abstract

174. Malmstrom PU, Sylvester RJ, Crawford DE, et al. An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guerin for non-muscle-invasive bladder cancer. Eur Urol. 2009 Aug;56(2):247-56. Abstract

175. Cambier S, Sylvester RJ, Collette L, et al. EORTC nomograms and risk groups for predicting recurrence, progression, and disease-specific and overall survival in non-muscle-invasive stage Ta-T1 urothelial bladder cancer patients treated with 1-3 years of maintenance Bacillus Calmette-Guérin. Eur Urol. 2016 Jan;69(1):60-9. Abstract

176. Lamm DL, Riggs DR, Traynelis CT, et al. Apparent failure of current intravesical chemotherapy prophylaxis to influence the long term course of superficial transitional cell carcinoma of the bladder. J Urol. 1995 May;153(5):1444-50. Abstract

177. Rhea LP, Mendez-Marti S, Kim D, et al. Role of immunotherapy in bladder cancer. Cancer Treat Res Commun. 2021;26:100296.Full text  Abstract

178. Soria F, Mosca A, Gontero P. Drug strategies for bladder cancer in the elderly: is there promise for the future? Expert Opin Pharmacother. 2019 Aug;20(11):1387-96. Abstract

179. Martini A, Sfakianos JP, Renström-Koskela L, et al. The natural history of untreated muscle-invasive bladder cancer. BJU Int. 2020 Feb;125(2):270-5. Abstract

180. Skinner EC. Treatment of muscle-invasive bladder cancer in older patients. Am Soc Clin Oncol Educ Book. 2016;35:e228-33.Full text  Abstract

181. Kessler ER, Kukreja JB, Geiger CL, et al. Treating elderly patients with muscle-invasive bladder cancer. J Natl Compr Canc Netw. 2020 Jun;18(6):783-90.Full text  Abstract

182. Golijanin DJ, Kakiashvili D, Madeb RR, et al. Chemoprevention of bladder cancer. World J Urol. 2006 Nov;24(5):445-72. Abstract

183. Picozzi S, Ricci C, Gaeta M, et al. Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients. J Urol. 2012 Dec;188(6):2046-54.Full text  Abstract

184. Cusano A, Murphy G, Haddock P, et al. Tumour seeding as a result of intraperitoneal perforation during transurethral resection of non-muscle invasive bladder cancer. BMJ Case Rep. 2014 Sep 24;2014:bcr2014206631. Abstract

185. Hussein AA, May PR, Jing Z, et al. Outcomes of intracorporeal urinary diversion after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. J Urol. 2018 May;199(5):1302-11. Abstract

186. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: management of Immune Checkpoint Inhibitor-Related Toxicities [internet publication].Full text

187. Brahmer JR, Abu-Sbeih H, Ascierto PA, et al. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events. J Immunother Cancer. 2021 Jun;9(6):e002435.Full text  Abstract

188. Palou J, Rodríguez-Rubio F, Millán F, et al. Recurrence at three months and high-grade recurrence as prognostic factor of progression in multivariate analysis of T1G2 bladder tumors. Urology. 2009 Jun;73(6):1313-7. Abstract

189. Mori K, Abufaraj M, Mostafaei H, et al. A systematic review and meta-analysis of variant histology in urothelial carcinoma of the bladder treated with radical cystectomy. J Urol. 2020 Dec;204(6):1129-40.Full text  Abstract

190. Zhang YB, Pan XF, Chen J, et al. Combined lifestyle factors, incident cancer, and cancer mortality: a systematic review and meta-analysis of prospective cohort studies. Br J Cancer. 2020 Mar;122(7):1085-93.Full text  Abstract

191. Gottlieb J, Higley C, Sosnowski R, et al. Smoking-related genitourinary cancers: a global call to action in smoking cessation. Rev Urol. 2016;18(4):194-204.Full text  Abstract

192. Xiang L, Xie QQ, Xu SS, et al. Association between tobacco exposure and bladder cancer recurrence: a systematic review and meta-analysis. World J Methodol. 2024 Jun 20;14(2):91889.Full text  Abstract

193. Ślusarczyk A, Zapała P, Zapała Ł, et al. The impact of smoking on recurrence and progression of non-muscle invasive bladder cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2023 Jun;149(6):2673-91.Full text  Abstract

194. Hu J, Chen JB, Cui Y, et al. Association of metformin intake with bladder cancer risk and oncologic outcomes in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Medicine (Baltimore). 2018 Jul;97(30):e11596.Full text  Abstract

195. Nayan M, Bhindi B, Yu JL, et al. The effect of metformin on cancer-specific survival outcomes in diabetic patients undergoing radical cystectomy for urothelial carcinoma of the bladder. Urol Oncol. 2015 Sep;33(9):386.e7-13. Abstract

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