Prognosis

Median survival from diagnosis of FTD has been reported to be 7-13 years in clinic cohorts and 6-8 years in neuropathology series.[134][135][136][137] Generally, survival times from diagnosis have been reported to be similar in patients with behavioral variant FTD (bvFTD), nonfluent aphasia, corticobasal degeneration, or progressive supranuclear palsy.[138] However, one study indicated that life expectancy may be shorter in patients with bvFTD than in those with progressive nonfluent aphasia or semantic dementia.[139] Median survival is considerably shorter (3 years) in patients with FTD and concomitant motor neuron disease, although a subset survived for up to 5 years, and sudden death may be common.[135] Patients with FTD generally have shorter survival and faster rates of cognitive and functional decline than patients with Alzheimer disease.[140]

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