References

Key articles

Expert Panel on Neurological Imaging: Shih RY, Burns J, et al. ACR Appropriateness Criteria® head trauma: 2021 update. J Am Coll Radiol. 2021 May;18(5S):S13-36.Full text  Abstract

Reference articles

1. Pretto Flores L, De Almeida CS, Casulari LA. Positive predictive values of selected clinical signs associated with skull base fractures. J Neurosurg Sci. 2000 Jun;44(2):77-82. Abstract

2. Servadei F, Ciucci G, Pagano F, et al. Skull fracture as a risk factor of intracranial complications in minor head injuries: a prospective CT study in a series of 98 adult patients. J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):526-8. Abstract

3. Schutzman SA, Greenes DS. Pediatric minor head trauma. Ann Emerg Med. 2001 Jan;37(1):65-74. Abstract

4. GBD 2019 Fracture Collaborators. Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2021 Sep;2(9):e580-92.Full text  Abstract

5. Besenski N. Traumatic injuries: imaging of head injuries. Eur Radiol. 2002 Jun;12(6):1237-52. Abstract

6. Ersahin Y, Mutluer S, Mirzai H, et al. Pediatric depressed skull fractures: analysis of 530 cases. Childs Nerv Syst. 1996 Jun;12(6):323-31. Abstract

7. Mithani SK, St-Hilaire H, Brooke BS, et al. Predictable patterns of intracranial and cervical spine injury in craniomaxillofacial trauma: analysis of 4786 patients. Plast Reconstr Surg. 2009 Apr;123(4):1293-301. Abstract

8. Smits M, Dippel DW, de Haan GG, et al. Minor head injury: guidelines for the use of CT - a multicenter validation study. Radiology. 2007 Dec;245(3):831-8. Abstract

9. Galarneau MR, Woodruff SI, Dye JL, et al. Traumatic brain injury during Operation Iraqi Freedom: findings from the United States Navy-Marine Corps Combat Trauma Registry. J Neurosurg. 2008 May;108(5):950-7. Abstract

10. Shane SA, Fuchs SM. Skull fractures in infants and predictors of associated intracranial injury. Pediatr Emerg Care. 1997 Jun;13(3):198-203. Abstract

11. Macpherson BC, MacPherson P, Jennett B. CT evidence of intracranial contusion and haematoma in relation to the presence, site and type of skull fracture. Clin Radiol. 1990 Nov;42(5):321-6. Abstract

12. Al-Haddad SA, Kirollos R. A 5-year study of the outcome of surgically treated depressed skull fractures. Ann R Coll Surg Engl. 2002 May;84(3):196-200.Full text  Abstract

13. Bradford R, Choudhary AK, Dias MS. Serial neuroimaging in infants with abusive head trauma: timing abusive injuries. J Neurosurg Pediatr. 2013 Aug;12(2):110-9.Full text  Abstract

14. Feldman KW, Bethel R, Shugerman RP, et al. The cause of infant and toddler subdural hemorrhage: a prospective study. Pediatrics. 2001 Sep;108(3):636-46.Full text  Abstract

15. King WJ, MacKay M, Sirnick A, et al. Shaken baby syndrome in Canada: clinical characteristics and outcomes of hospital cases. CMAJ. 2003 Jan 21;168(2):155-9.Full text  Abstract

16. Narang SK, Haney S, Duhaime AC, et al. Abusive head trauma in infants and children: technical report. Pediatrics. 2025 Mar 1;155(3):e2024070457.Full text

17. American College of Surgeons. Best practice guidelines: geriatric trauma management. Nov 2023 [internet publication].Full text

18. Hymel KP, Armijo-Garcia V, Foster R, et al. Validation of a clinical prediction rule for pediatric abusive head trauma. Pediatrics. 2014 Dec;134(6):e1537-44. Abstract

19. Cowley LE, Morris CB, Maguire SA, et al. Validation of a prediction tool for abusive head trauma. Pediatrics. 2015 Aug;136(2):290-8. Abstract

20. Jandial R, Reichwage B, Levy M, et al. Ballistics for the neurosurgeon. Neurosurgery. 2008 Feb;62(2):472-80. Abstract

21. Centers for Disease Control and Prevention; National Center for Injury Prevention and Control. Pediatric abusive head trauma: recommended definitions for public health surveillance and research. Apr 2012 [internet publication].Full text

22. McIntosh AS, McCrory P, Finch CF, et al. Does padded headgear prevent head injury in rugby union football? Med Sci Sports Exerc. 2009 Feb;41(2):306-13. Abstract

23. McIntosh AS, McCrory P. Preventing head and neck injury. Br J Sports Med. 2005 Jun;39(6):314-8. Abstract

24. Macnab AJ, Smith T, Gagnon FA, et al. Effect of helmet wear on the incidence of head/face and cervical spine injuries in young skiers and snowboarders. Inj Prev. 2002 Dec;8(4):324-7. Abstract

25. Rughani AI, Lin CT, Ares WJ, et al. Helmet use and reduction in skull fractures in skiers and snowboarders admitted to the hospital. J Neurosurg Pediatr. 2011 Mar;7(3):268-71. Abstract

26. Bergenstal J, Davisk SM, Sikor R, et al. Pediatric bicycle injury prevention and the effect of helmet use: the West Virginia experience. W V Med J. 2012 May-Jun;108(6):78-81. Abstract

27. Miller M, Davidov D, Tillotson R, et al. Injury prevention and recreational all-terrain vehicle use: the impact of helmet use in West Virginia. W V Med J. 2012 May-Jun;108(3):96-101. Abstract

28. American College of Surgeons. Statement on bicycle safety and the promotion of bicycle helmet use. Mar 2023 [internet publication].Full text

29. Bowman SM, Aitken ME, Helmkamp JC, et al. Impact of helmets on injuries to riders of all-terrain vehicles. Inj Prev. 2009 Feb;15(1):3-7. Abstract

30. Liu B, Ivers R, Norton R, et al. Helmets for preventing injury in motorcycle riders. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD004333.Full text  Abstract

31. Thompson DC, Rivara FP, Thompson R. Helmets for preventing head and facial injuries in bicyclists. Cochrane Database Syst Rev. 1999;(4):CD001855.Full text  Abstract

32. Missliwetz J, Wieser I. Gunshot wounds of the head in soldiers wearing military helmets - general aspects and experiments and observations on the biomechanics and wound morphology [in German]. Z Rechtsmed. 1989;102(1):41-54. Abstract

33. Barlow J, Simkiss D, Stewart Brown S. Interventions to prevent or ameliorate child physical abuse and neglect, findings from a systematic review. J Child Services. 2006;1(3):6-28.

34. Dias MS, Smith K, DeGuehery K, et al. Preventing abusive head trauma among infants and young children: a hospital-based, parent education program. Pediatrics. 2005 Apr;115(4):e470-7. Abstract

35. National Institute for Health and Care Excellence. Head injury: assessment and early management. May 2023 [internet publication].​Full text

36. Haydel MJ, Preston CA, Mills TJ, et al. Indications for computed tomography in patients with minor head injury. N Engl J Med. 2000 Jul 13;343(2):100-5.Full text  Abstract

37. Stiell IG, Wells GA, Vandemheen K, et al. The Canadian CT head rule for patients with minor head injury. Lancet. 2001 May 5;357(9266):1391-6. Abstract

38. Haney S, Scherl S, DiMeglio L, et al. Evaluating young children with fractures for child abuse: clinical report. Pediatrics. 2025 Feb 1;155(2):e2024070074.Full text  Abstract

39. Hymel KP, Lee G, Boos S, et al. Estimating the relevance of historical red flags in the diagnosis of abusive head trauma. J Pediatr. 2020 Mar;218:178-83.Full text  Abstract

40. Gravel J, Gouin S, Chalut D, et al. Derivation and validation of a clinical decision rule to identify young children with skull fracture following isolated head trauma. CMAJ. 2015 Nov 3;187(16):1202-8.Full text  Abstract

41. Maguire S, Hunter B, Hunter L, et al. Diagnosing abuse: a systematic review of torn frenum and other intra-oral injuries. Arch Dis Child. 2007 Dec;92(12):1113-7. Abstract

42. Caré MM. Macrocephaly and subdural collections. Pediatr Radiol. 2021 May;51(6):891-7. Abstract

43. Bhardwaj G, Chowdhury V, Jacobs MB, et al. A systematic review of the diagnostic accuracy of ocular signs in pediatric abusive head trauma. Ophthalmology. 2010 May;117(5):983-92. Abstract

44. Dula D, Fales W. The "ring sign:" is it a reliable indicator for cerebral spinal fluid? Ann Emerg Med. 1993 Apr;22(4):718-20. Abstract

45. Teasdale G, Jennett B. Assessment of coma and impaired consciousness: a practical scale. Lancet. 1974 Jul 13;2(7872):81-4. Abstract

46. Roguski M, Morel B, Sweeney M, et al. Magnetic resonance imaging as an alternative to computed tomography in select patients with traumatic brain injury: a retrospective comparison. J Neurosurg Pediatr. 2015 May;15(5):529-34. Abstract

47. Mulroy MH, Loyd AM, Frush DP, et al. Evaluation of pediatric skull fracture imaging techniques. Forensic Sci Int. 2012 Jun 10;214(1-3):167-72. Abstract

48. Expert Panel on Neurological Imaging: Shih RY, Burns J, et al. ACR Appropriateness Criteria® head trauma: 2021 update. J Am Coll Radiol. 2021 May;18(5S):S13-36.Full text  Abstract

49. Orman G, Wagner MW, Seeburg D, et al. Pediatric skull fracture diagnosis: should 3D CT reconstructions be added as routine imaging? J Neurosurg Pediatr. 2015 Oct;16(4):426-31. Abstract

50. Provenzale J. CT and MR imaging of acute cranial trauma. Emerg Radiol. 2007 Apr;14(1):1-12. Abstract

51. Ringl H, Schernthaner R, Philipp MO, et al. Three-dimensional fracture visualisation of multidetector CT of the skull base in trauma patients: comparison of three reconstruction algorithms. Eur Radiol. 2009 Oct;19(10):2416-24. Abstract

52. Ringl H, Schernthaner RE, Schueller G, et al. The skull unfolded: a cranial CT visualization algorithm for fast and easy detection of skull fractures. Radiology. 2010 May;255(2):553-62. Abstract

53. Bruce DA. Imaging after head trauma: why, when and which. Childs Nerv Syst. 2000 Nov;16(10-11):755-9. Abstract

54. Dempewolf R, Gubbels S, Hansen MR. Acute radiographic workup of blunt temporal bone trauma: maxillofacial versus temporal bone CT. Laryngoscope. 2009 Mar;119(3):442-8. Abstract

55. Zhao X, Rizzo A, Malek B, et al. Basilar skull fracture: a risk factor for transverse/sigmoid venous sinus obstruction. J Neurotrauma. 2008 Feb;25(2):104-11. Abstract

56. Donovan DJ. Simple depressed skull fracture causing sagittal sinus stenosis and increased intracranial pressure: case report and review of the literature. Surg Neurol. 2005 Feb;63(2):380-3. Abstract

57. Parri N, Crosby BJ, Glass C, et al. Ability of emergency ultrasonography to detect pediatric skull fractures: a prospective, observational study. J Emerg Med. 2013 Apr;44(2):135-41.Full text  Abstract

58. Rabiner JE, Friedman LM, Khine H, et al. Accuracy of point-of-care ultrasound for diagnosis of skull fractures in children. Pediatrics. 2013 Jun;131(6):e1757-64. Abstract

59. Masaeli M, Chahardoli M, Azizi S, et al. Point of care ultrasound in detection of brain hemorrhage and skull fracture following pediatric head trauma; a diagnostic accuracy study. Arch Acad Emerg Med. 2019 Sep 24;7(1):e53.Full text  Abstract

60. Kim PD, Jennings JS, Fisher M, et al. Risk of cervical spine injury and other complications seen with skull fractures in the setting of mild closed head injury in young children: a retrospective study. Pediatr Neurosurg. 2008;44(2):124-7. Abstract

61. Oller DW, Meredith JW, Rutledge R, et al. The relationship between face or skull fractures and cervical spine and spinal cord injuries: a review of 13,834 patients. Acid Anal Prev. 1992 Apr;24(2):1887-92. Abstract

62. Expert Panel on Pediatric Imaging: Wootton-Gorges SL, Soares BP, et al. ACR Appropriateness Criteria® suspected physical abuse-child. J Am Coll Radiol. 2017 May;14(5s):S338-49.Full text  Abstract

63. American College of Radiology. ACR–SPR practice parameter for the performance and interpretation of skeletal surveys in children. 2021 [internet publication].Full text

64. Section on Radiology, American Academy of Pediatrics. Diagnostic imaging of child abuse. Pediatrics. 2009 May;123(5):1430-5.Full text  Abstract

65. Bokhari R, You E, Bakhaidar M, et al. Dural venous sinus thrombosis in patients presenting with blunt traumatic brain injuries and skull fractures: a systematic review and meta-analysis. World Neurosurg. 2020 Oct;142:495-505.e3. Abstract

66. Abuabara A. Cerebrospinal fluid rhinorrhoea: diagnosis and management. Med Oral Patol Oral Cir Bucal. 2007 Sep 1;12(5):E397-400.Full text  Abstract

67. Zaman S, Logan PH, Landes C, et al. Soft-tissue evidence of head injury in infants and young children: is CT head examination justified? Clin Radiol. 2017 Apr;72(4):316-22. Abstract

68. Hendrickson S, Murahari S, Scotter J, et al. Venous sinus injuries are common with occipital skull fractures. Scand J Trauma Resusc Emerg Med. 2014 Jul 7;22(suppl 1):O8.Full text

69. American College of Radiology. ACR Appropriateness Criteria® head trauma-child. 2018 [internet publication].Full text

70. Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 5;172(11):e182853. Abstract

71. Bonfield CM, Naran S, Adetayo OA, et al. Pediatric skull fractures: the need for surgical intervention, characteristics, complications, and outcomes. J Neurosurg Pediatr. 2014 Aug;14(2):205-11. Abstract

72. Demetriades D, Charalambides D, Lakhoo M, et al. Role of prophylactic antibiotics in open and basilar fractures of the skull: a randomized study. Injury. 1992;23(6):377-80. Abstract

73. Ratilal BO, Costa J, Pappamikail L, et al. Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database Syst Rev. 2015 Apr 28;(4):CD004884.Full text  Abstract

74. Rehman L, Ghani E, Hussain A, et al. Infection in compound depressed fracture of the skull. J Coll Physicians Surg Pak. 2007 Mar;17(3):140-3. Abstract

75. Nellis JC, Kesser BW, Park SS. What is the efficacy of prophylactic antibiotics in basilar skull fractures? Laryngoscope. 2014 Jan;124(1):8-9.Full text  Abstract

76. Tunkel AR, Hasbun R, Bhimraj A, et al. 2017 Infectious Diseases Society of America's clinical practice guidelines for healthcare-associated ventriculitis and meningitis. Clin Infect Dis. 2017 Mar 15;64(6):e34-65.Full text  Abstract

77. Venetz I, Schopfer K, Mühlemann K. Paediatric, invasive pneumococcal disease in Switzerland, 1985-1994. Swiss Pneumococcal Study Group. Int J Epidemiol. 1998 Dec;27(6):1101-4. Abstract

78. Kaptigau WM, Ke L, Rosenfeld JV. Open depressed and penetrating skull fractures in Port Moresby General Hospital from 2003 to 2005. P N G Med J. 2007 Mar-Jun;50(1-2):58-63. Abstract

79. Heary RF, Hunt CD, Krieger AJ, et al. Nonsurgical treatment of compound depressed skull fractures. J Trauma. 1993 Sep;35(3):441-7. Abstract

80. Marbacher S, Andres RH, Fathi AR, et al. Primary reconstruction of open depressed skull fractures with titanium mesh. J Craniofac Surg. 2008 Mar;19(2):490-5. Abstract

81. Bullock MR, Chesnut R, Ghajar J, et al; Surgical Management of Traumatic Brain Injury Author Group. Surgical management of depressed cranial fractures. Neurosurgery. 2006 Mar;58(3 suppl):S56-60. Abstract

82. Wylen EL, Willis BK, Nanda A. Infection rate with replacement of bone fragment in compound depressed skull fractures. Surg Neurol. 1999 Apr;51(4):452-7. Abstract

83. Yetiser S, Hidir Y, Gonul E. Facial nerve problems and hearing loss in patients with temporal bone fractures: demographic data. J Trauma. 2008 Dec;65(6):1314-20. Abstract

84. Dalgic A, Okay HO, Gezici AR, et al. An effective and less invasive treatment of post-traumatic cerebrospinal fluid fistula: closed lumbar drainage system. Minim Invasive Neurosurg. 2008 Jun;51(3):154-7. Abstract

85. Nash JJ, Friedland DR, Boorsma KJ, et al. Management and outcomes of facial paralysis from intratemporal blunt trauma: a systematic review. Laryngoscope. 2010 Jul;120(7):1397-404. Abstract

86. Sherif C, Di leva A, Gibson D, et al. A management algorithm for cerebrospinal fluid leak associated with anterior skull base fractures: detailed clinical and radiological follow-up. Neurosurg Rev. 2012 Apr;35(2):227-37;discussion 237-8. Abstract

87. Phang SY, Whitehouse K, Lee L, et al. Management of CSF leak in base of skull fractures in adults. Br J Neurosurg. 2016 Dec;30(6):596-604. Abstract

88. Yilmazlar S, Arslan E, Kocaeli H, et al. Cerebrospinal fluid leakage complicating skull base fractures: analysis of 81 cases. Neurosurg Rev. 2006 Jan;29(1):64-71. Abstract

89. Liesemer K, Bratton SL, Zebrack CM, et al. Early post-traumatic seizures in moderate to severe pediatric traumatic brain injury: rates, risk factors, and clinical features. J Neurotrauma. 2011 May;28(5):755-62. Abstract

90. Beghi E. Overview of studies to prevent posttraumatic epilepsy. Epilepsia. 2003;44(s10):21-6. Abstract

91. Temkin NR. Preventing and treating posttraumatic seizures: the human experience. Epilepsia. 2009 Feb;50(suppl 2):10-3. Abstract

92. Chang BS, Lowenstein DH; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2003 Jan 14;60(1):10-6.Full text  Abstract

93. CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019 Nov 9;394(10210):1713-23.Full text  Abstract

94. Rowell SE, Meier EN, McKnight B, et al. Effect of out-of-hospital tranexamic acid vs placebo on 6-month functional neurologic outcomes in patients with moderate or severe traumatic brain injury. JAMA. 2020 Sep 8;324(10):961-74.Full text  Abstract

95. Umana GE, Pucci R, Palmisciano P, et al. Cerebrospinal fluid leaks after anterior skull base trauma: a systematic review of the literature. World Neurosurg. 2022 Jan;157:193-206.e2. Abstract

96. Sonig A, Thakur JD, Chittiboina P, et al. Is posttraumatic cerebrospinal fluid fistula a predictor of posttraumatic meningitis? A US nationwide inpatient sample database study. Neurosurg Focus. 2012 Jun;32(6):E4.Full text  Abstract

97. de Gans J, van de Beek D, European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002 Nov 14;347(20):1549-56. Abstract

98. Coello AF, Canals AG, Gonzalez JM, et al. Cranial nerve injury after minor head trauma. J Neurosurg. 2010 Sep;113(3):547-55. Abstract

99. Dunklebarger J, Branstetter B 4th, Lincoln A, et al. Pediatric temporal bone fractures: current trends and comparison of classification schemes. Laryngoscope. 2014 Mar;124(3):781-4. Abstract

100. Montava M, Mancini J, Masson C, et al. Temporal bone fractures: sequelae and their impact on quality of life. Am J Otolaryngol. 2015 May-Jun;36(3):364-70. Abstract

101. Liang W, Xiaofeng Y, Weiguo L, et al. Traumatic carotid cavernous fistula accompanying basilar skull fracture: a study on the incidence of traumatic carotid cavernous fistula in the patients with basilar skull fracture and the prognostic analysis about traumatic carotid cavernous fistula. J Trauma. 2007 Nov;63(5):1014-20; discussion 1020. Abstract

102. Ellis JA, Goldstein H, Connolly ES Jr, et al. Carotid-cavernous fistulas. Neurosurg Focus. 2012 May;32(5):E9.Full text  Abstract

103. Lopez Gomez P, Mato Mañas D, Torres Diez E, et al. Post-traumatic carotid-cavernous fistula. Pract Neurol. 2021 Jun;21(3):259-60. Abstract

104. Henderson AD, Miller NR. Carotid-cavernous fistula: current concepts in aetiology, investigation, and management. Eye (Lond). 2018 Feb;32(2):164-72.Full text  Abstract

105. Ottawa Hospital Research Institute. Living concussion guidelines: guideline for concussion and prolonged symptoms for adults 18 years of age or older. 2024 [internet publication].Full text

106. Sivori LA 2nd, de Leeuw R, Morgan I, et al. Complications of frontal sinus fractures with emphasis on chronic craniofacial pain and its treatment: a review of 43 cases. J Oral Maxillofac Surg. 2010 Sep;68(9):2041-6. Abstract

Comorbidities Manager reference articles

107. National Institute for Health and Care Excellence. Head injury: assessment and early management. May 2023 [internet publication].Full text

108. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Dec;6(12):681-94. Abstract

109. Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a stroke risk factor and determinant of outcome after stroke. Stroke. 2020 Oct;51(10):3156-68.Full text  Abstract

110. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13.Full text  Abstract

111. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 Jun;47(6):e98-169.Full text  Abstract

112. Shenvi C, Kennedy M, Austin CA, et al. Managing delirium and agitation in the older emergency department patient: the ADEPT tool. Ann Emerg Med. 2020 Feb;75(2):136-45.Full text  Abstract

113. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. Abstract

114. Tinetti M, Huang A, Molnar F. The Geriatrics 5M's: a new way of communicating what we do. J Am Geriatr Soc. 2017 Sep;65(9):2115.Full text  Abstract

115. Canadian Geriatrics Society. Update: Public launch of the geriatric 5Ms. 2017 [internet publication].Full text

116. Devlin JW, Skrobik Y, Gélinas C, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-73.Full text  Abstract

117. Zhang XM, Jiao J, Xie XH, et al. The Association Between Frailty and Delirium Among Hospitalized Patients: An Updated Meta-Analysis. J Am Med Dir Assoc. 2021 Mar;22(3):527-534.Full text  Abstract

118. Inouye SK, Schlesinger MJ, Lydon TJ. Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am J Med. 1999 May;106(5):565-73.Full text  Abstract

119. Han JH, Wilson A, Vasilevskis EE, et al. Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med. 2013 Nov;62(5):457-65. Abstract

120. American College of Emergency Physicians, American Geriatrics Society, Emergency Nurses Association, et al. Geriatric emergency department guidelines. Ann Emerg Med. 2014 May;63(5):e7-25.Full text  Abstract

121. Wei LA, Fearing MA, Sternberg EJ, et al. The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc. 2008 May;56(5):823-30. Abstract

122. National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. January 2023 [internet publication].Full text

123. Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001 Jul;29(7):1370-9. Abstract

124. Bergeron N, Dubois MJ, Dumont M, et al. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001 May;27(5):859-64. Abstract

125. American College of Surgeons. Best practice guidelines: geriatric trauma management. 2023 [internet publication].Full text

126. Bryant EA, Tulebaev S, Castillo-Angeles M, et al. Frailty identification and care pathway: an interdisciplinary approach to care for older trauma patients. J Am Coll Surg. 2019 Jun;228(6):852-9. Abstract

127. Cesari M, Calvani R, Marzetti E. Frailty in older persons. Clin Geriatr Med. 2017 Aug;33(3):293-303. Abstract

128. Rockwood K, British Geriatrics Society. Silver book II: frailty. February 2021 [internet publication].Full text

129. Joseph B, Phelan H, Hassan A, et al. The impact of frailty on failure-to-rescue in geriatric trauma patients: a prospective study. J Trauma Acute Care Surg. 2016 Dec;81(6):1150-5. Abstract

130. Joseph B, Pandit V, Zangbar B, et al. Superiority of frailty over age in predicting outcomes among geriatric trauma patients: a prospective analysis. JAMA Surg. 2014 Aug;149(8):766-72.Full text  Abstract

131. Engelhardt KE, Reuter Q, Liu J, et al. Frailty screening and a frailty pathway decrease length of stay, loss of independence, and 30-day readmission rates in frail geriatric trauma and emergency general surgery patients. J Trauma Acute Care Surg. 2018 Jul;85(1):167-73. Abstract

132. Joseph B, Pandit V, Zangbar B, et al. Validating trauma-specific frailty index for geriatric trauma patients: a prospective analysis. J Am Coll Surg. 2014 Jul;219(1):10-17.e1. Abstract

133. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005 Aug 30;173(5):489-95.Full text  Abstract

134. Church S, Rogers E, Rockwood K, et al. A scoping review of the Clinical Frailty Scale. BMC Geriatr. 2020 Oct 7;20(1):393.Full text  Abstract

135. Rockwood K, Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can Geriatr J. 2020 Sep;23(3):210-5.Full text  Abstract

136. American College of Surgeons. Best practices guidelines: spine injury. Mar 2022 [internet publication].Full text

137. The 2023 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023 Jul;71(7):2052-81.Full text  Abstract

138. Conroy SP, Bardsley M, Smith P, et al. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study. Southampton (UK): NIHR Journals Library; 2019 Apr.Full text  Abstract

139. Molnar F, Frank CC. Optimizing geriatric care with the GERIATRIC 5Ms. Can Fam Physician. 2019 Jan;65(1):39.Full text  Abstract

140. Miller RK, Young M, Chippendale R, et al. Using the Geriatric 5Ms to teach structural and social determinants of health. J Am Geriatr Soc. 2023 Dec;71(12):3967-72. Abstract

141. Jamshed N, Gangavati A. Prioritizing the 5Ms in geriatric care: a holistic approach to care of the older adult. Am Fam Physician. 2024 Jun;109(6):498-500.Full text  Abstract

142. Anderson WG, Berlinger N, Ragland J et al. Hospital-based prognosis and goals of care discussions with seriously ill patients: a pathway to integrate a key primary palliative care process into the workflow of hospitalist physicians and their teams. Society of Hospital Medicine and The Hastings Center, 2017 [internet publication].Full text

143. Secunda K, Wirpsa MJ, Neely KJ, et al. Use and meaning of "goals of care" in the healthcare literature: a systematic review and qualitative discourse analysis. J Gen Intern Med. 2020 May;35(5):1559-66.Full text  Abstract

144. Boyd C, Smith CD, Masoudi FA, et al. Decision making for older adults with multiple chronic conditions: executive summary for the American Geriatrics Society guiding principles on the care of older adults with multimorbidity. J Am Geriatr Soc. 2019 Apr;67(4):665-73. Abstract

145. Appelbaum PS. Clinical practice. Assessment of patients' competence to consent to treatment. N Engl J Med. 2007 Nov 1;357(18):1834-40. Abstract

146. Sulmasy LS, Bledsoe TA, ACP Ethics, Professionalism and Human Rights Committee. American College of Physicians ethics manual: seventh edition. Ann Intern Med. 2019 Jan 15;170(2_suppl):S1-32.Full text  Abstract

147. Barstow C, Shahan B, Roberts M. Evaluating medical decision-making capacity in practice. Am Fam Physician. 2018 Jul 1;98(1):40-6.Full text  Abstract

148. Dixon JD, Josyula AV, Javier NM, et al. American Geriatrics Society position statement: Making medical treatment decisions for unrepresented older adults. J Am Geriatr Soc. 2025 May;73(5):1353-1364.Full text  Abstract

149. Pope TM, Bennett J, Carson SS, et al. Making medical treatment decisions for unrepresented patients in the ICU. An official American Thoracic Society/American Geriatrics Society policy statement. Am J Respir Crit Care Med. 2020 May 15;201(10):1182-92.Full text  Abstract

150. Jonsen AR, Siegler M, Winslade WJ, eds. Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine. 9th ed. McGraw Hill; 2022

151. Nickel C, Arendts G, Lucke J, et al. Silver book II: Geriatric syndromes. February 2021 [internet publication].Full text

152. Yang ZC, Lin H, Jiang GH, et al. Frailty is a risk factor for falls in the older adults: a systematic review and meta-analysis. J Nutr Health Aging. 2023;27(6):487-595.Full text  Abstract

153. American College of Surgeons. ACS TQP best practices guidelines for trauma center recognition of child abuse, elder abuse, and intimate partner violence. 2019 [Internet publication].Full text

154. National Adult Protective Services Association. Help in your area.[internet publication].Full text

155. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13.Full text  Abstract

156. Silverman JJ, Galanter M, Jackson-Triche M, et al. The American Psychiatric Association practice guidelines for the psychiatric evaluation of adults. Am J Psychiatry. 2015 Aug 1;172(8):798-802.Full text  Abstract

157. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Abstract

158. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7.Full text  Abstract

159. Lapa ME, Swabe GM, Rollman BL, et al. Assessment of depression and adherence to guideline-drected medical therapies following percutaneous coronary intervention. JAMA Netw Open. 2022 Dec 1;5(12):e2246317.Full text  Abstract

160. Poletti V, Pagnini F, Banfi P, et al. The role of depression on treatment adherence in patients with heart failure-a systematic review of the literature. Curr Cardiol Rep. 2022 Dec;24(12):1995-2008.Full text  Abstract

161. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33.Full text  Abstract

162. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(s7):S54-60.Full text  Abstract

163. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes-2025. Diabetes Care. 2025 Jan 1;48(supplement_1):S321-34.Full text  Abstract

164. Blonde L, Umpierrez GE, Reddy SS, et al. American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan - 2022 update. Endocr Pract. 2022 Oct;28(10):923-1049.Full text  Abstract

165. US Food and Drug Administration. FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections. March 2022 [internet publication].Full text

166. Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

167. Honarmand K, Sirimaturos M, Hirshberg EL, et al. Society of Critical Care Medicine guidelines on glycemic control for critically ill children and adults 2024. Crit Care Med. 2024 Apr 1;52(4):e161-81.Full text  Abstract

168. Joint British Diabetes Societies for Inpatient Care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. October 2014 [internet publication].Full text

169. Lim Y, Ohn JH, Jeong J, et al. Effect of the concomitant use of subcutaneous basal insulin and intravenous insulin infusion in the treatment of severe hyperglycemic patients. Endocrinol Metab (Seoul). 2022 Jun;37(3):444-54.Full text  Abstract

170. Thammakosol K, Sriphrapradang C. Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: a randomized controlled trial. Diabetes Obes Metab. 2023 Mar;25(3):815-22. Abstract

171. Korytkowski MT, Muniyappa R, Antinori-Lent K, et al. Management of hyperglycemia in hospitalized adult patients in non-critical care settings: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2022 Jul 14;107(8):2101-28.Full text  Abstract

172. Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021 Jun;27(6):505-37.Full text  Abstract

173. Galindo RJ, Umpierrez GE, Rushakoff RJ, et al. Continuous glucose monitors and automated insulin dosing systems in the hospital consensus guideline. J Diabetes Sci Technol. 2020 Nov;14(6):1035-64.Full text  Abstract

174. American Diabetes Association Professional Practice Committee. 7. Diabetes Technology: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(supplement_1):S146-S166.Full text  Abstract

175. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88.Full text  Abstract

176. Galindo RJ, Dhatariya K, Gomez-Peralta F, et al. Safety and efficacy of inpatient diabetes management with non-insulin agents: an overview of international practices. Curr Diab Rep. 2022 Jun;22(6):237-46.Full text  Abstract

177. Khunti K, Aroda VR, Bhatt DL, et al. Re-examining the widespread policy of stopping sodium-glucose cotransporter-2 inhibitors during acute illness: a perspective based on the updated evidence. Diabetes Obes Metab. 2022 Nov;24(11):2071-80. Abstract

178. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67.Full text  Abstract

179. NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

180. Yamada T, Shojima N, Noma H, et al. Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. Intensive Care Med. 2017 Jan;43(1):1-15. Abstract

181. Yatabe T, Inoue S, Sakaguchi M, et al. The optimal target for acute glycemic control in critically ill patients: a network meta-analysis. Intensive Care Med. 2017 Jan;43(1):16-28. Abstract

182. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8.Full text

183. American Diabetes Association Professional Practice Committee. 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(supplement_1):S128-S145.Full text  Abstract

184. Vue MH, Setter SM. Drug-Induced Glucose Alterations Part 1: Drug-Induced Hypoglycemia. Diabetes Spectr 1 August 2011; 24 (3): 171–7.Full text  Abstract

185. Wang C, Fang W, Li Z, et al. Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemia. Front Endocrinol (Lausanne). 2023;14:1059522.Full text  Abstract

186. McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.Full text  Abstract

187. American Diabetes Association Professional Practice Committee. 13. Older Adults: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(supplement_1):S266-S282.Full text  Abstract

188. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication].Full text

189. American Diabetes Association Professional Practice Committee. 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 suppl 1):S252-65.Full text  Abstract

190. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 Jul;34(7):1517-8.Full text  Abstract

191. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012 Mar;2(1):1-138.Full text

192. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2025 [internet publication].Full text

193. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2025 [internet publication].Full text

194. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21. Abstract

195. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51. Abstract

196. Bauer M, Severus E, Köhler S, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders. part 2: maintenance treatment of major depressive disorder-update 2015. World J Biol Psychiatry. 2015 Feb;16(2):76-95. Abstract

197. Hoffelt C, Gross T. A review of significant pharmacokinetic drug interactions with antidepressants and their management. Ment Health Clin. 2016 2016 Mar 8;6(1):35-41.Full text  Abstract

198. Van Leeuwen E, van Driel ML, Horowitz MA, et al. Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults. Cochrane Database Syst Rev. 2021 Apr 15;(4):CD013495.Full text  Abstract

199. Qaseem A, Owens DK, Etxeandia-Ikobaltzeta I, et al. Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder: a living clinical guideline from the American College of Physicians. Ann Intern Med. 2023 Feb;176(2):239-52.Full text  Abstract

200. Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. Am J Kidney Dis. 2008 Jul;52(1):144-53. Abstract

201. Liamis G, Filippatos TD, Elisaf MS. Thiazide-associated hyponatremia in the elderly: what the clinician needs to know. J Geriatr Cardiol. 2016 Feb;13(2):175-82.Full text  Abstract

202. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Abstract

203. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626. Abstract

204. Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013 Winter;13(4):533-40.Full text  Abstract

205. Chander WP, Singh N, Mukhiya GK. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. J Indian Med Assoc. 2011 Jan;109(1):36-7. Abstract

206. Voican CS, Corruble E, Naveau S, et al. Antidepressant-induced liver injury: a review for clinicians. Am J Psychiatry. 2014 Apr;171(4):404-15.Full text  Abstract

207. Saraghi M, Golden LR, Hersh EV. Anesthetic considerations for patients on antidepressant therapy-part I. Anesth Prog. 2017 Winter;64(4):253-61.Full text  Abstract

208. Harbell MW, Dumitrascu C, Bettini L, et al. Anesthetic considerations for patients on psychotropic drug therapies. Neurol Int. 2021 Nov 29;13(4):640-58.Full text  Abstract

209. Tisdale JE, Chung MK, Campbell KB, et al. Drug-induced arrhythmias: a scientific statement from the American Heart Association. Circulation. 2020 Oct 13;142(15):e214-233.Full text  Abstract

210. Siu AL, US Preventive Services Task Force (USPSTF), Bibbins-Domingo K, et al. Screening for depression in adults: US Preventive Services Task Force recommendation statement. JAMA. 2016 Jan 26;315(4):380-7.Full text  Abstract

211. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci. 2007;9(1):47-59.Full text  Abstract

212. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97.Full text  Abstract

213. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40.Full text  Abstract

214. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid J. 2016 Jun;11(6):4-7.Full text

215. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94. Abstract

216. Oliveira P, Ribeiro J, Donato H, et al. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017 Mar 6:16:17.Full text  Abstract

217. US Preventive Services Task Force, Krist AH, Davidson KW, et al. Interventions for tobacco smoking cessation in adults, including pregnant persons: US Preventive Services Task Force recommendation statement. JAMA. 2021 Jan 19;325(3):265-79.Full text  Abstract

218. Fiore MC, Jaén CR, Baker TB, et al. Treating tobacco use and dependence: 2008 update. Clinical practice guideline. Rockville, MD: US Department of Health and Human Services Public Health Service; May 2008 [internet publication].Full text

219. United States Public Health Service Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. Smoking cessation: a report of the Surgeon General. Washington, DC: US Department of Health and Human Services; 2020 [internet publication].Full text  Abstract

220. Streck JM, Rigotti NA, Livingstone-Banks J, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024 May 21;(5):CD001837.Full text  Abstract

221. Theodoulou A, Chepkin SC, Ye W, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;(6):CD013308.Full text  Abstract

222. Rigotti NA, Kruse GR, Livingstone-Banks J, et al. Treatment of tobacco smoking: a review. JAMA. 2022 Feb 8;327(6):566-77. Abstract

223. Agrawal S, Evison M, Ananth S, et al. Medical management of inpatients with tobacco dependency. Thorax. 2024 Mar 26;79(suppl 1):3-11. Abstract

224. Thomas KH, Dalili MN, López-López JA, et al. Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials. Addiction. 2022 Apr;117(4):861-76.Full text  Abstract

225. Livingstone-Banks J, Fanshawe TR, Thomas KH, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 28;(6):CD006103.Full text

226. Perret J, Yip SWS, Idrose NS, et al. Undiagnosed and 'overdiagnosed' COPD using postbronchodilator spirometry in primary healthcare settings: a systematic review and meta-analysis. BMJ Open Respir Res. 2023 Apr;10(1):e001478.Full text  Abstract

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