Prognosis

The prognosis for patients with OI depends on the severity of their condition (depending on the type of OI and underlying genetic variant) and the treatment given. Physical health-related quality of life is lower in individuals with OI as compared with the reference population.[92][93]

People with the more severe forms of OI have significantly lower physical health-related quality of life compared with those who have mild OI (such as type I). People with OI type I typically have a normal life span, whereas those with severe types of OI have increased mortality and morbidity.[11] Infants with type II OI may be stillborn or die within the first few months of life.[42] In a population and register-based cohort study conducted in Denmark, the all-cause mortality hazard ratio between individuals with OI and the reference population was 2.90.[44] The median survival time for males with OI was 72.4 years, versus 81.9 years in the reference population. The median survival time for females with OI was 77.4 years, compared with 84.5 years in the reference population.[44]

Patients with OI have a higher risk of death from respiratory diseases and trauma.[11][44][45][46][47][48] However, keep in mind that the natural history of this condition is dynamic, and can be modified by the repurposing of current therapies and emergence of new therapies, as well as by the increasing awareness of healthcare providers and lay communities involved in the care and support of patients with OI, respectively.

Use of this content is subject to our disclaimer