Emerging treatments

Intranasal capsaicin

Intranasal capsaicin, a TRPV1 (transient receptor potential vanilloid subfamily, member 1) agonist, has been found to be effective in the treatment of NAR or patients with a significant component of NAR.[43] This suggests a role for TRP receptors in this disorder.[12][44] A Cochrane review concluded that capsaicin is a reasonable option to try under physician supervision, particularly as there are so few options in non-allergic rhinitis.[43] When given under physician supervision, capsaicin is administered under local anesthesia, as the concentration of capsaicin used causes a great deal of irritation.[12] Homeopathic preparations are also available, which include capsaicin and also other ingredients such as eucalyptus and menthol, both of which can also activate TRP receptors. Since they are available in nasal sprays, these can be used by patients without direct supervision, but they are not considered true capsaicin, due to the additional ingredients.

Botulinum toxin

Botulinum toxin type A is a potential treatment option for chronic rhinitis patients who are resistant to other treatments.[45]​​[46]

Controversial therapies

Currently unproven treatment modalities for non-allergic rhinitis include radiofrequency stimulation and kinetic oscillation stimulation.[47][48][49][50]​​

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