Close monitoring and treatment is essential. An inpatient follow-up should be arranged within the first 1 to 2 weeks of discharge. Monthly visits should be scheduled thereafter. Lipids should be monitored at least every 6 months until a target low-density lipoprotein <70 mg/dL is reached in patients who have had a myocardial infarction or have coronary artery disease. The need for follow-up cardiac ultrasounds is at the discretion of the physician. However, cardiac ultrasounds are necessary to evaluate and monitor ventricular function.[2]Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-228.
http://www.onlinejacc.org/content/64/24/e139
http://www.ncbi.nlm.nih.gov/pubmed/25260718?tool=bestpractice.com
It is crucial to assist smoking cessation efforts and promote a physical activity regimen. If available, cardiac rehabilitation is extremely helpful. Psychosocial risk factors such as anxiety and depression should be addressed. Depression in particular has been associated with a poor prognosis.[46]Lichtman JH, Froelicher ES, Blumenthal JA, et al; American Heart Association Statistics Committee of the Council on Epidemiology and Prevention and the Council on Cardiovascular and Stroke Nursing. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation. 2014 Mar 25;129(12):1350-69.
https://www.ahajournals.org/doi/full/10.1161/cir.0000000000000019
http://www.ncbi.nlm.nih.gov/pubmed/24566200?tool=bestpractice.com
All medications should be reviewed at every follow-up visit to encourage patient compliance and optimal dosing.[2]Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-228.
http://www.onlinejacc.org/content/64/24/e139
http://www.ncbi.nlm.nih.gov/pubmed/25260718?tool=bestpractice.com
In patients who have undergone direct reperfusion, further noninvasive stress testing or further imaging is indicated only if stenosis of intermediate severity (luminal narrowing of 50% to 70%) is present in a nonculprit artery. Patients with recurrent ischemic-type pain after reperfusion may need angiography after medical therapy to evaluate for further stenosis or occlusion.[64]Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee On Clinical Practice Guidelines. Circulation. 2022 Jan 18;145(3):e18-114.
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001038
http://www.ncbi.nlm.nih.gov/pubmed/34882435?tool=bestpractice.com
All patients, regardless of whether a stent was placed, should be treated with a P2Y12 inhibitor for up to 12 months and low-dose aspirin daily as long as tolerated. There is some evidence that patients treated with bare metal stents (BMS) are at an increased risk for repeat procedural care compared to those treated with drug-eluting stents (DES). P2Y12 inhibitors for patients with acute coronary syndrome NSTEMI should be continued for at least 12 months in all patients despite treatment strategy of medical management, balloon angioplasty, lytic therapy, BMS placement, or DES placement. For selected patients with stable coronary artery disease receiving percutaneous coronary intervention, shorter duration (1-3 months) of dual antiplatelet therapies may be considered with subsequent transition to P2Y12 inhibitor monotherapy to reduce the risk of bleeding events.[64]Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee On Clinical Practice Guidelines. Circulation. 2022 Jan 18;145(3):e18-114.
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001038
http://www.ncbi.nlm.nih.gov/pubmed/34882435?tool=bestpractice.com
[153]Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease. J Am Coll Cardiol. 2016 Sep 6;68(10):1082-115.
http://www.onlinejacc.org/content/68/10/1082
http://www.ncbi.nlm.nih.gov/pubmed/27036918?tool=bestpractice.com
A scientific advisory from several major health organizations describes the risks of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents.[138]Grines CL, Bonow RO, Casey DE Jr, et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents. Circulation. 2007 Feb 13;115(6):813-8.
https://www.ahajournals.org/doi/full/10.1161/circulationaha.106.180944
http://www.ncbi.nlm.nih.gov/pubmed/17224480?tool=bestpractice.com