The natural course involves slow and steady growth. With progressive aneurysm enlargement, the risk of AAA rupture increases.[3]Wanhainen A, Van Herzeele I, Bastos Goncalves F, et al. Editor's choice -- European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg. 2024 Feb;67(2):192-331.
https://www.ejves.com/article/S1078-5884(23)00889-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38307694?tool=bestpractice.com
Most patients with rupture will not survive to reach the operating suite; mortality from ruptured abdominal aortic aneurysms is estimated to be 80% to 90%.[5]Isselbacher EM, Preventza O, Hamilton Black J 3rd, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022 Dec 13;146(24):e334-e482.
https://www.doi.org/10.1161/CIR.0000000000001106
http://www.ncbi.nlm.nih.gov/pubmed/36322642?tool=bestpractice.com
Given the morbidity and mortality associated with surgical intervention, repair is typically deferred until the theoretical risk of rupture exceeds the estimated risk of operative mortality. The majority of patients undergoing open repair remain without significant graft-related complications during the remainder of their lives (0.4% to 2.3% incidence of late graft-related complications).[265]Hertzer NR, Mascha EJ, Karafa MT, et al. Open infrarenal abdominal aortic aneurysm repair: the Cleveland Clinic experience from 1989 to 1998. J Vasc Surg. 2002 Jun;35(6):1145-54.
http://www.ncbi.nlm.nih.gov/pubmed/12042724?tool=bestpractice.com
Five-year survival rates after intact aneurysm repair average 60% to 75%. Those undergoing endovascular aneurysm repair (EVAR) are more likely to have a delayed complication and require re-intervention and late survival may be worse in patients undergoing EVAR for intact AAA.[167]Galanakis N, Kontopodis N, Tavlas E, et al. Does a previous aortic endograft confer any protective effect during abdominal aortic aneurysm rupture? Systematic review and meta-analysis of comparative studies. Vascular. 2020 Jun;28(3):241-50.
http://www.ncbi.nlm.nih.gov/pubmed/31937207?tool=bestpractice.com
[168]Wanken ZJ, Barnes JA, Trooboff SW, et al. A systematic review and meta-analysis of long-term reintervention after endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2020 Sep;72(3):1122-31.
https://www.doi.org/10.1016/j.jvs.2020.02.030
http://www.ncbi.nlm.nih.gov/pubmed/32273226?tool=bestpractice.com
[175]Takagi H, Ando T, Umemoto T, et al. Worse late-phase survival after elective endovascular than open surgical repair for intact abdominal aortic aneurysm. Int J Cardiol. 2017 Jun 1;236:427-31.
http://www.ncbi.nlm.nih.gov/pubmed/28096046?tool=bestpractice.com
Other risk factors for poor outcome include skeletal muscle mass; there is a significant link between low skeletal muscle mass and morbidity following AAA repair.[266]Antoniou GA, Rojoa D, Antoniou SA, et al. Effect of low skeletal muscle mass on post-operative survival of patients with abdominal aortic aneurysm: a prognostic factor review and meta-analysis of time-to-event data. Eur J Vasc Endovasc Surg. 2019 Aug;58(2):190-8.
https://www.doi.org/10.1016/j.ejvs.2019.03.020
http://www.ncbi.nlm.nih.gov/pubmed/31204184?tool=bestpractice.com
In elderly patients there is an early deterioration in postoperative quality of life, with a delay to mental health recovery of about 4 to 6 weeks, and to physical health recovery of 1 to 3 months, regardless of operative technique. However, quality of life does return to baseline and is maintained in the long term, supporting surgical intervention for AAA in elderly patients.[267]Shan L, Saxena A, Goh D, et al. A systematic review on the quality of life and functional status after abdominal aortic aneurysm repair in elderly patients with an average age older than 75 years. J Vasc Surg. 2019 Apr;69(4):1268-1281.
https://www.doi.org/10.1016/j.jvs.2018.09.032
http://www.ncbi.nlm.nih.gov/pubmed/30578073?tool=bestpractice.com