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Last reviewed: 21 Apr 2025
Last updated: 20 May 2025

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • wheezing episode triggers
  • increased work of breathing
  • features of atopic disease
  • history of response to treatment within appropriate time frame

Other diagnostic factors

  • age >3 years
  • dry night-time cough
  • dyspnoea on exertion
  • expiratory wheezing
  • chest wall deformity

Risk factors

  • allergic sensitisation
  • atopic disease
  • respiratory tract infections in early life
  • serum eosinophilia
  • family history of asthma or atopy
  • gene polymorphisms and epigenetics
  • passive or active cigarette smoking
  • vaping
  • maternal smoking in pregnancy
  • abnormal lung function and airway hyper-responsiveness
  • indoor and outdoor air pollution
  • low socio-economic status
  • pesticide exposure
  • male sex
  • obesity
  • gastro-oesophageal reflux disease (GORD)
  • obstructive sleep apnoea (OSA)
  • assisted reproductive technologies
  • cesarean section
  • intestinal microbiota
  • acid-suppressive drug use in pregnancy and childhood
  • paracetamol use in pregnancy
  • antibiotic use in pregnancy

Diagnostic investigations

1st investigations to order

  • spirometry
  • peak expiratory flow (PEF)
  • response to bronchodilator

Investigations to consider

  • fractional expired nitric oxide (FeNO)
  • airway challenge tests
  • exercise challenge test
  • FBC
  • sweat test
  • sputum culture
  • skin prick testing
  • chest x-ray
  • electron micrograph ciliary studies
  • chest CT
  • sinus CT
  • bronchoscopy

Emerging tests

  • bronchoalveolar lavage

Treatment algorithm

Contributors

Authors

Paul D. Robinson, MBChB, MRCPCH, FRACP, PhD, ATSF

Respiratory and Sleep Physician

Queensland Children's Hospital

Conjoint Professor

Child Health Research Centre

University of Queensland

Brisbane

Queensland

Australia

Disclosures

PDR declares that he has no competing interests.

Anne Chang, MBBS, FRACP, MPHTM, PhD, FAPSR, FThorSoc, FAHMS

Professor

Respiratory and Sleep Physician

Queensland Children's Hospital

Queensland University of Technology

Brisbane

Menzies School of Health Research

Charles Darwin University

Darwin

Australia

Disclosures

AC is an author of a number of references cited in this topic.

Peer reviewers

Kenan Haver, MD

Associate Professor of Pediatrics, Harvard Medical School

Boston Children's Hospital

Division of Pulmonary Medicine

Boston

MA

Disclosures

KH receives royalties from UpToDate.

Peter Griffiths, MBChB

General Practitioner

Harborne Medical Practice

Birmingham

UK

Disclosures

PG declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Global Initiative for Asthma. 2024 Global strategy for asthma management and prevention. May 2024 [internet publication].Full text

National Institute for Health and Care Excellence. Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN). Nov 2024 [internet publication].Full text

National Institute for Health and Care Excellence. Asthma pathway (BTS, NICE, SIGN). Nov 2024 [internet publication].Full text

National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program. Guidelines for the diagnosis and management of asthma. Aug 2007 [internet publication].Full text

Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC), Cloutier MM, Baptist AP, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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