Acute conjunctivitis
- Overview
- Theory
- Diagnosis
- Management
- Follow up
- Resources
Treatment algorithm
Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer
allergic conjunctivitis (seasonal/perennial)
supportive measures
Mild allergic conjunctivitis refers to itchy, watery, red eyes occurring seasonally and responding to supportive measures, including artificial tears and cool compresses.
Artificial tears help to dilute various allergens and inflammatory mediators that may be present on the ocular surface. Patients can also wear sunglasses as a barrier against allergens, avoid rubbing their eyes, and avoid known allergens. Hypoallergenic bedding, eyelid cleansers, bathing/showering before bedtime, and frequent washing of clothes may also be helpful.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
mast cell stabiliser ± antihistamine
Moderate allergic conjunctivitis refers to itchy, watery, red eyes that usually occur seasonally and respond to topical antihistamines (e.g., alcaftadine, pheniramine) and/or mast cell stabilisers (e.g., sodium cromoglicate, lodoxamide).[63]Castillo M, Scott NW, Mustafa MZ, et al. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Cochrane Database Syst Rev. 2015 Jun 1;(6):CD009566. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009566.pub2/full http://www.ncbi.nlm.nih.gov/pubmed/26028608?tool=bestpractice.com [102]Mahvan TD, Buckley WA, Hornecker JR. Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1025-32. http://www.ncbi.nlm.nih.gov/pubmed/22811343?tool=bestpractice.com [103]Marini MC, Berra ML, Girado F, et al. Efficacy and toxicity evaluation of bepotastine besilate 1.5% preservative-free eye drops vs olopatadine hydrochloride 0.2% bak-preserved eye drops in patients with allergic conjunctivitis. Clin Ophthalmol. 2023;17:3477-89. https://pmc.ncbi.nlm.nih.gov/articles/PMC10658941 http://www.ncbi.nlm.nih.gov/pubmed/38026598?tool=bestpractice.com
Vasoconstrictors (such as naphazoline) are present in some topical antihistamine preparations for additional short-term relief of vascular injection.
Drugs with both antihistamine and mast cell stabilising activity include azelastine, bepotastine, epinastine, olopatadine, and ketotifen.[67]Abelson MB, Gomes PJ. Olopatadine 0.2% ophthalmic solution: the first ophthalmic antiallergy agent with once-daily dosing. Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):453-61. http://www.ncbi.nlm.nih.gov/pubmed/18433347?tool=bestpractice.com [68]Gonzalez-Estrada A, Reddy K, Dimov V, et al. Olopatadine hydrochloride ophthalmic solution for the treatment of allergic conjunctivitis. Expert Opin Pharmacother. 2017 Aug;18(11):1137-43. http://www.ncbi.nlm.nih.gov/pubmed/28656804?tool=bestpractice.com [69]Kam KW, Chen LJ, Wat N, et al. Topical olopatadine in the treatment of allergic conjunctivitis: a systematic review and meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-77. http://www.ncbi.nlm.nih.gov/pubmed/27192186?tool=bestpractice.com
Oral antihistamines, which are longer-acting, may be used with, or instead of, topical antihistamines. The newer-generation oral antihistamines are preferred because they are less sedating. These include fexofenadine, loratadine, and cetirizine.
Although commonly used, oral antihistamines may lead to or worsen dry eye syndrome, and impair the tear film, and so worsen allergic conjunctivitis. Simultaneous use of artificial tears may improve tear deficiency and dilute allergens and inflammatory mediators on the eye's surface.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
Primary options
sodium cromoglicate ophthalmic: (2%) 1-2 drops into the affected eye(s) every 4-6 hours
or
lodoxamide ophthalmic: (0.1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
-- AND / OR --
alcaftadine ophthalmic: (0.25%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
or
naphazoline/pheniramine ophthalmic: (0.025%/0.3%) children ≥6 years of age and adults: 1-2 drops into the affected eye(s) up to four times daily
or
azelastine ophthalmic: (0.05%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
or
bepotastine ophthalmic: (1.5%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
or
epinastine ophthalmic: (0.05%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
or
olopatadine ophthalmic: (0.1%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily; (0.2%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
or
ketotifen ophthalmic: (0.025%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
-- AND / OR --
cetirizine: children 6-11 months of age: 2.5 mg orally once daily when required; children 1-5 years of age: 2.5 to 5 mg/day orally when required given in 1-2 divided doses; children ≥6 years of age and adults: 5-10 mg orally once daily when required
or
loratadine: children 2-5 years of age: 5 mg orally once daily when required; children ≥6 years of age and adults: 10 mg orally once daily when required
or
fexofenadine: children 2-11 years of age: 30 mg orally twice daily when required; children ≥12 years of age and adults: 180 mg orally once daily or 60 mg twice daily when required
supportive measures
Treatment recommended for ALL patients in selected patient group
Supportive measures include artificial tears and cool compresses. Artificial tears help to dilute various allergens and inflammatory mediators that may be present on the ocular surface. Patients can also wear sunglasses as a barrier against allergens, avoid rubbing their eyes, and avoid known allergens. Hypoallergenic bedding, eyelid cleansers, bathing/showering before bedtime, and frequent washing of clothes may also be helpful.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
topical non-steroidal anti-inflammatory drug
Additional treatment recommended for SOME patients in selected patient group
Topical non-steroidal anti-inflammatory drugs, such as ketorolac, diclofenac, bromfenac, and nepafenac, can be added if further anti-inflammatory effect is required.
Primary options
ketorolac ophthalmic: (0.5%) children ≥2 years of age and adults: 1 drop into the affected eye(s) four times daily
OR
nepafenac ophthalmic: (0.1%) children ≥10 years of age and adults: 1 drop into the affected eye(s) three times daily; (0.3%) children ≥10 years of age and adults: 1 drop into the affected eye(s) once daily
OR
diclofenac ophthalmic: (0.1%) adults: 1 drop into the affected eye(s) four times daily
OR
bromfenac ophthalmic: (0.09%) adults: 1 drop into the affected eye(s) once or twice daily (depending on formulation)
mast cell stabiliser ± antihistamine
Severe allergic disease is regarded as the presence of symptoms year round and is associated with greater inflammation than moderate disease.
Use topical mast cell stabilisers (e.g., sodium cromoglicate, lodoxamide) and/or topical antihistamines (e.g., alcaftadine, pheniramine) in addition to a topical corticosteroid, or ciclosporin.[63]Castillo M, Scott NW, Mustafa MZ, et al. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Cochrane Database Syst Rev. 2015 Jun 1;(6):CD009566. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009566.pub2/full http://www.ncbi.nlm.nih.gov/pubmed/26028608?tool=bestpractice.com [102]Mahvan TD, Buckley WA, Hornecker JR. Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1025-32. http://www.ncbi.nlm.nih.gov/pubmed/22811343?tool=bestpractice.com [103]Marini MC, Berra ML, Girado F, et al. Efficacy and toxicity evaluation of bepotastine besilate 1.5% preservative-free eye drops vs olopatadine hydrochloride 0.2% bak-preserved eye drops in patients with allergic conjunctivitis. Clin Ophthalmol. 2023;17:3477-89. https://pmc.ncbi.nlm.nih.gov/articles/PMC10658941 http://www.ncbi.nlm.nih.gov/pubmed/38026598?tool=bestpractice.com
Vasoconstrictors (such as naphazoline) are present in some topical antihistamine preparations for additional short-term relief of vascular injection.
Drugs with both antihistamine and mast cell stabilising activity include azelastine, bepotastine, epinastine, olopatadine, and ketotifen.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [67]Abelson MB, Gomes PJ. Olopatadine 0.2% ophthalmic solution: the first ophthalmic antiallergy agent with once-daily dosing. Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):453-61. http://www.ncbi.nlm.nih.gov/pubmed/18433347?tool=bestpractice.com [68]Gonzalez-Estrada A, Reddy K, Dimov V, et al. Olopatadine hydrochloride ophthalmic solution for the treatment of allergic conjunctivitis. Expert Opin Pharmacother. 2017 Aug;18(11):1137-43. http://www.ncbi.nlm.nih.gov/pubmed/28656804?tool=bestpractice.com [69]Kam KW, Chen LJ, Wat N, et al. Topical olopatadine in the treatment of allergic conjunctivitis: a systematic review and meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-77. http://www.ncbi.nlm.nih.gov/pubmed/27192186?tool=bestpractice.com
Oral antihistamines, which are longer-acting, may be used with, or instead of, topical antihistamines. The newer-generation oral antihistamines are preferred because they are less sedating. These include fexofenadine, loratadine, and cetirizine.
Although commonly used, oral antihistamines may lead to or worsen dry eye syndrome, and impair the tear film, and so worsen allergic conjunctivitis. Simultaneous use of artificial tears may improve tear deficiency and dilute allergens and inflammatory mediators on the eye's surface.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [33]Amescua G, Ahmad S, Cheung AY, et al. Dry eye syndrome preferred practice pattern®. Ophthalmology. 2024 Apr;131(4):P1-49. https://www.aao.org/education/preferred-practice-pattern/dry-eye-syndrome-ppp-2023 http://www.ncbi.nlm.nih.gov/pubmed/38349301?tool=bestpractice.com
Primary options
sodium cromoglicate ophthalmic: (2%) 1-2 drops into the affected eye(s) every 4-6 hours
or
lodoxamide ophthalmic: (0.1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
-- AND / OR --
alcaftadine ophthalmic: (0.25%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
or
naphazoline/pheniramine ophthalmic: (0.025%/0.3%) children ≥6 years of age and adults: 1-2 drops into the affected eye(s) up to four times daily
or
azelastine ophthalmic: (0.05%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
or
bepotastine ophthalmic: (1.5%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
or
epinastine ophthalmic: (0.05%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
or
olopatadine ophthalmic: (0.1%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily; (0.2%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
or
ketotifen ophthalmic: (0.025%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
-- AND / OR --
cetirizine: children 6-11 months of age: 2.5 mg orally once daily when required; children 1-5 years of age: 2.5 to 5 mg/day orally when required given in 1-2 divided doses; children ≥6 years of age and adults: 5-10 mg orally once daily when required
or
loratadine: children 2-5 years of age: 5 mg orally once daily when required; children ≥6 years of age and adults: 10 mg orally once daily when required
or
fexofenadine: children 2-11 years of age: 30 mg orally twice daily when required; children ≥12 years of age and adults: 180 mg orally once daily or 60 mg twice daily when required
topical corticosteroid or ciclosporin
Treatment recommended for ALL patients in selected patient group
Severe or resistant allergic disease may require additional treatment with a brief course (1 to 2 weeks) of topical corticosteroids.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [73]Gong L, Sun X, Qu J, et al. Loteprednol etabonate suspension 0.2% administered QID compared with olopatadine solution 0.1% administered BID in the treatment of seasonal allergic conjunctivitis: a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Clin Ther. 2012 Jun;34(6):1259-72. http://www.ncbi.nlm.nih.gov/pubmed/22627057?tool=bestpractice.com This treatment can be used together with topical or oral antihistamines and mast cell stabilisers. Consider referral to a consultant eye physician. Only ophthalmic clinicians should prescribe topical corticosteroids.
Topical ciclosporin provides relief with corticosteroid-sparing effects. It can be considered second line instead of corticosteroids for ocular dryness and inflammation in severe allergic conjunctivitis. It may also be particularly effective as a second-line treatment for severe atopic or vernal conjunctivitis.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [8]Ono SJ, Abelson MB. Allergic conjunctivitis: update on pathophysiology and prospects for future treatment. J Allergy Clin Immunol. 2005 Jan;115(1):118-22. http://www.ncbi.nlm.nih.gov/pubmed/15637556?tool=bestpractice.com [9]Buckley RJ. Allergic eye disease: a clinical challenge. Clin Exp Allergy. 1998 Dec;28 Suppl 6:39-43. http://www.ncbi.nlm.nih.gov/pubmed/9988434?tool=bestpractice.com [13]Bruschi G, Ghiglioni DG, Cozzi L, et al. Vernal keratoconjunctivitis: a systematic review. Clin Rev Allergy Immunol. 2023 Aug;65(2):277-329. https://pmc.ncbi.nlm.nih.gov/articles/PMC10567967 http://www.ncbi.nlm.nih.gov/pubmed/37658939?tool=bestpractice.com [77]Mantelli F, Santos MS, Petitti T, et al. Systematic review and meta-analysis of randomised clinical trials on topical treatments for vernal keratoconjunctivitis. Br J Ophthalmol. 2007 Dec;91(12):1656-61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095503 http://www.ncbi.nlm.nih.gov/pubmed/17588996?tool=bestpractice.com [78]Swamy BN, Chilov M, McClellan K, et al. Topical non-steroidal anti-inflammatory drugs in allergic conjunctivitis: meta-analysis of randomized trial data. Ophthalmic Epidemiol. 2007 Sep-Oct;14(5):311-9. http://www.ncbi.nlm.nih.gov/pubmed/17994441?tool=bestpractice.com [79]Takamura E, Uchio E, Ebihara N, et al; Japanese Society of Allergology. Japanese guidelines for allergic conjunctival diseases 2017. Allergol Int. 2017 Apr;66(2):220-9. https://www.sciencedirect.com/science/article/pii/S1323893016301733?via%3Dihub http://www.ncbi.nlm.nih.gov/pubmed/28209324?tool=bestpractice.com [80]Berger WE, Granet DB, Kabat AG. Diagnosis and management of allergic conjunctivitis in pediatric patients. Allergy Asthma Proc. 2017 Jan 1;38(1):16-27. http://www.ncbi.nlm.nih.gov/pubmed/28052798?tool=bestpractice.com
Primary options
loteprednol ophthalmic: (0.5%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
OR
prednisolone ophthalmic: (1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) two to four times daily
Secondary options
ciclosporin ophthalmic: (0.05% or 0.09% or 0.01% solution) adults: 1 drop into the affected eye(s) twice daily
supportive measures
Treatment recommended for ALL patients in selected patient group
Supportive measures include artificial tears and cool compresses. Artificial tears help to dilute various allergens and inflammatory mediators that may be present on the ocular surface. Patients can also wear sunglasses as a barrier against allergens, avoid rubbing their eyes, and avoid known allergens. Hypoallergenic bedding, eyelid cleansers, bathing/showering before bedtime, and frequent washing of clothes may also be helpful.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
topical non-steroidal anti-inflammatory drug
Additional treatment recommended for SOME patients in selected patient group
Topical non-steroidal anti-inflammatory drugs, such as ketorolac, diclofenac, bromfenac, and nepafenac, can be added if necessary if further anti-inflammatory effect is required.
Primary options
ketorolac ophthalmic: (0.5%) children ≥2 years of age and adults: 1 drop into the affected eye(s) four times daily
OR
nepafenac ophthalmic: (0.1%) children ≥10 years of age and adults: 1 drop into the affected eye(s) three times daily; (0.3%) children ≥10 years of age and adults: 1 drop into the affected eye(s) once daily
OR
diclofenac ophthalmic: (0.1%) adults: 1 drop into the affected eye(s) four times daily
OR
bromfenac ophthalmic: (0.09%) adults: 1 drop into the affected eye(s) once or twice daily (depending on formulation)
allergen-specific immunotherapy
Additional treatment recommended for SOME patients in selected patient group
Allergen-specific immunotherapy may be an option for patients who have disease that cannot be controlled by topical medications and oral antihistamines.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
bacterial conjunctivitis
consider topical broad-spectrum antibiotics
Mild bacterial conjunctivitis is usually self-limiting and may not require antibiotic therapy.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204.
https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
However, compared with placebo, antibiotics are associated with modestly improved resolution of symptoms or signs by days 4 to 9.[81]Chen YY, Liu SH, Nurmatov U, et al. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD001211.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001211.pub4/full
http://www.ncbi.nlm.nih.gov/pubmed/36912752?tool=bestpractice.com
[82]Rose P. Management strategies for acute infective conjunctivitis in primary care: a systematic review. Expert Opin Pharmacother. 2007 Aug;8(12):1903-21.
http://www.ncbi.nlm.nih.gov/pubmed/17696792?tool=bestpractice.com
[ ]
For people with acute bacterial conjunctivitis, what are the effects of topic antibiotics?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.4307/fullShow me the answer
Consider broad-spectrum topical antibiotics such as erythromycin, azithromycin, or polymyxin/trimethoprim as a first-line therapy.[81]Chen YY, Liu SH, Nurmatov U, et al. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD001211. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001211.pub4/full http://www.ncbi.nlm.nih.gov/pubmed/36912752?tool=bestpractice.com [85]Denis F, Chaumeil C, Goldschmidt P, et al. Microbiological efficacy of 3-day treatment with azithromycin 1.5% eye-drops for purulent bacterial conjunctivitis. Eur J Ophthalmol. 2008 Nov-Dec;18(6):858-68. http://www.ncbi.nlm.nih.gov/pubmed/18988154?tool=bestpractice.com [86]Abelson MB, Heller W, Shapiro AM, et al; AzaSite Clinical Study Group. Clinical cure of bacterial conjunctivitis with azithromycin 1%: vehicle-controlled, double-masked clinical trial. Am J Ophthalmol. 2008 Jun;145(6):959-65. http://www.ncbi.nlm.nih.gov/pubmed/18374301?tool=bestpractice.com [87]Protzko E, Bowman L, Abelson M, et al; AzaSite Clinical Study Group. Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3425-9. https://iovs.arvojournals.org/article.aspx?articleid=2184229 http://www.ncbi.nlm.nih.gov/pubmed/17652708?tool=bestpractice.com
Alternatives include bacitracin, polymyxin/bacitracin, or sulfacetamide.[81]Chen YY, Liu SH, Nurmatov U, et al. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD001211. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001211.pub4/full http://www.ncbi.nlm.nih.gov/pubmed/36912752?tool=bestpractice.com
Antibiotics should be continued for 7 to 10 days.
Primary options
azithromycin ophthalmic: (1%) children ≥1 year of age and adults: 1 drop into the affected eye(s) twice daily for 2 days, then once daily for 5 days
OR
erythromycin ophthalmic: (0.5%) children and adults: apply to the affected eye(s) up to six times daily
OR
polymyxin B/trimethoprim ophthalmic: (10,000 units/mL; 1 mg/mL) children ≥2 months of age and adults: 1 drop into the affected eye(s) every 3 hours up to six times daily
Secondary options
bacitracin ophthalmic: (500 units/g) children and adults: apply to the affected eye(s) every 3-4 hours
OR
sulfacetamide ophthalmic: (10% solution) children ≥2 months of age and adults: 1-2 drops into the affected eye(s) every 2-3 hours; (10% ointment) children ≥2 months of age and adults: apply to the affected eye(s) every 3-4 hours and at bedtime
OR
bacitracin/ polymyxin B ophthalmic: (500 units/g; 10,000 units/g) children and adults: apply to the affected eye(s) every 3-4 hours
topical fluoroquinolone
Consider topical fluoroquinolones for more severe bacterial eye infections. They can also be used if bacterial resistance to other antibacterials is known. Immunocompromised patients should be started on a topical fluoroquinolone as a first-line therapy.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [83]Sheikh A, Hurwitz B. Topical antibiotics for acute bacterial conjunctivitis: a systematic review. Br J Gen Pract. 2001 Jun;51(467):473-7. http://www.ncbi.nlm.nih.gov/pubmed/11407054?tool=bestpractice.com [88]Mah F. Bacterial conjunctivitis in pediatrics and primary care. Pediatr Clin North Am. 2006 May;53 Suppl 1:7-10; quiz 11, 13-5. http://www.ncbi.nlm.nih.gov/pubmed/16898650?tool=bestpractice.com [89]Alfonso E, Crider J. Ophthalmic infections and their anti-infective challenges. Surv Ophthalmol. 2005 Nov;50 Suppl 1:S1-6. http://www.ncbi.nlm.nih.gov/pubmed/16257307?tool=bestpractice.com [94]Sanfilippo CM, Allaire CM, DeCory HH. Besifloxacin ophthalmic suspension 0.6% compared with gatifloxacin ophthalmic solution 0.3% for the treatment of bacterial conjunctivitis in neonates. Drugs R D. 2017 Mar;17(1):167-75. https://link.springer.com/article/10.1007%2Fs40268-016-0164-6 http://www.ncbi.nlm.nih.gov/pubmed/28078599?tool=bestpractice.com [95]O'Brien TP. Besifloxacin ophthalmic suspension, 0.6%: a novel topical fluoroquinolone for bacterial conjunctivitis. Adv Ther. 2012 Jun;29(6):473-90. http://www.ncbi.nlm.nih.gov/pubmed/22729919?tool=bestpractice.com
Antibiotics should be continued for 7 days.
Primary options
besifloxacin ophthalmic: (0.6%) children ≥1 year of age and adults: 1 drop into the affected eye(s) three times daily
OR
ofloxacin ophthalmic: (0.3%) children ≥1 year of age and adults: 1-2 drops into the affected eye(s) every 2-4 hours for 2 days, then four times daily
OR
ciprofloxacin ophthalmic: (0.3%) children and adults: 1 drop into the affected eye(s) every 2 hours for 2 days, then every 4 hours
OR
levofloxacin ophthalmic: (0.5%) children ≥6 years of age and adults: 1-2 drops into the affected eye(s) every 2 hours up to eight times daily for 2 days, then every 4 hours up to four times daily
OR
moxifloxacin ophthalmic: (0.5%) children and adults: 1 drop into the affected eye(s) three times daily
OR
gatifloxacin ophthalmic: (0.5%) children ≥1 year of age and adults: 1 drop into the affected eye(s) every 2 hours up to eight times daily for 1 day, then two to four times daily
topical plus systemic antibiotics
Hyperacute bacterial conjunctivitis is likely to be caused by Neisseria gonorrhoeae.
Requires systemic treatment with single-dose ceftriaxone and simultaneous treatment for chlamydial co-infection with oral doxycycline or azithromycin.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [96]Haimovici R, Roussel TJ. Treatment of gonococcal conjunctivitis with single-dose intramuscular ceftriaxone. Am J Ophthalmol. 1989 May 15;107(5):511-4. http://www.ncbi.nlm.nih.gov/pubmed/2496606?tool=bestpractice.com
Topical treatment with bacitracin or ciprofloxacin is usually used in conjunction with oral therapy.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
Please refer to our topic on gonorrhoea infection for drug regimens.
chlamydial conjunctivitis (inclusion)
topical plus systemic antibiotics
Chlamydial conjunctivitis that occurs in developed countries is also known as 'inclusion conjunctivitis'. It is caused by Chlamydia trachomatis serotypes D to K and is transmitted sexually. Chlamydial conjunctivitis caused by C trachomatis serotypes A, B, and C is known as trachoma and is mainly limited to areas without adequate access to clean water and sanitation.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext For more information on trachoma, please see Trachoma.
Chlamydial conjunctivitis requires treatment with oral antibiotics. Topical antibiotics are also usually used.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
Primary options
azithromycin: children <45 kg: 20 mg/kg orally as a single dose, maximum 1 g/dose; children >45 kg and adults: 1 g orally as a single dose
or
doxycycline: children ≥8 years of age and adults: 100 mg orally twice daily for 7 days
-- AND --
azithromycin ophthalmic: (1%) children ≥1 year of age and adults: 1 drop into the affected eye(s) twice daily for 2 days, then once daily for 5 days
or
erythromycin ophthalmic: (0.5%) children and adults: apply to the affected eye(s) up to six times daily
viral conjunctivitis
topical antihistamine
Symptomatic relief of itching can be achieved by using topical antihistamines.
Primary options
alcaftadine ophthalmic: (0.25%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
OR
naphazoline/pheniramine ophthalmic: (0.025%/0.3%) children ≥6 years of age and adults: 1-2 drops into the affected eye(s) up to four times daily
OR
azelastine ophthalmic: (0.05%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
OR
bepotastine ophthalmic: (1.5%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
OR
epinastine ophthalmic: (0.05%) children ≥2 years of age and adults: 1 drop into the affected eye(s) twice daily
OR
olopatadine ophthalmic: (0.1%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily; (0.2%) children ≥2 years of age and adults: 1 drop into the affected eye(s) once daily
OR
ketotifen ophthalmic: (0.025%) children ≥3 years of age and adults: 1 drop into the affected eye(s) twice daily
supportive measures
Treatment recommended for ALL patients in selected patient group
Supportive measures include artificial tears and cool compresses.
A cool, damp towel can be placed over the eye area for symptomatic relief.
Oral analgesics may also provide relief.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
topical corticosteroid
Additional treatment recommended for SOME patients in selected patient group
Adenoviral conjunctivitis associated with the presence of a pseudomembrane or corneal subepithelial infiltrates requires treatment with topical corticosteroids. Only ophthalmic clinicians should prescribe topical corticosteroids.
Long-term ocular risks from corticosteroids include delayed wound healing, secondary infection, elevated intraocular pressure, and formation of cataract; loteprednol has fewer adverse effects than prednisolone.
Primary options
loteprednol ophthalmic: (0.5%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
OR
prednisolone ophthalmic: (1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) two to four times daily
topical ganciclovir
Additional treatment recommended for SOME patients in selected patient group
Topical ganciclovir may be considered for confirmed adenovirus, although this use is off label.[97]Kaufman HE. Ganciclovir: a promising topical antiviral gel for herpetic keratitis. Expert Rev Ophthal. 2009;4(4):367-75. https://www.tandfonline.com/doi/abs/10.1586/eop.09.25?journalCode=ierl20 [98]Colin J. Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes. Clin Ophthalmol. 2007 Dec;1(4):441-53. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704535 http://www.ncbi.nlm.nih.gov/pubmed/19668521?tool=bestpractice.com
Primary options
ganciclovir ophthalmic: (0.15%) children ≥2 years of age and adults: consult specialist for guidance on dose
observation ± topical or oral antivirals
Herpes simplex virus (HSV) conjunctivitis is usually self-limiting, but may need treatment with topical or oral antivirals in more severe disease, particularly if corneal involvement is suspected.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext For the management of HSV keratitis, please see Keratitis.
prompt referral to an ophthalmologist
Prompt referral to an ophthalmologist is required for all patients who have eye manifestations of herpes zoster infection.[99]Dworkin RH, Johnson RW, Breuer J, et al. Recommendations for the management of herpes zoster. Clin Infect Dis. 2007 Jan 1;44 Suppl 1:S1-26. https://academic.oup.com/cid/article/44/Supplement_1/S1/334966 http://www.ncbi.nlm.nih.gov/pubmed/17143845?tool=bestpractice.com See Herpes zoster infection.
observation ± removal of lesions
Lesions generally resolve over time; the natural course of infection is spontaneous clearance in 1-2 years in most immunocompetent patients, with more prolonged illness in immunocompromised patients. The lesions may need to be removed in symptomatic patients.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
neonatal conjunctivitis
immediate referral to an ophthalmologist
This is conjunctival inflammation occurring within the first 30 days of life. It is also known as ophthalmia neonatorum. It is usually a mild illness. However, untreated infection (for example, with gonococcus, chlamydia, pseudomonas, or herpes) can lead to sight-threatening complications and potentially serious systemic infection.[100]Recommendations for the prevention of neonatal ophthalmia. Paediatr Child Health. 2002 Sep;7(7):480-3. https://academic.oup.com/pch/article/7/7/480/2654200 http://www.ncbi.nlm.nih.gov/pubmed/20046325?tool=bestpractice.com Complications of neonatal conjunctivitis due to chlamydia include superficial corneal vascularisation, conjunctival scarring, and pneumonia. Complications due to gonorrhoeal infections include corneal scarring, ulceration, panophthalmitis, perforation of the globe, and permanent visual impairment.[100]Recommendations for the prevention of neonatal ophthalmia. Paediatr Child Health. 2002 Sep;7(7):480-3. https://academic.oup.com/pch/article/7/7/480/2654200 http://www.ncbi.nlm.nih.gov/pubmed/20046325?tool=bestpractice.com [101]Matejcek A, Goldman RD. Treatment and prevention of ophthalmia neonatorum. Can Fam Physician. 2013 Nov;59(11):1187-90. https://www.cfp.ca/content/59/11/1187.long http://www.ncbi.nlm.nih.gov/pubmed/24235191?tool=bestpractice.com Patients with suspected neonatal conjunctivitis should be referred immediately to an ophthalmologist.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
contact lens related
topical corticosteroid
A brief course (1 to 2 weeks) of a topical corticosteroid can be prescribed to reduce irritation and inflammation. Only ophthalmic clinicians should prescribe topical corticosteroids. Contact lens wear should be discontinued for 2 or more weeks, and the lens care regimen should be reviewed and changed to a preservative-free lens care system. Contact lens-related keratoconjunctivitis can potentially impact visual function, so referral to an eye specialist should be considered.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
Primary options
loteprednol ophthalmic: (0.5%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
OR
prednisolone ophthalmic: (1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) two to four times daily
topical fluoroquinolone
Additional treatment recommended for SOME patients in selected patient group
If bacterial, topical fluoroquinolones should be prescribed.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext [83]Sheikh A, Hurwitz B. Topical antibiotics for acute bacterial conjunctivitis: a systematic review. Br J Gen Pract. 2001 Jun;51(467):473-7. http://www.ncbi.nlm.nih.gov/pubmed/11407054?tool=bestpractice.com [88]Mah F. Bacterial conjunctivitis in pediatrics and primary care. Pediatr Clin North Am. 2006 May;53 Suppl 1:7-10; quiz 11, 13-5. http://www.ncbi.nlm.nih.gov/pubmed/16898650?tool=bestpractice.com [89]Alfonso E, Crider J. Ophthalmic infections and their anti-infective challenges. Surv Ophthalmol. 2005 Nov;50 Suppl 1:S1-6. http://www.ncbi.nlm.nih.gov/pubmed/16257307?tool=bestpractice.com [90]Silverstein BE, Morris TW, Gearinger LS, et al. Besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis patients with Pseudomonas aeruginosa infections. Clin Ophthalmol. 2012;6:1987-96. https://www.dovepress.com/getfile.php?fileID=14611 http://www.ncbi.nlm.nih.gov/pubmed/23233796?tool=bestpractice.com [94]Sanfilippo CM, Allaire CM, DeCory HH. Besifloxacin ophthalmic suspension 0.6% compared with gatifloxacin ophthalmic solution 0.3% for the treatment of bacterial conjunctivitis in neonates. Drugs R D. 2017 Mar;17(1):167-75. https://link.springer.com/article/10.1007%2Fs40268-016-0164-6 http://www.ncbi.nlm.nih.gov/pubmed/28078599?tool=bestpractice.com [95]O'Brien TP. Besifloxacin ophthalmic suspension, 0.6%: a novel topical fluoroquinolone for bacterial conjunctivitis. Adv Ther. 2012 Jun;29(6):473-90. http://www.ncbi.nlm.nih.gov/pubmed/22729919?tool=bestpractice.com
Antibiotics should be continued for 7 days.
Primary options
besifloxacin ophthalmic: (0.6%) children ≥1 year of age and adults: 1 drop into the affected eye(s) three times daily
OR
ofloxacin ophthalmic: (0.3%) children ≥1 year of age and adults: 1-2 drops into the affected eye(s) every 2-4 hours for 2 days, then four times daily
OR
ciprofloxacin ophthalmic: (0.3%) children and adults: 1 drop into the affected eye(s) every 2 hours for 2 days, then every 4 hours
OR
levofloxacin ophthalmic: (0.5%) children ≥6 years of age and adults: 1-2 drops into the affected eye(s) every 2 hours up to eight times daily for 2 days, then every 4 hours up to four times daily
OR
moxifloxacin ophthalmic: (0.5%) children and adults: 1 drop into the affected eye(s) three times daily
OR
gatifloxacin ophthalmic: (0.5%) children ≥1 year of age and adults: 1 drop into the affected eye(s) every 2 hours up to eight times daily for 1 day, then two to four times daily
mechanical conjunctivitis
supportive measures
Ocular lubricants may help in managing mild cases.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
Temporary relief of floppy eyelid syndrome may be achieved by taping the patient's eyelids shut or by having the patient wear a protective shield while sleeping.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
surgery
Additional treatment recommended for SOME patients in selected patient group
Surgical procedures such as full-thickness horizontal shortening of the upper eyelid, to prevent the upper eyelid from overlapping, can be considered for more severe cases.[1]Cheung, Albert Y. et al. Conjunctivitis preferred practice pattern. Ophthalmology. 2024 Feb 12;131(4): 134-204. https://www.aaojournal.org/article/S0161-6420(24)00009-5/fulltext
toxic/chemical conjunctivitis
eye irrigation and artificial tears ± corticosteroid
The eye should be immediately flushed following any exposure and the pH of the tears checked. Flushing should occur until the pH is 7.
Artificial tears should be used frequently to provide symptomatic relief.
A short course of topical corticosteroids can be considered if inflammation persists. Only ophthalmic clinicians should prescribe topical corticosteroids.
Primary options
loteprednol ophthalmic: (0.5%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
OR
prednisolone ophthalmic: (1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) two to four times daily
medicine-related conjunctivitis
discontinue medication ± artificial tears ± corticosteroid
Discontinuation of the drug causing medication-induced conjunctivitis usually results in gradual resolution of symptoms over several weeks or months.
Preservative-free artificial tears may provide symptomatic relief.
If severe inflammation of the conjunctiva or eyelid is present, a brief course of topical corticosteroids can be considered. However, only ophthalmic clinicians should prescribe topical corticosteroids.
Primary options
loteprednol ophthalmic: (0.5%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) four times daily
OR
prednisolone ophthalmic: (1%) children ≥2 years of age and adults: 1-2 drops into the affected eye(s) two to four times daily
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Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups. See disclaimer
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