Epidemiology

Surveillance data suggest haemophilia incidence of 1 in 4334 live male births in the US.[4] The exact number of people living with haemophilia in the US is not known; however, based on data collected during the period 2012-2018, it is thought that as many as 33,000 males in the US are living with the disorder.[4][5] In the UK, the Haemophilia Society estimates that around 6000 have haemophilia. The Haemophilia Society Opens in new window

Congenital haemophilia affects all ethnic groups and has a worldwide distribution.[6] Its inheritance pattern is X-linked.[7] Therefore, boys and/or men are almost exclusively affected, although many female carriers (approximately 30%) have clotting factor levels in the haemophilia range due to lyonization (random inactivation of the normal X chromosome) and may have bleeding symptoms requiring appropriate management. Rare cases of girls and/or women with severe haemophilia are described because of extreme lyonization, homozygosity, mosaicism, or Turner syndrome. Acquired haemophilia is rare, with an incidence of acquired haemophilia A in the UK of 1.48 per million per year.[8]

Acquired haemophilia affects around 1 to 3 people per million of the population. Both sexes are equally affected. As with the conventional inherited form, the condition appears in all ethnic groups and has a worldwide prevalence.

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