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Last reviewed: 21 Apr 2025
Last updated: 02 Apr 2025

Summary

Definition

History and exam

Key diagnostic factors

  • malignancy
  • presence of other risk factors
  • dyspnoea
  • raised jugular venous pressure (JVP)
  • distant heart sounds
  • pulsus paradoxus
  • hypotension
  • tachycardia
  • recent cardiac surgery or intervention
  • Beck's triad: hypotension, distant heart sounds, and raised JVP

Other diagnostic factors

  • chest pain
  • abdominal pain
  • fever
  • pericardial rub

Risk factors

  • malignancy
  • aortic dissection
  • purulent pericarditis
  • large idiopathic chronic pericardial effusion
  • post-cardiac surgery or intervention
  • tuberculosis (TB)
  • autoimmune disease
  • hypothyroidism
  • end-stage renal failure
  • anticoagulation

Diagnostic investigations

1st investigations to order

  • ECG
  • transthoracic echocardiogram
  • CXR
  • FBC
  • erythrocyte sedimentation rate/CRP
  • cardiac enzymes

Investigations to consider

  • cardiac CT
  • cardiac MRI
  • cardiac catheterisation
  • pericardiocentesis fluid for culture and cytology

Treatment algorithm

Contributors

Authors

Antonio Abbate, MD, PhD

Ruth C. Heede Professor of Cardiovascular Medicine

Division of Cardiovascular Medicine

Berne Cardiovascular Research Center

University of Virginia School of Medicine

Charlottesville

VA

Disclosures

AA has received consultant fees from Kiniksa Pharmaceuticals. He is an author of references cited in this topic.

Acknowledgements

Dr Antonio Abbate would like to gratefully acknowledge Dr Vaikom S. Mahadevan, Dr Harsh Agrawal, Dr Jonathan Bella, Dr Liran Blum, and Dr Michael Spinelli, previous contributors to this topic.

Disclosures

VSM declares that he is a proctor for Edwards Lifesciences for transcatheter valves and also a proctor for Abbott for closure devices. HA, JB, LB, and MS declare that they have no competing interests.

Peer reviewers

Ramon Castello, MD

Professor of Medicine

Director of Echocardiography

Mayo Clinic

Jacksonville

FL

Disclosures

RC declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Klein AL, Abbara S, Agler DA, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease: endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2013 Sep;26(9):965-1012.Full text  Abstract

Adler Y, Charron P, Imazio M, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases. Eur Heart J. 2015 Nov 7;36(42):2921-64.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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