Prognosis
Neurodegeneration is rapidly progressive in progressive supranuclear palsy (PSP), leading to death within 6-8 years of symptom onset in classical PSP-Richardson’s syndrome (PSP-RS).[10][136]
Survival is affected by disease phenotype, with the shortest survival prognosis for PSP-RS and the longest for PSP-parkinsonism (PSP-P) and PSP with progressive gait freezing (PSP-PGF). In one study, PSP-RS and PSP-P were found to have an estimated mean survival time of 6.8 years and 11.2 years, respectively.[137] Another study found that survival in PSP-PGF can be as high as 19 years after symptom onset, with a mean disease duration of 11.5 years.[138]
Early falls, cognitive impairment, and dysphagia are other factors that can negatively affect survival, especially when presenting early.[28][139]
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