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Last reviewed: 21 Apr 2025
Last updated: 24 Apr 2025

Summary

Your Organisational Guidance

ebpracticenet urges you to prioritise the following organisational guidance:

Behandeling acuut coronair syndroom in een urgente situatie (in afwachting van hospitalisatie)Published by: Werkgroep Ontwikkeling Richtlijnen Eerste Lijn (Worel)Last published: 2022La prise en charge du syndrome coronarien aigu (SCA) en situation d'urgence (en attente d'hospilatisation)Published by: Groupe de Travail Développement de recommmandations de première ligneLast published: 2022

Definition

History and exam

Key diagnostic factors

  • chest pain
  • risk factors for cardiovascular disease
  • marked sweating
  • cardiogenic shock
  • acute heart failure

Other diagnostic factors

  • nausea and vomiting
  • arrhythmias
  • Abnormal heart sounds
  • epigastric pain
  • dyspnoea
  • syncope
  • back pain

Risk factors

  • smoking
  • hypertension
  • diabetes
  • obesity and metabolic syndrome phenotype
  • sedentary behaviour and physical inactivity
  • dyslipidaemia
  • chronic kidney disease
  • atherosclerosis (history of angina, myocardial infarction, stroke, transient ischaemic attack, peripheral vascular disease)
  • family history of premature coronary artery disease
  • age >60 years
  • cocaine use
  • depression
  • stent thrombosis or restenosis
  • sleep apnoea
  • surgical procedures (including intra-operative and postoperative periods)
  • migraine
  • adverse pregnancy outcomes

Diagnostic investigations

1st investigations to order

  • ECG
  • high-sensitivity troponin
  • echocardiography
  • chest x-ray
  • full blood count
  • urea, electrolytes, and creatinine
  • liver function tests
  • blood glucose
  • C-reactive protein

Investigations to consider

  • invasive coronary angiography (ICA)
  • lipids

Treatment algorithm

Contributors

Expert advisers

Shrilla Banerjee, MD, FRCP

Consultant Interventional Cardiologist

East Surrey Hospital

Surrey and Sussex Healthcare NHS Trust

UK

Disclosures

SB has received speaker fees for educational lectures (presentation content was her own) and meeting participation from Menarini, Edwards Lifesciences, Abbott Vascular, and Shockwave IVL. She has also participated in an Advisory Board for Sahajanand Medical Technologies Limited. SB has received travel sponsorship from Biosensors International to attend the PCR meeting in Paris in 2022. She has prepared a manuscript on coronary microvascular dysfunction for Abbott for Cardiovascular News (no royalties).

Adam Hartley, MBBS, BSc, MRCP

Wellcome Trust Clinical Research Fellow

Imperial College London

Specialist Registrar in Cardiology

Imperial College Healthcare NHS Trust

London

UK

Disclosures

AH declares that he has no competing interests.

Acknowledgements

BMJ Best Practice would like to gratefully acknowledge the previous expert contributors, whose work has been retained in parts of the content:

Resham Baruah MBBS, BSc MRCP, PhD

Consultant Cardiologist

Chelsea and Westminster Hospital NHS Foundation Trust

Royal Brompton & Harefield NHS Foundation Trust

London

UK

Cody S Deen, MD

Assistant Professor of Medicine

Director of Cardiology

Hillsborough Hospital

University of North Carolina

Hillsborough

NC

Disclosures

RB has received honoraria/speakers’ fees from Novartis and Boehringer Ingelheim. CSD was previously the Director of Cardiac Rehab for Chatham Hospital, which was financially set up as a consultancy relationship, until 2017. CSD has spoken (unpaid) at the Update in Cardiology and Update in Internal Medicine Conferences at UNC for the last 5 years. CSD has served as the PI for the Dal-GeneE (site now closed) and the ACCELERATE Trials at the University of North Carolina (trial now completed). Each trial required paid travel to an investigator meeting.

Peer reviewers

Gavin Galasko, BM, BCh, MA, DM (Oxon), FRCP

Consultant Interventional Cardiologist

Director of Research, Development and Innovation

Blackpool Teaching Hospitals NHS Foundation Trust

Blackpool

UK

Disclosures

GG declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-228.Full text  Abstract

Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 12;44(38):3720-826.Full text  Abstract

National Institute for Health and Care Excellence. Acute coronary syndromes. Nov 2020 [internet publication].Full text

National Institute for Health and Care Excellence. Recent-onset chest pain of suspected cardiac origin: assessment and diagnosis. Nov 2016 [internet publication].Full text

Reference articles

A full list of sources referenced in this topic is available here.

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