References

Key articles

Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

American Diabetes Association. Standards of care in diabetes -2025. Diabetes Care. 2025 Jan 1;48(Suppl 1): S1-343.Full text

Dhatariya KK, Glaser NS, Codner E, et al. Diabetic ketoacidosis. Nat Rev Dis Primers. 2020 May 14;6(1):40. Abstract

National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].Full text

Reference articles

1. Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

2. Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

3. Heddy N. Guideline for the management of children and young people under the age of 18 years with diabetic ketoacidosis (British Society for Paediatric Endocrinology and Diabetes). Arch Dis Child Educ Pract Ed. 2021 Aug;106(4):220-2.

4. Mauvais-Jarvis F, Sobngwi E, Porcher R, et al. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes. 2004;53:645-653.Full text  Abstract

5. Umpierrez GE. Ketosis-prone type 2 diabetes: time to revise the classification of diabetes. Diabetes Care. 2006 Dec;29(12):2755-7.Full text

6. American Diabetes Association. Standards of care in diabetes -2025. Diabetes Care. 2025 Jan 1;48(Suppl 1): S1-343.Full text

7. Al-Hindi B, Mohammed MA, Mangantig E, et al. Prevalence of sodium-glucose transporter 2 inhibitor-associated diabetic ketoacidosis in real-world data: A systematic review and meta-analysis. J Am Pharm Assoc (2003). 2024 Jan-Feb;64(1):9-26.e6.Full text  Abstract

8. Umpierrez GE, Woo W, Hagopian WA, et al. Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis. Diabetes Care. 1999 Sep;22(9):1517-23. Abstract

9. Umpierrez GE, Smiley D, Kitabchi AE. Narrative review: ketosis-prone type 2 diabetes mellitus. Ann Intern Med. 2006;144:350-357. Abstract

10. Kitabchi AE, Umpierrez GE, Fisher JN, et al. Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state. J Clin Endocrinol Metab. 2008;93:1541-1552. Abstract

11. Dhatariya KK, Glaser NS, Codner E, et al. Diabetic ketoacidosis. Nat Rev Dis Primers. 2020 May 14;6(1):40. Abstract

12. Kovacs A, Bunduc S, Veres DS, et al. One third of cases of new-onset diabetic ketosis in adults are associated with ketosis-prone type 2 diabetes-A systematic review and meta-analysis. Diabetes Metab Res Rev. 2024 Mar;40(3):e3743.Full text  Abstract

13. Lebovitz HE, Banerji MA. Ketosis-prone diabetes (flatbush diabetes): an emerging worldwide clinically important entity. Curr Diab Rep. 2018 Oct 2;18(11):120.Full text  Abstract

14. Zhong VW, Juhaeri J, Mayer-Davis EJ. Trends in hospital admission for diabetic ketoacidosis in adults with type 1 and type 2 diabetes in England, 1998-2013: A retrospective cohort study. Diabetes Care. 2018 Sep;41(9):1870-7. Abstract

15. Benoit SR, Zhang Y, Geiss LS, et al. Trends in diabetic ketoacidosis hospitalizations and in-hospital mortality - United States, 2000-2014. MMWR Morb Mortal Wkly Rep. 2018 Mar 30;67(12):362-365.Full text  Abstract

16. McCoy RG, Herrin J, Galindo RJ, et al. Rates of hypoglycemic and hyperglycemic emergencies among U.S. adults with diabetes, 2011-2020. Diabetes Care. 2023 Feb 1;46(2):e69-71.Full text

17. Centers for Disease Control and Prevention. Diabetes: national diabetes statistics report. May 2024 [internet publication].Full text

18. Nyenwe EA, Kitabchi AE. The evolution of diabetic ketoacidosis: an update of its etiology, pathogenesis and management. Metabolism. 2016 Apr;65(4):507-21. Abstract

19. Umpierrez G, Korytkowski M. Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol. 2016 Apr;12(4):222-32. Abstract

20. Karslioglu French E, Donihi AC, Korytkowski MT. Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients. BMJ. 2019 May 29;365:l1114.Full text  Abstract

21. Nyenwe EA, Loganathan RS, Blum S, et al. Active use of cocaine: an independent risk factor for recurrent diabetic ketoacidosis in a city hospital. Endocr Pract. 2007 Jan-Feb;13(1):22-9. Abstract

22. Vuk A, Baretic M, Osvatic MM, et al. Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review. J Clin Psychopharmacol. 2017 Oct;37(5):584-9. Abstract

23. Byun DJ, Braunstein R, Flynn J, et al. Immune checkpoint inhibitor-associated diabetes: a single-institution experience. Diabetes Care. 2020 Dec;43(12):3106-9.Full text  Abstract

24. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Sep;38(9):1687-93. Abstract

25. Kum-Nji JS, Gosmanov AR, Steinberg H, et al. Hyperglycemic, high anion-gap metabolic acidosis in patients receiving SGLT-2 inhibitors for diabetes management. J Diabetes Complications. 2017 Mar;31(3):611-4. Abstract

26. Hampp C, Swain RS, Horgan C, et al. Use of sodium-glucose cotransporter 2 inhibitors in patients with type 1 diabetes and rates of diabetic ketoacidosis. Diabetes Care. 2020 Jan;43(1):90-7. Abstract

27. US Food and Drug Administration. FDA drug safety communication: FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections. December 2015 [internet publication].Full text

28. Horii T, Oikawa Y, Atsuda K, et al. On-label use of sodium-glucose cotransporter 2 inhibitors might increase the risk of diabetic ketoacidosis in patients with type 1 diabetes. J Diabetes Investig. 2021 Sep;12(9):1586-93.Full text  Abstract

29. Douros A, Lix LM, Fralick M, et al. Sodium-glucose cotransporter-2 inhibitors and the risk for diabetic ketoacidosis: a multicenter cohort study. Ann Intern Med. 2020 Sep 15;173(6):417-25. Abstract

30. Danne T, Garg S, Peters AL, et al. International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium-glucose cotransporter (SGLT) inhibitors. Diabetes Care. 2019 Jun;42(6):1147-54.Full text  Abstract

31. Davies MJ, Aroda VR, Collins BS, et al. Management of hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2022 Nov 1;45(11):2753-2786.Full text  Abstract

32. Stentz FB, Umpierrez GE, Cuervo R, et al. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes. 2004;53:2079-2086.Full text  Abstract

33. Razavi Nematollahi L, Kitabchi AE, Stentz FB, et al. Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects. Metabolism. 2009;58:443-448. Abstract

34. McCoy RG, Galindo RJ, Swarna KS, et al. Sociodemographic, clinical, and treatment-related factors associated with hyperglycemic crises among adults with type 1 or type 2 diabetes in the US from 2014 to 2020. JAMA Netw Open. 2021 Sep 1;4(9):e2123471.Full text  Abstract

35. Randall L, Begovic J, Hudson M, et al. Recurrent diabetic ketoacidosis in inner-city minority patients: behavioral, socioeconomic, and psychosocial factors. Diabetes Care. 2011 Sep;34(9):1891-6.Full text  Abstract

36. Price HC, Ismail K, Joint British Diabetes Societies (JBDS) for Inpatient Care. Royal College of Psychiatrists Liaison Faculty & Joint British Diabetes Societies (JBDS): guidelines for the management of diabetes in adults and children with psychiatric disorders in inpatient settings. Diabet Med. 2018 Aug;35(8):997-1004. Abstract

37. Lindner LME, Rathmann W, Rosenbauer J. Inequalities in glycaemic control, hypoglycaemia and diabetic ketoacidosis according to socio-economic status and area-level deprivation in Type 1 diabetes mellitus: a systematic review. Diabet Med. 2018 Jan;35(1):12-32. Abstract

38. Hamblin PS, Topliss DJ, Chosich N, et al. Deaths associated with diabetic ketoacidosis and hyperosmolar coma. 1973-1988. Med J Aust. 1989 Oct 16;151:439-44. Abstract

39. Hurtado CR, Lemor A, Vallejo F, et al. Causes and predictors for 30-day re-admissions in adult patients with diabetic ketoacidosis in the united states: a nationwide analysis, 2010-2014. Endocr Pract. 2019 Mar;25(3):242-53. Abstract

40. Everett E, Mathioudakis NN. Association of socioeconomic status and DKA readmission in adults with type 1 diabetes: analysis of the US national readmission database. BMJ Open Diabetes Res Care. 2019;7(1):e000621.Full text  Abstract

41. Thomas M, Harjutsalo V, Feodoroff M, et al. The Long-term incidence of hospitalization for ketoacidosis in adults with established T1D-A prospective cohort study. J Clin Endocrinol Metab. 2020 Jan 1;105(1):dgz003.Full text  Abstract

42. Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA. Am J Gastroenterol. 2000 Oct;95(10):2795-800. Abstract

43. Kopff B, Mucha S, Wolffenbuttel BH, et al. Diabetic ketoacidosis in a patient with acromegaly. Med Sci Monit. 2001 Jan-Feb;7(1):142-7. Abstract

44. Cooppan R, Kozak GP. Hyperthyroidism and diabetes mellitus. An analysis of 70 patients. Arch Intern Med. 1980 Mar;140(3):370-3. Abstract

45. Rathish D, Karalliyadda S. Concurrent presentation of thyroid storm and diabetic ketoacidosis: a systematic review of previously reported cases. BMC Endocr Disord. 2019 May 17;19(1):49.Full text  Abstract

46. Colacci M, Fralick J, Odutayo A, et al. Sodium-Glucose Cotransporter-2 Inhibitors and Risk of Diabetic Ketoacidosis Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis. Can J Diabetes. 2022 Feb;46(1):10-15.e2.Full text  Abstract

47. Chen MB, Xu RJ, Zheng QH, et al. Efficacy and safety of sotagliflozin adjuvant therapy for type 1 diabetes mellitus: a systematic review and meta-analysis. Medicine (Baltimore). 2020 Aug 14;99(33):e20875.Full text  Abstract

48. Miyoshi Y, Ogawa O, Oyama Y. Nivolumab, an anti-programmed cell death-1 antibody, induces fulminant type 1 diabetes. Tohoku J Exp Med. 2016 Jun;239(2):155-8.Full text  Abstract

49. Clotman K, Janssens K, Specenier P, et al. Programmed cell death-1 (PD-1) inhibitor induced type 1 diabetes mellitus: mini-review. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3144-54. Abstract

50. Akturk HK, Kahramangil D, Sarwal A, et al. Immune checkpoint inhibitor-induced type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2019 Sep;36(9):1075-81.Full text  Abstract

51. Association of British Clinical Diabetologists. JBDS 17 the management of glycaemic control in people with cancer. Jan 2023 [internet publication].Full text

52. Acharya R, Kabadi UM. Case of diabetic ketoacidosis as an initial presentation of Cushing's syndrome. Endocrinol Diabetes Metab Case Rep. 2017 Feb 23;2017:16-0123.Full text  Abstract

53. Kirwan JP, Aminian A, Kashyap SR, Bet al. Bariatric surgery in obese patients with type 1 diabetes. Diabetes Care. 2016 Jun;39(6):941-8.Full text  Abstract

54. Parmar C, Appel S, Lee L, et al. Choice of bariatric surgery in patients with obesity and type 1 diabetes mellitus? an up-to-date systematic review. Obes Surg. 2022 Dec;32(12):3992-4006. Abstract

55. Tamsett Z, James S, Brown F, et al. Modifiable factors to prevent severe hypoglycaemic and diabetic ketoacidosis presentations in people with type 1 diabetes. Diabet Med. 2024 Sep;41(9):e15384.Full text  Abstract

56. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].Full text

57. Blonde L, Umpierrez GE, Reddy SS, et al. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. Endocr Pract. 2022 Oct;28(10):923-1049.Full text  Abstract

58. National Institute for Health and Care Excellence. Type 2 diabetes in adults: management. Jun 2022 [internet publication].Full text

59. Henry RR, Dandona P, Pettus J, et al. Dapagliflozin in patients with type 1 diabetes: A post hoc analysis of the effect of insulin dose adjustments on 24-hour continuously monitored mean glucose and fasting β-hydroxybutyrate levels in a phase IIa pilot study. Diabetes Obes Metab. 2017 Jun;19(6):814-821. Abstract

60. Goldenberg RM, Berard LD, Cheng AY, et al. SGLT2 inhibitor-associated diabetic ketoacidosis: clinical review and recommendations for prevention and diagnosis. Clin Ther. 2016 Dec;38(12):2654-64.e1. Abstract

61. Goldenberg RM, Gilbert JD, Hramiak IM, et al. Sodium-glucose co-transporter inhibitors, their role in type 1 diabetes treatment and a risk mitigation strategy for preventing diabetic ketoacidosis: the STOP DKA protocol. Diabetes Obes Metab. 2019 Oct;21(10):2192-202. Abstract

62. Phillip M, Achenbach P, Addala A, et al. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetes Care. 2024 Aug 1;47(8):1276-98.Full text  Abstract

63. Misra S, Oliver NS. Diabetic ketoacidosis in adults. BMJ. 2015 Oct 28;351:h5660. Abstract

64. Evans K. Diabetic ketoacidosis: update on management. Clin Med (Lond). 2019 Sep;19(5):396-8.Full text  Abstract

65. National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].Full text  Abstract

66. Umpierrez G, Freire AX. Abdominal pain in patients with hyperglycemic crises. J Crit Care. 2002 Mar;17(1):63-7. Abstract

67. Trachtenbarg DE. Diabetic ketoacidosis. Am Fam Physician. 2005 May 1;71(9):1705-14. Abstract

68. Gosmanov AR, Gosmanova EO, Dillard-Cannon E. Management of adult diabetic ketoacidosis. Diabetes Metab Syndr Obes. 2014 Jun 30;7:255-64. Abstract

69. Pryce R. Diabetic ketoacidosis caused by exposure of insulin pump to heat and sunlight. BMJ. 2009 Jan 5;338:a2218. Abstract

70. Umpierrez GE, Kitabchi AE. Diabetic ketoacidosis: risk factors and management strategies. Treat Endocrinol. 2003;2(2):95-108. Abstract

71. Vuk A, Kuzman MR, Baretic M, et al. Diabetic ketoacidosis associated with antipsychotic drugs: case reports and a review of literature. Psychiatr Danub. 2017 Jun;29(2):121-35. Abstract

72. Kotwal A, Haddox C, Block M, et al. Immune checkpoint inhibitors: an emerging cause of insulin-dependent diabetes. BMJ Open Diabetes Res Care. 2019 Feb 13;7(1):e000591.Full text  Abstract

73. Joharatnam-Hogan N, Chambers P, Dhatariya K, et al. A guideline for the outpatient management of glycaemic control in people with cancer. Diabet Med. 2021 Jul 9 [Epub ahead of print].Full text  Abstract

74. Kinney GL, Akturk HK, Taylor DD, et al. Cannabis use is associated with increased risk for diabetic ketoacidosis in adults with type 1 diabetes: findings from the T1D Exchange Clinic Registry. Diabetes Care. 2020 Jan;43(1):247-9. Abstract

75. Sarkar M, Madabhavi I, Niranjan N, et al. Auscultation of the respiratory system. Ann Thorac Med. 2015 Jul-Sep;10(3):158-68.Full text  Abstract

76. Konstantinov NK, Rohrscheib M, Agaba EI, et al. Respiratory failure in diabetic ketoacidosis. World J Diabetes. 2015 Jul 25;6(8):1009-23.Full text  Abstract

77. Lim WS, Baudouin SV, George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax. 2009 Oct;64(suppl 3):iii1-55.Full text  Abstract

78. Mandell LA, Niederman MS. Aspiration pneumonia. N Engl J Med. 2019 Feb 14;380(7):651-63. Abstract

79. Kitabchi AE, Wall BM. Management of diabetic ketoacidosis. Am Fam Physician. 1999 Aug;60(2):455-64. Abstract

80. Meaden CW, Kushner BJ, Barnes S. A rare and lethal complication: cerebral edema in the adult patient with diabetic ketoacidosis. Case Rep Emerg Med. 2018 Mar 21;2018:5043752.Full text  Abstract

81. Westerberg DP. Diabetic ketoacidosis: evaluation and treatment. Am Fam Physician. 2013 Mar 1;87(5):337-46. Abstract

82. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication].Full text

83. Elmas ÖN, Akıncı A, Bilir P. Tuberculous meningitis associated with diabetic ketoacidosis. J Clin Res Pediatr Endocrinol. 2011;3(4):222-4.Full text  Abstract

84. Newton CA, Raskin P. Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus: clinical and biochemical differences. Arch Intern Med. 2004 Sep 27;164(17):1925-31.Full text  Abstract

85. Elendu C, David JA, Udoyen AO, et al. Comprehensive review of diabetic ketoacidosis: an update. Ann Med Surg (Lond). 2023 Jun;85(6):2802-7.Full text  Abstract

86. Modi A, Agrawal A, Morgan F. Euglycemic diabetic ketoacidosis: a review. Curr Diabetes Rev. 2017;13(3):315-21. Abstract

87. Hansen BA, Bruserud Ø. Hypomagnesemia in critically ill patients. J Intensive Care. 2018 Mar 27;6:21.Full text  Abstract

88. Lowie BJ, Bond MC. Diabetic ketoacidosis. Emerg Med Clin North Am. 2023 Nov;41(4):677-86. Abstract

89. Nyenwe EA, Razavi LN, Kitabchi AE, et al. Acidosis: the prime determinant of depressed sensorium in diabetic ketoacidosis. Diabetes Care. 2010 Aug;33(8):1837-9.Full text  Abstract

90. Goldberger ZD. Severe hypothermia with Osborn waves in diabetic ketoacidosis. Respir Care. 2008 Apr;53(4):500-2. Abstract

91. Mohan M, Baagar KAM, Lindow S. Management of diabetic ketoacidosis in pregnancy. Obstet Gynecol. 2017 Jan 24;19(1):55–62.

92. Agarwal A, Yadav A, Gutch M, et al. Prognostic factors in patients hospitalized with diabetic ketoacidosis. Endocrinol Metab (Seoul). 2016 Sep;31(3):424-32. Abstract

93. Polonsky WH, Anderson BJ, Lohrer PA, et al. Insulin omission in women with IDDM. Diabetes Care. 1994 Oct;17(10):1178-85. Abstract

94. Jamshed N, Banavaliker B, Aggarwal P. Catamenial diabetic ketoacidosis - a diagnostic dilemma in ED. Am J Emerg Med. 2013 Feb;31(2):464.e1-3. Abstract

95. Ovalle F, Vaughan TB 3rd, Sohn JE, et al. Catamenial diabetic ketoacidosis and catamenial hyperglycemia: case report and review of the literature. Am J Med Sci. 2008 Apr;335(4):298-303. Abstract

96. Khafaji HA, Suwaidi JM. Atypical presentation of acute and chronic coronary artery disease in diabetics. World J Cardiol. 2014 Aug 26;6(8):802-13.Full text  Abstract

97. Junghans C, Sekhri N, Zaman MJ, et al. Atypical chest pain in diabetic patients with suspected stable angina: impact on diagnosis and coronary outcomes. Eur Heart J Qual Care Clin Outcomes. 2015 Jul 1;1(1):37-43.Full text  Abstract

98. Kamalakannan D, Baskar V, Barton DM, et al. Diabetic ketoacidosis in pregnancy. Postgrad Med J. 2003 Aug;79(934):454-7.Full text  Abstract

99. Cartwright SL, Knudson MP. Evaluation of acute abdominal pain in adults. Am Fam Physician. 2008 Apr 1;77(7):971-8. Abstract

100. Jackson PG, Raiji MT. Evaluation and management of intestinal obstruction. Am Fam Physician. 2011 Jan 15;83(2):159-65. Abstract

101. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 Jul;34(7):1517-8.Full text  Abstract

102. Valette X, du Cheyron D. Images in clinical medicine. Cullen's and Grey Turner's signs in acute pancreatitis. N Engl J Med. 2015 Dec 10;373(24):e28. Abstract

103. Rawla P, Vellipuram AR, Bandaru SS, et al. Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma. Endocrinol Diabetes Metab Case Rep. 2017 Sep 4;2017:17-0081.Full text  Abstract

104. Robles FC, Laguna Neto D, Dias FG, et al. Diabetic ketoacidosis: difference between potassium determined by blood gas analysis versus plasma measurement. Arq Bras Endocrinol Metabol. 2011 Jun;55(4):256-9. Abstract

105. Fu P, Douros G, Kelly AM. Does potassium concentration measured on blood gas analysis agree with serum potassium in patients with diabetic ketoacidosis? Emerg Med Australas. 2004 Aug;16(4):280-3. Abstract

106. Kelly AM. Can VBG analysis replace ABG analysis in emergency care? Emerg Med J. 2016 Feb;33(2):152-4. Abstract

107. Byrne AL, Bennett M, Chatterji R, et al. Peripheral venous and arterial blood gas analysis in adults: are they comparable? A systematic review and meta-analysis. Respirology. 2014 Feb;19(2):168-75.Full text  Abstract

108. Bloom BM, Grundlingh J, Bestwick JP, et al. The role of venous blood gas in the emergency department: a systematic review and meta-analysis. Eur J Emerg Med. 2014 Apr;21(2):81-8. Abstract

109. Toftegaard M, Rees SE, Andreassen S. Correlation between acid-base parameters measured in arterial blood and venous blood sampled peripherally, from vena cavae superior, and from the pulmonary artery. Eur J Emerg Med. 2008 Apr;15(2):86-91. Abstract

110. Rudkin SE, Kahn CA, Oman JA, et al. Prospective correlation of arterial vs venous blood gas measurements in trauma patients. Am J Emerg Med. 2012 Oct;30(8):1371-7. Abstract

111. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med 2018;56(12):2015-38. Abstract

112. Warren SE. False-positive urine ketone test with captopril. N Engl J Med. 1980 Oct 23;303(17):1003-4.

113. Simerville JA, Maxted WC, Pahira JJ. Urinalysis: a comprehensive review. Am Fam Physician. 2005 Mar 15;71(6):1153-62. Abstract

114. Mercer S, Hanks L, Ashraf A. Rhabdomyolysis in pediatric patients with diabetic ketoacidosis or hyperglycemic hyperosmolar state: a case series. Glob Pediatr Health. 2016 Nov 30;3:2333794X16671391.Full text  Abstract

115. Sauret JM, Marinides G, Wang GK. Rhabdomyolysis. Am Fam Physician. 2002 Mar 1;65(5):907-12. Abstract

116. Birnbaum Y, Drew BJ. The electrocardiogram in ST elevation acute myocardial infarction: correlation with coronary anatomy and prognosis. Postgrad Med J. 2003 Sep;79(935):490-504.Full text  Abstract

117. Levis JT. ECG diagnosis: hypokalemia. Perm J. 2012 Spring;16(2):57.Full text  Abstract

118. Levis JT. ECG diagnosis: hyperkalemia. Perm J. 2013 Winter;17(1):69.Full text  Abstract

119. Yadav D, Nair S, Norkus EP, et al. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. Am J Gastroenterol. 2000 Nov;95(11):3123-8. Abstract

120. National Institute for Health and Care Excellence. Acute coronary syndromes. Nov 2020 [internet publication].Full text

121. Claure-Del Granado R, Mehta RL. Fluid overload in the ICU: evaluation and management. BMC Nephrol. 2016 Aug 2;17(1):109.Full text  Abstract

122. Lal A, Parai JL, Milroy CM. Liver pathology in first presentation diabetic ketoacidosis at autopsy. Acad Forensic Pathol. 2016 Jun;6(2):271-80. Abstract

123. Biegus J, Hillege HL, Postmus D, et al. Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study. Eur J Heart Fail. 2016 Jul;18(7):830-9.Full text  Abstract

124. Long B, Lentz S, Koyfman A, et al. Euglycemic diabetic ketoacidosis: etiologies, evaluation, and management. Am J Emerg Med. 2021 Jun;44:157-60. Abstract

125. Dhatariya K. Blood ketones: measurement, interpretation, limitations, and utility in the management of diabetic ketoacidosis. Rev Diabet Stud. 2016 Winter;13(4):217-25.Full text  Abstract

126. Long B, Willis GC, Lentz S, et al. Diagnosis and management of the critically ill adult patient with hyperglycemic hyperosmolar state. J Emerg Med. 2021 Oct;61(4):365-75. Abstract

127. Stoner GD. Hyperosmolar hyperglycemic state. Am Fam Physician. 2017 Dec 1;96(11):729-36.Full text  Abstract

128. Seheult J, Fitzpatrick G, Boran G. Lactic acidosis: an update. Clin Chem Lab Med. 2017 Mar 1;55(3):322-33.Full text  Abstract

129. Meyer TW, Hostetter TH. Uremia. N Engl J Med. 2007 Sep 27;357(13):1316-25.

130. ELSA. The ELSA study.[internet publication].Full text

131. Type 1 Diabetes Risk in Adults. The type 1 diabetes risk in adults (T1DRA) study. [internet publication].Full text

132. Hardern RD, Quinn ND. Emergency management of diabetic ketoacidosis in adults. Emerg Med J. 2003 May;20(3):210-3.Full text  Abstract

133. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;1(1):CD007798.Full text  Abstract

134. Andrade-Castellanos CA, Colunga-Lozano LE, Delgado-Figueroa N, et al. Subcutaneous rapid-acting insulin analogues for diabetic ketoacidosis. Cochrane Database Syst Rev. 2016 Jan 21;2016(1):CD011281.Full text  Abstract

135. Stuhr K, LeeMaster R, Hickman AW, et al. Subcutaneous insulin versus traditional intravenous insulin infusion in treatment of mild to moderate diabetic ketoacidosis. J Emerg Med. 2023 Sep;65(3):e221-28. Abstract

136. Alnuaimi A, Mach T, Reynier P, et al. A systematic review and meta-analysis comparing outcomes between using subcutaneous insulin and continuous insulin infusion in managing adult patients with diabetic ketoacidosis. BMC Endocr Disord. 2024 Aug 1;24(1):133.Full text  Abstract

137. Kusminsky RE. Complications of central venous catheterization. J Am Coll Surg. 2007 Apr;204(4):681-96.Full text  Abstract

138. McGee DC, Gould MK. Preventing complications of central venous catheterization. N Engl J Med. 2003 Mar 20;348(12):1123-33.Full text  Abstract

139. Smith RN, Nolan JP. Central venous catheters. BMJ. 2013 Nov 11;347:f6570.Full text  Abstract

140. Reich DL. Monitoring in anesthesia and perioperative care. Cambridge: Cambridge University Press; 2011.

141. Abbott Northwestern Hospital Internal Medicine Residency. Internal jugular central venous line. 2022 [internet publication].Full text

142. Bishop L, Dougherty L, Bodenham A, et al. Guidelines on the insertion and management of central venous access devices in adults. Int J Lab Hematol. 2007 Aug;29(4):261-78.Full text  Abstract

143. Practice guidelines for central venous access 2020: an updated report by the American Society of Anesthesiologists Task Force on Central Venous Access. Anesthesiology. 2020 Jan;132(1):8-43.Full text  Abstract

144. Fletcher SJ, Bodenham AR. Safe placement of central venous catheters: where should the tip of the catheter lie? Br J Anaesth. 2000 Aug;85(2):188-91.Full text

145. Gibson F, Bodenham A. Misplaced central venous catheters: applied anatomy and practical management. Br J Anaesth. 2013 Mar;110(3):333-46.Full text

146. Schuster M, Nave H, Piepenbrock S, et al. The carina as a landmark in central venous catheter placement. Br J Anaesth. 2000 Aug;85(2):192-4.Full text

147. Dhatariya KK. Diabetic ketoacidosis. BMJ. 2007 Jun 23;334(7607):1284-5. Abstract

148. van der Jagt M. Fluid management of the neurological patient: a concise review. Crit Care. 2016 May 31;20(1):126.Full text  Abstract

149. Gankam Kengne F, Decaux G. Hyponatremia and the brain. Kidney Int Rep. 2017 Sep 1;3(1):24-35.Full text  Abstract

150. Jahangir A, Jahangir A, Siddiqui FS, et al. Normal saline versus low chloride solutions in treatment of diabetic ketoacidosis: a systematic eeview of clinical trials. Cureus. 2022 Jan;14(1):e21324.Full text  Abstract

151. Self WH, Evans CS, Jenkins CA, et al. Clinical effects of balanced crystalloids vs saline in adults with diabetic ketoacidosis: a subgroup analysis of cluster randomized clinical trials. JAMA Netw Open. 2020 Nov 2;3(11):e2024596.Full text  Abstract

152. Alghamdi NA, Major P, Chaudhuri D, et al. Saline compared to balanced crystalloid in patients with diabetic ketoacidosis: a systematic review and meta-analysis of randomized controlled trials. Crit Care Explor. 2022 Jan;4(1):e0613.Full text  Abstract

153. Catahay JA, Polintan ET, Casimiro M, et al. Balanced electrolyte solutions versus isotonic saline in adult patients with diabetic ketoacidosis: a systematic review and meta-analysis. Heart Lung. 2022 Jul-Aug;54:74-9. Abstract

154. National Patient Safety Agency. ARCHIVED NPSA Alert – Potassium solutions risks to patients from errors occurring during IV administration 2002. July 2002 [internet publication].Full text

155. World Health Organization. Patient safety solution: control of concentrated electrolyte solutions. Feb 2021 [internet publication].Full text

156. Hsieh HC, Wu SH, Chiu CC, et al. Excessive sodium bicarbonate infusion may result in osmotic demyelination syndrome during treatment of diabetic ketoacidosis: a case report. Diabetes Ther. 2019 Apr;10(2):765-71.Full text  Abstract

157. Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis - a systematic review. Ann Intensive Care. 2011 Jul 6;1(1):23.Full text  Abstract

158. Dhatariya KK, Nunney I, Higgins K, et al. National survey of the management of diabetic ketoacidosis (DKA) in the UK in 2014. Diabet Med. 2016 Feb;33(2):252-60. Abstract

159. Al Hanshi S, Shann F. Insulin infused at 0.05 versus 0.1 units/kg/hr in children admitted to intensive care with diabetic ketoacidosis. Pediatr Crit Care Med. 2011 Mar;12(2):137-40. Abstract

160. Nallasamy K, Jayashree M, Singhi S, et al. Low-dose vs standard-dose insulin in pediatric diabetic ketoacidosis: a randomized clinical trial. JAMA Pediatr. 2014 Nov;168(11):999-1005.Full text  Abstract

161. Rameshkumar R, Satheesh P, Jain P, et al. Low-dose (0.05 unit/kg/hour) vs standard-dose (0.1 unit/kg/hour) insulin in the management of pediatric diabetic ketoacidosis: a randomized double-blind controlled trial. Indian Pediatr. 2021 Jul 15;58(7):617-23.Full text  Abstract

162. Dixon AN, Jude EB, Banerjee AK, et al. Simultaneous pulmonary and cerebral oedema, and multiple CNS infarctions as complications of diabetic ketoacidosis: a case report. Diabet Med. 2006 May;23(5):571-3. Abstract

163. Gallo de Moraes A, Surani S. Effects of diabetic ketoacidosis in the respiratory system. World J Diabetes. 2019 Jan 15;10(1):16-22.Full text  Abstract

164. Shand JAD, Morrow P, Braatvedt G. Mortality after discharge from hospital following an episode of diabetic ketoacidosis. Acta Diabetol. 2022 Nov;59(11):1485-92. Abstract

165. McCoy RG, Herrin J, Galindo RJ, et al. All-cause mortality after hypoglycemic and hyperglycemic emergencies among U.S. adults with diabetes, 2011-2020. Diabetes Res Clin Pract. 2023 Mar;197:110263.Full text  Abstract

166. Mays JA, Jackson KL, Derby TA, et al. An evaluation of recurrent diabetic ketoacidosis, fragmentation of care, and mortality across Chicago, Illinois. Diabetes Care. 2016 Oct;39(10):1671-6.Full text  Abstract

167. Gibb FW, Teoh WL, Graham J, et al. Risk of death following admission to a UK hospital with diabetic ketoacidosis. Diabetologia. 2016 Oct;59(10):2082-7.Full text  Abstract

168. Allcock B, Stewart R, Jackson M. Psychosocial factors associated with repeat diabetic ketoacidosis in people living with type 1 diabetes: a systematic review. Diabet Med. 2022 Jan;39(1):e14663.Full text  Abstract

169. Pasquel FJ, Tsegka K, Wang H, et al. Clinical Outcomes in patients with isolated or combined diabetic ketoacidosis and hyperosmolar hyperglycemic state: a retrospective, hospital-based cohort study. Diabetes Care. 2020 Feb;43(2):349-57.Full text  Abstract

170. Hillman K. Fluid resuscitation in diabetic emergencies - a reappraisal. Intensive Care Med. 1987;13(1):4-8. Abstract

171. Morris LR, Murphy MB, Kitabchi AE. Bicarbonate therapy in severe diabetic ketoacidosis. Ann Intern Med. 1986 Dec;105(6):836-40. Abstract

172. Riveline JP, Roussel R, Vicaut E, et al. Reduced rate of aute diabetes events with flash glucose monitoring is sustained for 2 years after initiation: extended outcomes from the RELIEF study. Diabetes Technol Ther. 2022 Sep;24(9):611-8. Abstract

173. Roussel R, Riveline JP, Vicaut E, et al. Important drop in rate of acute diabetes complications in people with type 1 or type 2 diabetes after initiation of flash glucose monitoring in France: the RELIEF study. Diabetes Care. 2021 Jun;44(6):1368-76.Full text  Abstract

174. Albanese-O'Neill A, Wu M, Miller KM, et al. Poor adherence to ketone testing in patients with type 1 diabetes. Diabetes Care. 2017 Apr;40(4):e38-9.Full text

175. Scottish Intercollegiate Guidelines Network (SIGN). Management of diabetes: a national clinical guideline. November 2017 [internet publication].Full text

176. Doherty AM, Gayle C, Morgan-Jones R, et al. Improving quality of diabetes care by integrating psychological and social care for poorly controlled diabetes: 3 dimensions of care for diabetes. Int J Psychiatry Med. 2016;51(1):3-15. Abstract

177. Elliott J, Jacques RM, Kruger J, et al. Substantial reductions in the number of diabetic ketoacidosis and severe hypoglycaemia episodes requiring emergency treatment lead to reduced costs after structured education in adults with Type 1 diabetes. Diabet Med. 2014 Jul;31(7):847-53.Full text  Abstract

178. Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.Full text  Abstract

Comorbidities Manager reference articles

179. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. Oct 2024 [internet publication].Full text

180. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. May 2017 [internet publication]Full text

181. Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

182. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Full text  Abstract

183. Royal College of Physicians. National early warning score (NEWS2). Standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication]Full text

184. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2025 [internet publication]Full text

185. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. Nov 2024 [internet publication]Full text

186. O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017 Jun;72(suppl 1):ii1-90Full text  Abstract

187. Chu DK, Kim LH, Young PJ, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): systematic review and meta-analysis. Lancet. 2018 Apr 26;391(10131):1693-705 Abstract

188. Siemieniuk RAC, Chu DK, Kim LH, et al. Oxygen therapy for acutely ill medical patients: a clinical practice guideline. BMJ. 2018 Oct 24;363:k4169. Abstract

189. NHS England. Toolkit for general practice in supporting older people living with frailty. March 2017 [internet publication]Full text

190. British Geriatrics Society (BGS), Getting It Right First Time (GIRFT). Six steps to better care for older people in acute hospitals. Jul 2023 [internet publication].Full text

191. Falk Erhag H, Guðnadóttir G, Alfredsson J, et al. The association between the clinical frailty scale and adverse health outcomes in older adults in acute clinical settings: a systematic review of the literature. Clin Interv Aging. 2023 Feb;18:249-61.Full text  Abstract

192. Quinn TJ, Mooijaart SP, Gallacher K, et al. Acute care assessment of older adults living with frailty. BMJ. 2019 Jan 31;364:l13 Abstract

193. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024 Apr;105(4s):S117-S314.Full text  Abstract

194. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Full text  Abstract

195. British Medical Association, the Resuscitation Council (UK) and the Royal College of Nursing. Decisions relating to cardiopulmonary resuscitation. 2016 [internet publication].Full text

196. The National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Full text

197. Office of the Public Guardian. Mental Capacity Act: making decisions. Jun 2023 [internet publication]Full text

198. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). January 2010 [internet publication]Full text

199. Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

200. Karslioglu French E, Donihi AC, Korytkowski MT. Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients. BMJ. 2019 May 29;365:l1114Full text  Abstract

201. Davies MJ, Aroda VR, Collins BS, et al. Management of hyperglycemia in type 2 diabetes, 2022: a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2022 Nov 1;45(11):2753-86.Full text  Abstract

202. Zhou Y, Wang FR, Wen FF, et al. The association between sodium/glucose cotransporter-2 inhibitors and adverse clinical events in patients with chronic kidney disease: a systematic review and meta-analysis of randomised controlled trials. Acta Cardiol. 2024 May;79(3):274-83. Abstract

203. UK Kidney Association. UK Kidney Association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease. April 2023 [internet publication].Full text

204. Joint British Diabetes Societies for Inpatient Care. The management of diabetes in adults and children with psychiatric disorders in inpatient settings. May 2017 [internet publication]Full text

205. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72 Abstract

206. National Institute for Health and Care Excellence. Hypertension in adults. Nov 2023 [internet publication].Full text

207. Griffin M, Rao VS, Ivey-Miranda J, et al. Empagliflozin in heart failure: diuretic and cardiorenal effects. Circulation. 2020 Sep 15;142(11):1028-39.Full text  Abstract

208. Law JP, Pickup L, Townend JN, et al. Anticoagulant strategies for the patient with chronic kidney disease. Clin Med (Lond). 2020 Mar;20(2):151-5Full text  Abstract

209. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Nov 9;6(12):681-94 Abstract

210. Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a stroke risk factor and determinant of outcome after stroke. Stroke. 2020 Oct;51(10):3156-68.Full text  Abstract

211. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13 Abstract

212. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 May 4;47(6):e98-e169Full text  Abstract

213. Pendlebury ST, Klaus SP, Mather M, et al. Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. Age Ageing. 2015 Oct 13;44(6):1000-5Full text  Abstract

214. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233-8 Abstract

215. Emery A, Wells J, Klaus SP, et al. Underestimation of cognitive impairment in older inpatients by the Abbreviated Mental Test Score versus the Montreal Cognitive Assessment: cross-sectional observational study. Dement Geriatr Cogn Dis Extra. 2020 Sep-Dec;10(3):205-15.Full text  Abstract

216. Scottish Intercollegiate Guidelines Network. Risk reduction and management of delirium. Mar 2019 [internet publication].Full text

217. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014 Mar 2;43(4):496-502.Full text  Abstract

218. National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. Jan 2023 [internet publication].Full text

219. Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021 May 5;50(3):733-43.Full text  Abstract

220. Zhang XM, Jiao J, Xie XH, et al. The association between frailty and delirium among hospitalized patients: an updated meta-analysis. J Am Med Dir Assoc. 2021 Mar;22(3):527-34. Abstract

221. National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. Jun 2018 [internet publication].Full text

222. Bishara D. Managing drugs with anticholinergic activity. Drug Ther Bull. 2023 Sep;61(9):135-9.Full text  Abstract

223. Lisibach A, Gallucci G, Benelli V, et al. Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients: a cohort study comparing 19 anticholinergic burden scales. Br J Clin Pharmacol. 2022 Nov;88(11):4915-27.Full text  Abstract

224. Smith H, Fligelstone H. Reducing patient and planetary harms from high anticholinergic burden medication. BMJ. 2024 Jan 15;384:e075708.Full text  Abstract

225. Gracie TJ, Caufield-Noll C, Wang NY, et al. The association of preoperative frailty and postoperative delirium: a meta-analysis. Anesth Analg. 2021 Aug 1;133(2):314-23.Full text  Abstract

226. Liu CY, Gong N, Liu W. The association between preoperative frailty and postoperative delirium: a systematic review and meta-analysis. J Perianesth Nurs. 2022 Feb;37(1):53-62.e1. Abstract

227. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Jan 11;74(3):357-72Full text  Abstract

228. Burton JK, Craig L, Yong SQ, et al. Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2021 Nov 26;(11):CD013307.Full text  Abstract

229. UK Health Security Agency. Urinary tract infection: diagnostic tools for primary care. Jul 2025 [internet publication]Full text

230. Medicines and Healthcare products Regulatory Agency. Haloperidol (haldol): reminder of risks when used in elderly patients for the acute treatment of delirium. Dec 2021 [internet publication]Full text

231. Mühlbauer V, Möhler R, Dichter MN, et al. Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2021 Dec 17;12(12):CD013304.Full text  Abstract

232. Yunusa I, Alsumali A, Garba AE, et al. Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. JAMA Netw Open. 2019 Mar 1;2(3):e190828.Full text  Abstract

233. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Mar 30;3:CD007726.Full text  Abstract

234. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Abstract

235. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Abstract

236. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Full text  Abstract

237. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Full text  Abstract

238. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2025 [internet publication].Full text

239. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Full text  Abstract

240. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. July 2019 [internet publication]Full text

241. National Institute for Health and Care Excellence. Depression in adults: treatment and management. Jun 2022 [internet publication]Full text

242. Horowitz M, Taylor DM. The Maudsley deprescribing guidelines: antidepressants, benzodiazepines, gabapentinoids and Z-drugs. Chichester: Wiley-Blackwell; 2024.

243. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 14th edition. Chichester: Wiley-Blackwell; 2021

244. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Full text  Abstract

245. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Abstract

246. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626 Abstract

247. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97Full text  Abstract

248. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40Full text  Abstract

249. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid. 2016 Jun;11(6)4-7Full text

250. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94 Abstract

251. Oliveira P, Ribeiro J, Donato H, Madeira N. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017;16:17Full text  Abstract

252. Roose SP, Rutherford BR. Selective serotonin reuptake inhibitors and operative bleeding risk: a review of the literature. J Clin Psychopharmacol. 2016 Dec;36(6):704-9 Abstract

253. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Full text

254. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Full text

255. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7 Abstract

256. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(S7):S54-60 Abstract

257. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Full text

258. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33Full text  Abstract

259. Archer G, Kuh D, Hotopf M, et al. Association between lifetime affective symptoms and premature mortality. JAMA Psychiatry. 2020 Aug 1;77(8):806-13Full text  Abstract

260. Machado MO, Veronese N, Sanches M, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018 Jul 20;16(1):112Full text  Abstract

261. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Feb 2025 [internet publication].Full text

262. Theodoulou A, Chepkin SC, Ye W, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;6(6):CD013308Full text  Abstract

263. Rigotti NA, Kruse GR, Livingstone-Banks J, et al. Treatment of tobacco smoking: a review. JAMA. 2022 Feb 8;327(6):566-77.Full text  Abstract

264. Agrawal S, Evison M, Ananth S, et al. Medical management of inpatients with tobacco dependency. Thorax. 2024 Mar 26;79(suppl 1):3-11.Full text  Abstract

265. Lindson N, Theodoulou A, Ordóñez-Mena JM, et al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses. Cochrane Database Syst Rev. 2023 Sep 12;9(9):CD015226.Full text  Abstract

266. Thomas KH, Dalili MN, López-López JA, et al. Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials. Addiction. 2022 Apr;117(4):861-76.Full text  Abstract

267. Livingstone-Banks J, Fanshawe TR, Thomas KH, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 June 28;6(6):CD006103Full text

268. Streck JM, Rigotti NA, Livingstone-Banks J, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024 May 21;5(5):CD001837.Full text  Abstract

269. Livingstone-Banks J, Vidyasagaran AL, Croucher R, et al. Interventions for smokeless tobacco use cessation. Cochrane Database Syst Rev. 2025 Apr 15;4(4):CD015314.Full text  Abstract

270. Hogervorst VM, Buurman BM, De Jonghe A, et al. Emergency department management of older people living with frailty: a guide for emergency practitioners. Emerg Med J. 2021 Sep;38(9):724-9 Abstract

271. British Geriatric Society, Centre for Perioperative Care. Guideline for the care of people living with frailty undergoing elective and emergency surgery that encompasses the whole perioperative pathway. Sep 2021 [internet publication].Full text

272. Rockwood K; British Geriatrics Society. Silver book II: frailty. February 2021 [internet publication]Full text

273. Conroy SP, Bardsley M, Smith P, et al. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study. Health Services and Delivery Research. 2019 April:7(15)Full text

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