Screening
There is no role for screening of the asymptomatic population.
Bone marrow failure syndromes
Due to the risk of developing AML and secondary malignancies, patients with inherited bone marrow failure syndromes (e.g., Fanconi's anaemia, Kostmann's syndrome, and Diamond-Blackfan anaemia) would benefit from regular full blood count (FBC) to screen for the development of myelodysplastic syndrome (MDS) or AML.[23]
Aplastic anaemia
It is recommended that patients with aplastic anaemia be followed up regularly (e.g., with FBC, immunophenotyping) to detect the development of clonal disorders such as paroxysmal nocturnal haemoglobinuria, MDS, or AML.[59] See Aplastic anaemia.
Autologous haematopoietic stem cell transplant recipients and patients treated with chemotherapy and/or radiotherapy
These patients are at increased risk for secondary malignancies (including AML). Regular monitoring with FBC and peripheral blood film, and early bone marrow investigation if AML is suspected, is recommended.[60]
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