Endometrial cancer

5-year survival

The 5-year survival rate for endometrial cancer (based on US data between 2015 and 2021) by stage at diagnosis is:[30]National Institutes of Health; Surveillance​, Epidemiology, and End Results Program. Cancer stat facts: uterine cancer. 2025 [internet publication]. https://seer.cancer.gov/statfacts/html/corp.html

• Localised (disease confined to the uterus): 95.1%

• Regional (disease spread regional lymph nodes): 70%

• Distant (metastatic disease): 19.4%

• Unknown (unstaged): 58.8%.

Most endometrial cancers are diagnosed at an early stage and successfully treated surgically. At diagnosis (based on US data between 2015 and 2021) 67% of cases are localised, 18% are regional, 11% are distant, and 4% are unstaged.[30]National Institutes of Health; Surveillance​, Epidemiology, and End Results Program. Cancer stat facts: uterine cancer. 2025 [internet publication]. https://seer.cancer.gov/statfacts/html/corp.html

Recurrence

Most recurrences (65% to 85%) occur within 3 years of treatment and are symptomatic.[9]Koskas M, Amant F, Mirza MR, et al. Cancer of the corpus uteri: 2021 update. Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(suppl 1):45-60. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.13866 http://www.ncbi.nlm.nih.gov/pubmed/34669196?tool=bestpractice.com ​ Recurrences for early-stage disease occur at the vaginal cuff and pelvis.