Epidemiology

The global incidence of endometrial cancer is increasing, which may be related to increased obesity prevalence.[28]

In 2022, there were approximately 420,000 new cases of endometrial cancer worldwide.[29]​ In the US, an estimated 69,120 new cases of uterine cancer, and 13,860 associated deaths, are expected in 2025.​​[30]

Median age at diagnosis is 64 years.[30]​ Based on US data from 2018 to 2022, the age-adjusted incidence is 28.3 cases per 100,000 women. Incidence for non-Hispanic white women and non-Hispanic black women is 27.6 cases per 100,000 and 30.6 cases per 100,000, respectively.[30]​ Black women are substantially less likely to be diagnosed with localised-stage disease than white women (56% vs. 72%, respectively)​.[31]

In Europe, an estimated 124,874 cases of endometrial cancer were diagnosed in 2022, with 30,272 deaths from this cancer.[32]​​ In the UK, uterine cancer is the fourth most common cancer in females, with approximately 9800 new cases diagnosed every year (2017-2019 data).[33]

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