Stomach cancer
- Overview
- Theory
- Diagnosis
- Management
- Follow up
- Resources
Primary prevention
There is some evidence that the long-term use of (low-dose) aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), and the eradication of Helicobacter pylori can decrease the risk of all gastrointestinal cancers.[11]Shah SC, Wang AY, Wallace MB, et al. AGA clinical practice update on screening and surveillance in individuals at increased risk for gastric cancer in the United States: expert review. Gastroenterology. 2025 Feb;168(2):405-16.e1.
https://www.gastrojournal.org/article/S0016-5085(24)05663-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/39718517?tool=bestpractice.com
[20]Choi IJ, Kim CG, Lee JY, et al. Family history of gastric cancer and helicobacter pylori treatment. N Engl J Med. 2020 Jan 30;382(5):427-36.
https://www.nejm.org/doi/10.1056/NEJMoa1909666
http://www.ncbi.nlm.nih.gov/pubmed/31995688?tool=bestpractice.com
[34]Brusselaers N, Lagergren J. Maintenance use of non-steroidal anti-inflammatory drugs and risk of gastrointestinal cancer in a nationwide population-based cohort study in Sweden. BMJ Open. 2018 Jul 7;8(7):e021869.
https://bmjopen.bmj.com/content/8/7/e021869.long
http://www.ncbi.nlm.nih.gov/pubmed/29982219?tool=bestpractice.com
[35]Ford AC, Yuan Y, Forman D, et al. Helicobacter pylori eradication for the prevention of gastric neoplasia. Cochrane Database Syst Rev. 2020 Jul 6;(7):CD005583.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005583.pub3/full
http://www.ncbi.nlm.nih.gov/pubmed/32628791?tool=bestpractice.com
[36]Bosetti C, Santucci C, Gallus S, et al. Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019. Ann Oncol. 2020 May;31(5):558-68.
https://www.annalsofoncology.org/article/S0923-7534(20)36073-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/32272209?tool=bestpractice.com
[37]Ford AC, Yuan Y, Park JY, et al. Eradication therapy to prevent gastric cancer in Helicobacterpylori-positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies. Gastroenterology. 2025 Aug;169(2):261-76.
https://www.gastrojournal.org/article/S0016-5085(25)00041-1/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/39824392?tool=bestpractice.com
[38]Shami JJP, Zhao J, Pathadka S, et al. Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study. BMJ Open. 2022 Feb 4;12(2):e050510.
https://bmjopen.bmj.com/content/12/2/e050510
http://www.ncbi.nlm.nih.gov/pubmed/35121597?tool=bestpractice.com
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