A prevalência de anorexia nervosa ao longo da vida nos EUA, de acordo com os critérios do DSM-5, é de aproximadamente 0.8%.[5]Udo T, Grilo CM. Prevalence and correlates of DSM-5-defined eating disorders in a nationally representative sample of U.S. adults. Biol Psychiatry. 2018 Sep 1;84(5):345-54.
http://www.ncbi.nlm.nih.gov/pubmed/29859631?tool=bestpractice.com
A prevalência da anorexia nervosa varia globalmente. Revisões sistemáticas que incluem uma série de estudos de todo o mundo estimam taxas gerais de prevalência ao longo da vida de 0.2%, sendo observadas taxas mais altas nos estudos que usam os critérios do DSM-5 (0.9%). Os estudos sobre a prevalência dos transtornos alimentares são limitados e concentrados na Europa, América, Austrália, Nova Zelândia, China e Coreia do Sul.[6]Qian J, Wu Y, Liu F, et al. An update on the prevalence of eating disorders in the general population: a systematic review and meta-analysis. Eat Weight Disord. 2022 Mar;27(2):415-28.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8933366
http://www.ncbi.nlm.nih.gov/pubmed/33834377?tool=bestpractice.com
A anorexia nervosa é mais estudada nos países desenvolvidos, onde o transtorno é mais comum.[7]Steiner H, Kwan W, Shaffer TG, et al. Risk and protective factors for juvenile eating disorders. Eur Child Adolesc Psychiatry. 2003;12(suppl 1):I38-46.
http://www.ncbi.nlm.nih.gov/pubmed/12567214?tool=bestpractice.com
[8]Nagel KL, Jones KH. Sociological factors in the development of eating disorders. Adolescence. 1992 Spring;27(105):107-13.
http://www.ncbi.nlm.nih.gov/pubmed/1539487?tool=bestpractice.com
Embora muito poucos indivíduos que fazem dieta na tentativa de perder peso desenvolvam anorexia nervosa, a doença ocorre com mais frequência nas culturas onde a busca pela magreza é valorizada. Estudos transculturais têm vinculado o aumento dos transtornos alimentares à exposição à mídia e aos ideais ocidentais, e há evidências de que as atitudes que podem aumentar o risco de transtornos alimentares estejam aumentando nos países não ocidentais.[9]Wu J, Liu J, Li S, et al. Trends in the prevalence and disability-adjusted life years of eating disorders from 1990 to 2017: results from the Global Burden of Disease Study 2017. Epidemiol Psychiatr Sci. 2020 Dec 7;29:e191.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7737181
http://www.ncbi.nlm.nih.gov/pubmed/33283690?tool=bestpractice.com
Vale ressaltar que as taxas de anorexia nos países asiáticos têm aumentado substancialmente desde 2000; as taxas da última década são agora comparáveis às observadas nos países ocidentais.[9]Wu J, Liu J, Li S, et al. Trends in the prevalence and disability-adjusted life years of eating disorders from 1990 to 2017: results from the Global Burden of Disease Study 2017. Epidemiol Psychiatr Sci. 2020 Dec 7;29:e191.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7737181
http://www.ncbi.nlm.nih.gov/pubmed/33283690?tool=bestpractice.com
[10]Kim YR, Nakai Y, Thomas JJ. Introduction to a special issue on eating disorders in Asia. Int J Eat Disord. 2021 Jan;54(1):3-6.
http://www.ncbi.nlm.nih.gov/pubmed/33340374?tool=bestpractice.com
[11]Nakai Y, Nin K, Goel NJ. The changing profile of eating disorders and related sociocultural factors in Japan between 1700 and 2020: A systematic scoping review. Int J Eat Disord. 2021 Jan;54(1):40-53.
http://www.ncbi.nlm.nih.gov/pubmed/33336841?tool=bestpractice.com
[12]van Eeden AE, van Hoeken D, Hoek HW. Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa. Curr Opin Psychiatry. 2021 Nov 1;34(6):515-24.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8500372
http://www.ncbi.nlm.nih.gov/pubmed/34419970?tool=bestpractice.com
É difícil obter dados epidemiológicos precisos, mas as melhores informações disponíveis indicam que a incidência de anorexia nervosa (número de novos diagnósticos por ano) não mudou substancialmente nas últimas três décadas.[12]van Eeden AE, van Hoeken D, Hoek HW. Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa. Curr Opin Psychiatry. 2021 Nov 1;34(6):515-24.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8500372
http://www.ncbi.nlm.nih.gov/pubmed/34419970?tool=bestpractice.com
[13]Smink FR, van Hoeken D, Donker GA, et al. Three decades of eating disorders in Dutch primary care: decreasing incidence of bulimia nervosa but not of anorexia nervosa. Psychol Med. 2016 Apr;46(6):1189-96.
http://www.ncbi.nlm.nih.gov/pubmed/26671456?tool=bestpractice.com
[14]Demmler JC, Brophy ST, Marchant A, et al. Shining the light on eating disorders, incidence, prognosis and profiling of patients in primary and secondary care: national data linkage study. Br J Psychiatry. 2020 Feb;216(2):105-12.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7557634
http://www.ncbi.nlm.nih.gov/pubmed/31256764?tool=bestpractice.com
[15]Reas DL, Rø Ø. Time trends in healthcare-detected incidence of anorexia nervosa and bulimia nervosa in the Norwegian National Patient Register (2010-2016). Int J Eat Disord. 2018 Oct;51(10):1144-52.
http://www.ncbi.nlm.nih.gov/pubmed/30265747?tool=bestpractice.com
No entanto, há evidências que sugerem um aumento na incidência em crianças (idade <15 anos), em particular crianças mais novas (idade ≤12 anos) nos anos mais recentes.[16]Halmi KA, Casper RC, Eckert ED, et al. Unique features associated with age of onset of anorexia nervosa. Psychiatr Res. 1979 Oct;1(2):209-15.
http://www.ncbi.nlm.nih.gov/pubmed/298349?tool=bestpractice.com
[17]Petkova H, Simic M, Nicholls D, et al. Incidence of anorexia nervosa in young people in the UK and Ireland: a national surveillance study. BMJ Open. 2019 Oct 22;9(10):e027339.
https://bmjopen.bmj.com/content/9/10/e027339.long
http://www.ncbi.nlm.nih.gov/pubmed/31640991?tool=bestpractice.com
[18]Silén Y, Sipilä PN, Raevuori A, et al. DSM-5 eating disorders among adolescents and young adults in Finland: a public health concern. Int J Eat Disord. 2020 May;53(5):520-31.
http://www.ncbi.nlm.nih.gov/pubmed/31999001?tool=bestpractice.com
[19]Cybulski L, Ashcroft DM, Carr MJ, et al. Temporal trends in annual incidence rates for psychiatric disorders and self-harm among children and adolescents in the UK, 2003-2018. BMC Psychiatry. 2021 May 3;21(1):229.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8092997
http://www.ncbi.nlm.nih.gov/pubmed/33941129?tool=bestpractice.com
O início antes dos 15 anos de idade está associado a uma maior gravidade da doença e a maiores taxas de comorbidades psiquiátricas ao longo da vida.[20]Grilo CM, Udo T. Examining the significance of age of onset in persons with lifetime anorexia nervosa: comparing child, adolescent, and emerging adult onsets in nationally representative U.S. study. Int J Eat Disord. 2021 Sep;54(9):1632-40.
http://www.ncbi.nlm.nih.gov/pubmed/34263464?tool=bestpractice.com
De acordo com critérios de diagnóstico rigorosos, aproximadamente 0.3% das pessoas nos países ocidentalizados, sendo cerca de 0.5% a 1% de mulheres em idade universitária, são afetadas.[21]Hoek HW. Incidence, prevalence and mortality of anorexia nervosa and other eating disorders. Curr Opin Psychiatry. 2006 Jul;19(4):389-94.
http://www.ncbi.nlm.nih.gov/pubmed/16721169?tool=bestpractice.com
[22]Miller KK, Grinspoon SK, Ciampa J, et al. Medical findings in outpatients with anorexia nervosa. Arch Intern Med. 2005 Mar 14;165(5):561-6.
http://www.ncbi.nlm.nih.gov/pubmed/15767533?tool=bestpractice.com
Estima-se que 3 em cada 10 pacientes sejam do sexo masculino, mas muitos deles podem não procurar tratamento; portanto, aproximadamente 90% dos pacientes diagnosticados são do sexo feminino.[15]Reas DL, Rø Ø. Time trends in healthcare-detected incidence of anorexia nervosa and bulimia nervosa in the Norwegian National Patient Register (2010-2016). Int J Eat Disord. 2018 Oct;51(10):1144-52.
http://www.ncbi.nlm.nih.gov/pubmed/30265747?tool=bestpractice.com
[18]Silén Y, Sipilä PN, Raevuori A, et al. DSM-5 eating disorders among adolescents and young adults in Finland: a public health concern. Int J Eat Disord. 2020 May;53(5):520-31.
http://www.ncbi.nlm.nih.gov/pubmed/31999001?tool=bestpractice.com
Alguns relatos têm sugerido que a prevalência relativa da anorexia nervosa entre meninos pré-adolescentes se aproxima de uma razão de meninos para meninas de 1:4.[23]Bryan-Waugh R, Lask B. Childhood-onset eating disorders. In: Fairburn GC, Brownell KD, eds. Eating disorders and obesity: a comprehensive handbook. 2nd ed. New York: Guilford Press, 2002:210-4. Os homens podem ter menos probabilidade de serem diagnosticados, possivelmente por subnotificação dos sintomas e menor grau de suspeita entre os profissionais de saúde.[24]Raevuori A, Keski-Rahkonen A, Hoek HW. A review of eating disorders in males. Curr Opin Psychiatry. 2014 Nov;27(6):426-30.
http://www.ncbi.nlm.nih.gov/pubmed/25226158?tool=bestpractice.com
O risco de início de uma anorexia nervosa é maior no final da adolescência, sendo que 40% dos casos novos ocorrem em pacientes entre 15 e 19 anos de idade.[13]Smink FR, van Hoeken D, Donker GA, et al. Three decades of eating disorders in Dutch primary care: decreasing incidence of bulimia nervosa but not of anorexia nervosa. Psychol Med. 2016 Apr;46(6):1189-96.
http://www.ncbi.nlm.nih.gov/pubmed/26671456?tool=bestpractice.com
[17]Petkova H, Simic M, Nicholls D, et al. Incidence of anorexia nervosa in young people in the UK and Ireland: a national surveillance study. BMJ Open. 2019 Oct 22;9(10):e027339.
https://bmjopen.bmj.com/content/9/10/e027339.long
http://www.ncbi.nlm.nih.gov/pubmed/31640991?tool=bestpractice.com
[18]Silén Y, Sipilä PN, Raevuori A, et al. DSM-5 eating disorders among adolescents and young adults in Finland: a public health concern. Int J Eat Disord. 2020 May;53(5):520-31.
http://www.ncbi.nlm.nih.gov/pubmed/31999001?tool=bestpractice.com
O risco de desenvolver anorexia nervosa diminui significativamente após os 21 anos de idade, embora haja sugestões de que o período da menopausa seja um período adicional de alto risco nas mulheres para o início ou recorrência de um transtorno alimentar.[25]Mangweth-Matzek B, Hoek HW. Epidemiology and treatment of eating disorders in men and women of middle and older age. Curr Opin Psychiatry. 2017 Nov;30(6):446-51.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5690315
http://www.ncbi.nlm.nih.gov/pubmed/28825955?tool=bestpractice.com
[26]Samuels KL, Maine MM, Tantillo M. Disordered eating, eating disorders, and body image in midlife and older women. Curr Psychiatry Rep. 2019 Jul 1;21(8):70.
http://www.ncbi.nlm.nih.gov/pubmed/31264039?tool=bestpractice.com
Somente um terço das pessoas com anorexia nervosa busca assistência médica.[27]Coffino JA, Udo T, Grilo CM. Rates of help-seeking in US adults with lifetime DSM-5 eating disorders: prevalence across diagnoses and differences by sex and ethnicity/race. Mayo Clin Proc. 2019 Aug;94(8):1415-26.
http://www.ncbi.nlm.nih.gov/pubmed/31324401?tool=bestpractice.com
Alguns estudos indicam que as mulheres brancas têm maior probabilidade de serem diagnosticadas com anorexia nervosa do que as mulheres de outros grupos étnicos e raciais, embora as evidências sejam mistas.[5]Udo T, Grilo CM. Prevalence and correlates of DSM-5-defined eating disorders in a nationally representative sample of U.S. adults. Biol Psychiatry. 2018 Sep 1;84(5):345-54.
http://www.ncbi.nlm.nih.gov/pubmed/29859631?tool=bestpractice.com
[28]Cheng ZH, Perko VL, Fuller-Marashi L, et al. Ethnic differences in eating disorder prevalence, risk factors, and predictive effects of risk factors among young women. Eat Behav. 2019 Jan;32:23-30.
https://www.sciencedirect.com/science/article/abs/pii/S1471015318300928?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/30529736?tool=bestpractice.com
[29]Marques L, Alegria M, Becker AE, et al. Comparative prevalence, correlates of impairment, and service utilization for eating disorders across US ethnic groups: implications for reducing ethnic disparities in health care access for eating disorders. Int J Eat Disord. 2011 Jul;44(5):412-20.
http://www.ncbi.nlm.nih.gov/pubmed/20665700?tool=bestpractice.com
A prevalência parece maior em pessoas que se identificam como lésbicas, gays, bissexuais, transgêneros, homossexuais ou questionadoras (LGBTQ+), em comparação com pares heterossexuais/cisgêneros.[30]Kamody RC, Grilo CM, Udo T. Disparities in DSM-5 defined eating disorders by sexual orientation among U.S. adults. Int J Eat Disord. 2020 Feb;53(2):278-87.
http://www.ncbi.nlm.nih.gov/pubmed/31670848?tool=bestpractice.com
[31]Nagata JM, Ganson KT, Austin SB. Emerging trends in eating disorders among sexual and gender minorities. Curr Opin Psychiatry. 2020 Nov;33(6):562-7.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8060208
http://www.ncbi.nlm.nih.gov/pubmed/32858597?tool=bestpractice.com
Entre as doenças psiquiátricas, a anorexia nervosa apresenta uma das maiores taxas de mortalidade prematura (com um risco de morte prematura aproximadamente cinco vezes maior que o de pares).[32]Franko DL, Keshaviah A, Eddy KT, et al. A longitudinal investigation of mortality in anorexia nervosa and bulimia nervosa. Am J Psychiatry. 2013 Aug;170(8):917-25.
https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.12070868
http://www.ncbi.nlm.nih.gov/pubmed/23771148?tool=bestpractice.com
[33]van Hoeken D, Hoek HW. Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden. Curr Opin Psychiatry. 2020 Nov;33(6):521-7.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7575017
http://www.ncbi.nlm.nih.gov/pubmed/32796186?tool=bestpractice.com
As principais causas de morte são complicações clinicas ou suicídio.[34]Auger N, Potter BJ, Ukah UV, et al. Anorexia nervosa and the long-term risk of mortality in women. World Psychiatry. 2021 Oct;20(3):448-9.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8429328
http://www.ncbi.nlm.nih.gov/pubmed/34505367?tool=bestpractice.com
[35]Nielsen S, Vilmar JW. What can we learn about eating disorder mortality from eating disorder diagnoses at initial assessment? A Danish nationwide register follow-up study using record linkage, encompassing 45 years (1970-2014). Psychiatry Res. 2021 Sep;303:114091.
https://www.sciencedirect.com/science/article/abs/pii/S0165178121003887?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/34246009?tool=bestpractice.com
Quadros psiquiátricos concomitantes são comuns e podem aumentar o risco de mortalidade, inclusive o risco de suicídio. As comorbidades incluem depressão, ansiedade, transtorno do estresse pós-traumático, transtorno obsessivo-compulsivo, transtorno de deficit de atenção com hiperatividade e transtornos por uso de substâncias.[36]Ahn J, Lee JH, Jung YC. Predictors of suicide attempts in individuals with eating disorders. Suicide Life Threat Behav. 2019 Jun;49(3):789-97.
https://www.doi.org/10.1111/sltb.12477
http://www.ncbi.nlm.nih.gov/pubmed/29882994?tool=bestpractice.com
[37]Cliffe C, Shetty H, Himmerich H, et al. Suicide attempts requiring hospitalization in patients with eating disorders: a retrospective cohort study. Int J Eat Disord. 2020 May;53(5):458-65.
http://www.ncbi.nlm.nih.gov/pubmed/32043625?tool=bestpractice.com
[38]Keski-Rahkonen A. Epidemiology of binge eating disorder: prevalence, course, comorbidity, and risk factors. Curr Opin Psychiatry. 2021 Nov 1;34(6):525-31.
http://www.ncbi.nlm.nih.gov/pubmed/34494972?tool=bestpractice.com
A presença de diabetes concomitante aumenta substancialmente o risco de morte em comparação com as pessoas com diabetes sem nenhum transtorno alimentar.[39]Gibbings NK, Kurdyak PA, Colton PA, et al. Diabetic ketoacidosis and mortality in people with type 1 diabetes and eating disorders. Diabetes Care. 2021 Aug;44(8):1783-7.
https://diabetesjournals.org/care/article/44/8/1783/138813/Diabetic-Ketoacidosis-and-Mortality-in-People-With
http://www.ncbi.nlm.nih.gov/pubmed/34172488?tool=bestpractice.com