Monitoring
If non-motor symptoms (NMS) of RLS (pain, sleep, mood, anxiety) are part of the clinical presentation, they can be monitored using the revised NMS Questionnaire (NMSQuest) validated for Parkinson's disease.[51]
In patients with iron deficiency on oral iron supplementation, ferritin should be rechecked after 3-4 months, and then every 3-6 months until serum ferritin is >225 picomols/L (>100 nanograms/mL). If there is no ongoing cause for iron deficiency, treatment can be stopped. It should restart if RLS worsens, unless serum ferritin is ≥674 picomols/L (≥300 nanograms/mL) (the usually accepted safe upper limit).
Patients on levodopa/carbidopa or dopamine agonists should be monitored for signs of augmentation and impulse control disorders.[26]
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