References
Key articles
Seaton E, Madan V. Benign keratinocytic acanthomas and proliferations. In: Barker J, Griffiths C, Bleiker T, eds. Rook's textbook of dermatology. 10th ed. Hoboken, NJ: John Wiley & Sons, Ltd; 2024.
Patterson JW. Chapter 32: Tumors of the epidermis. In: Patterson JW. Weedon's skin pathology. 6th ed. Philadelphia, PA: Elsevier; 2025: 877-936.
Barthelmann S, Butsch F, Lang BM, et al. Seborrheic keratosis. J Dtsch Dermatol Ges. 2023 Mar;21(3):265-77.Full text Abstract
Reference articles
1. Seaton E, Madan V. Benign keratinocytic acanthomas and proliferations. In: Barker J, Griffiths C, Bleiker T, eds. Rook's textbook of dermatology. 10th ed. Hoboken, NJ: John Wiley & Sons, Ltd; 2024.
2. Patterson JW. Chapter 32: Tumors of the epidermis. In: Patterson JW. Weedon's skin pathology. 6th ed. Philadelphia, PA: Elsevier; 2025: 877-936.
3. Yeatman JM, Kilkenny M, Marks R. The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency? Br J Dermatol. 1997;137:411-414. Abstract
4. Gorai S, Ahmad S, Raza SSM, et al. Update of pathophysiology and treatment options of seborrheic keratosis. Dermatol Ther. 2022 Dec;35(12):e15934.Full text Abstract
5. Holdiness MR. On the classification of the sign of Leser-Trelat. J Am Acad Dermatology. 1988;19:754-757. Abstract
6. Schwartz RA. Sign of Leser-Trelat. J Am Acad Dermatol. 1996;35:88-95. Abstract
7. Barthelmann S, Butsch F, Lang BM, et al. Seborrheic keratosis. J Dtsch Dermatol Ges. 2023 Mar;21(3):265-77.Full text Abstract
8. Mirali S, Mufti A, Lansang RP, et al. Eruptive seborrheic keratoses are associated with a co-occurring malignancy in the majority of reported cases: a systematic review. J Cutan Med Surg. 2022 Jan-Feb;26(1):57-62.Full text Abstract
9. Augustin M, Herberger K, Hintzen S, et al. Prevalence of skin lesions and need for treatment in a cohort of 90 880 workers. Br J Dermatol. 2011 Oct;165(4):865-73.Full text Abstract
10. Du Y, Doraiswamy C, Mao J, et al. Facial skin characteristics and concerns in Indonesia: a cross-sectional observational study. Skin Res Technol. 2022 Sep;28(5):719-28.Full text Abstract
11. Jackson JM, Alexis A, Berman B, et al. Current understanding of seborrheic keratosis: prevalence, etiology, clinical presentation, diagnosis, and management. J Drugs Dermatol. 2015 Oct;14(10):1119-25. Abstract
12. Bhat RM, Patrao N, Monteiro R, et al. A clinical, dermoscopic, and histopathological study of dermatosis papulosa nigra (DPN) - an Indian perspective. Int J Dermatol. 2017 Sep;56(9):957-60. Abstract
13. Cheong KA, Lee AY. Guanine deaminase stimulates ultraviolet-induced keratinocyte senescence in seborrhoeic keratosis via guanine metabolites. Acta Derm Venereol. 2020 Apr 6;100(8):adv00109.Full text Abstract
14. Xie F, Wang R, Chen Y, et al. A case of seborrhoeic keratosis and family survey. West Indian Med J. 2015 May 11;65(1):219-21.Full text Abstract
15. Nakamura H, Hirota S, Adachi S, et al. Clonal nature of seborrheic keratosis demonstrated by using the polymorphism of the human androgen receptor locus as a marker. J Invest Dermatol. 2001 Apr;116(4):506-10.Full text Abstract
16. Rayess H, Wang MB, Srivatsan ES. Cellular senescence and tumor suppressor gene p16. Int J Cancer. 2012 Apr 15;130(8):1715-25.Full text Abstract
17. Alexandrova AK, Smolyannikova VA, Filatova VA, et al. Protein p16 role in seborrheic keratosis. Our Dermatol Online. 2016;7(4):377-380.Full text
18. Li Y, Wang Y, Zhang W, et al. Overexpression of amyloid precursor protein promotes the onset of seborrhoeic keratosis and is related to skin ageing. Acta Derm Venereol. 2018 Jun 8;98(6):594-600.Full text Abstract
19. Kwon OS, Hwang EJ, Bae JH, et al. Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed. 2003;19:73-80. Abstract
20. Hafner C, Hartmann A, van Oers JM, et al. FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Mod Pathol. 2007;20:895-903. Abstract
21. Kambiz KH, Kaveh D, Maede D, et al. Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction. Indian J Dermatol. 2014 Jul;59(4):334-8.Full text Abstract
22. Huang J, Zhang L, Shi L, et al. An epidemiological study on skin tumors of the elderly in a community in Shanghai, China. Sci Rep. 2023 Mar 17;13(1):4441.Full text Abstract
23. Garcia MS, Azari R, Eisen DB. Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. Dermatol Surg. 2010 Dec;36(12):1968-72. Abstract
24. National Institute for Health and Care Excellence. Melanoma: assessment and management. Jul 2022 [internet publication].Full text
25. Tschandl P, Codella N, Akay BN, et al. Comparison of the accuracy of human readers versus machine-learning algorithms for pigmented skin lesion classification: an open, web-based, international, diagnostic study. Lancet Oncol. 2019 Jul;20(7):938-947.Full text Abstract
26. Braun RP, Rabinovitz HS, Krischer J, et al. Dermoscopy of pigmented seborrheic keratosis: a morphological study. Arch Dermatol. 2002;138:1556-60.Full text Abstract
27. Ahlgrimm-Siess V, Cao T, Oliviero M, et al. Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy. J Am Acad Dermatol. 2013;69:120-6. Abstract
28. Wollina U. Recent advances in managing and understanding seborrheic keratosis. F1000Res. 2019 Aug 28;8:F1000 Faculty Rev-1520.Full text Abstract
29. Bafounta ML, Beauchet A, Aegerter P, et al. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol. 2001;137:1343-1350. Abstract
30. Wang SQ, Rabinovitz H, Oliviero MC. Dermoscopic patterns of solar lentigines and seborrheic keratoses. Braun. In: Marghoob AA, Braun RP, Kopf AW, eds. Atlas of dermoscopy. London: Taylor and Francis; 2005:60-71.
31. Izikson L, Sober AJ, Mihm MC Jr, et al. Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. Arch Dermatol. 2002;138:1562-1566.Full text Abstract
32. Vinciullo C, Madan V. Basal cell carcinoma. In: Griffiths C E M, Barker J, Bleiker T O, eds. Rook's textbook of dermatology. 10th ed. Hoboken, NJ: John Wiley & Sons Ltd; 2024.
33. Cranwell WC, Sinclair R. Optimising cryosurgery technique. Aust Fam Physician. 2017;46(5):270-4. Abstract
34. Wood LD, Stucki JK, Hollenbeak CS, et al. Effectiveness of cryosurgery vs curettage in the treatment of seborrheic keratoses. JAMA Dermatol. 2013;149:108-109.Full text Abstract
35. Mardani G, Nasiri MJ, Namazi N, et al. Treatment of solar lentigines: a systematic review of clinical trials. J Cosmet Dermatol. 2025 Apr;24(4):e70133.Full text Abstract
36. Natarelli N, Krenitsky A, Hennessy K, et al. Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review. J Dermatolog Treat. 2023 Dec;34(1):2133532.Full text Abstract
37. Ortonne JP, Pandya AG, Lui H, et al. Treatment of solar lentigines. J Am Acad Dermatol. 2006;54(suppl 2):S262-71. Abstract
38. Krupashankar DS; IADVL Dermatosurgery Task Force. Standard guidelines of care: CO2 laser for removal of benign skin lesions and resurfacing. Indian J Dermatol Venereol Leprol. 2008;74(suppl):S61-7.Full text Abstract
39. Polder KD, Landau JM, Vergilis-Kalner IJ, et al. Laser eradication of pigmented lesions: a review. Dermatol Surg. 2011;37:572-595. Abstract
40. Jain S, Caire H, Haas CJ. Management of dermatosis papulosa nigra: a systematic review. Int J Dermatol. 2025 Mar;64(3):473-8. Abstract
41. Murphy EC, Friedman AJ. Hydrogen peroxide topical solution, 40% (w/w) for the treatment of seborrheic keratoses: a review. Skin Therapy Lett. 2020 Jan;25(1):1-4.Full text Abstract
42. Baumann LS, Blauvelt A, Draelos ZD, et al. Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302). J Am Acad Dermatol. 2018 Jun 1;79(5):869-877.Full text Abstract
43. Funkhouser CH, Coerdt KM, Haidari W, et al. Hydrogen peroxide 40% for the treatment of seborrheic keratoses. Ann Pharmacother. 2021 Feb;55(2):216-221. Abstract
44. Taylor SC, Averyhart AN, Heath CR. Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. J Am Acad Dermatol. 2011 Mar;64(3 suppl):S30-5.Full text Abstract
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