Emerging treatments
Platelet-rich plasma
Use of platelet-rich plasma (and/or related growth factors) may help with healing after anterior cruciate ligament (ACL) reconstruction; however, results are mixed. One study showed a significant beneficial effect on graft-bone interface healing following ACL reconstruction, but no significant benefit in terms of clinical outcomes, and another showed no significant improvements of knee symptoms and function at 12 months.[98][99] One Cochrane review concluded that there is insufficient evidence to support their use.[100]
Bridge-enhanced techniques
The bridge-enhanced ACL repair (BEAR) uses a collagen scaffold in between the torn ends of the ACL to help with the healing process. Results from a study of 100 participants comparing BEAR with autograft ACL reconstruction showed no significant difference in knee function between the two groups at 2 years postoperatively.[101] Further analysis of the results showed an earlier resolution of symptoms and increased satisfaction about knee function earlier during the 2-year follow-up period for the BEAR patient group.[102]
Novel arthroscopic suture anchors
Some investigators are looking at other forms of direct repair of torn ACLs, with improved surgical technique and use of newer suture anchors.[103]
Tranexamic acid before and during surgical reconstruction
One clinical trial showed that intravenous administration of tranexamic acid in the pre- and peri-operative period of arthroscopic ACL reconstruction surgery significantly decreased post-operative pain, hemarthrosis, and the need for joint aspiration with no increase in DVT or other adverse outcomes.[104]
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