Complications

Complication
Timeframe
Likelihood
short term
medium

Acute cortisol deficiency can occur: following pituitary apoplexy; or if the patient experiences vomiting and is unable to keep their oral hydrocortisone dose down.

If adrenal crisis is suspected, an immediate injection of hydrocortisone should be given. Older adults are at higher risk.[59]

variable
high

In men with secondary hypogonadism who desire fertility, treatment with gonadotropins is recommended.

These drugs should only be utilized by experienced practitioners, and advice should be sought from a specialist.

variable
high

In women with secondary hypogonadism who desire fertility, treatment with gonadotropins is recommended.

These drugs should only be utilized by experienced practitioners, and advice should be sought from a reproductive endocrinologist.

variable
medium

Can result from corticosteroid over-replacement.[74]

variable
medium

Can result from corticosteroid or growth hormone over-replacement.

variable
medium

Can result from corticosteroid, growth hormone, or testosterone over-replacement.

variable
medium

Can result from corticosteroid over-replacement. Glucose intolerance can result from growth hormone over-replacement.[3]

variable
medium

Can result from levothyroxine and corticosteroid over-replacement.[3]

variable
medium

Can result from levothyroxine over-replacement.[3]

variable
medium

Can result from desmopressin over-replacement, leading to life-threatening hyponatremia.[3]

variable
medium

Can result from growth hormone over-replacement.[3]

variable
medium

Can result from growth hormone over-replacement.

variable
medium

Can result from testosterone over-replacement.

variable
medium

Can result from testosterone over-replacement.

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