Functional outcomes
A significant proportion of patients may still complain of stiffness (as high as 63% in one study), pain, and swelling, with differences in fracture pattern potentially playing a role.[66]Hancock MJ, Herbert RD, Stewart M. Prediction of outcome after ankle fracture. J Orthop Sports Phys Ther. 2005;35:786-792.
http://www.ncbi.nlm.nih.gov/pubmed/16848099?tool=bestpractice.com
[67]Shah NH, Sundaram RO, Velusamy A, et al. Five-year functional outcome analysis of ankle fracture fixation. Injury. 2007;38:1308-1312.
http://www.ncbi.nlm.nih.gov/pubmed/17888434?tool=bestpractice.com
There is insufficient evidence to support the recommendation of a particular patient reported outcome measure (PROM) for use in adult ankle fracture research based on Consensus Based Standards for the Selection of Health Measurement Instrument (COSMIN) methodology.[68]McKeown R, Ellard DR, Rabiu AR, et al. A systematic review of the measurement properties of patient reported outcome measures used for adults with an ankle fracture. J Patient Rep Outcomes. 2019 Dec 17;3(1):70.
https://jpro.springeropen.com/articles/10.1186/s41687-019-0159-5
http://www.ncbi.nlm.nih.gov/pubmed/31848877?tool=bestpractice.com
Short musculoskeletal functional assessment/American Orthopedic Foot and Ankle Society Ankle Score
Using the short musculoskeletal functional assessment and the American Orthopedic Foot and Ankle Society Ankle Score, those with operatively treated bimalleolar fractures have poorer functional outcome than those with operatively treated lateral malleolar fractures and medial deltoid ligament rupture at 1 year.[69]Tejwani NC, McLaurin TM, Walsh M, et al. Are outcomes of bimalleolar fractures poorer than those of lateral malleolar fractures with medial ligamentous injury? J Bone Joint Surg Am. 2007;89:1438-1441.
http://www.ncbi.nlm.nih.gov/pubmed/17606780?tool=bestpractice.com
Similarly, it has been reported that patients with a younger age, male sex, and the absence of diabetes mellitus have improved functional recovery at 1 year following operative stabilization of ankle fractures.[70]Egol KA, Tejwani NC, Walsh MG, et al. Predictors of short-term functional outcome following ankle fracture surgery. J Bone Joint Surg Am. 2006;88:974-979.
http://www.ncbi.nlm.nih.gov/pubmed/16651571?tool=bestpractice.com
There may also be a trend toward earlier functional recovery following operative ankle fracture stabilization with early functional rehabilitation.[44]Petrisor BA, Poolman R, Koval K, et al. Management of displaced ankle fractures. J Orthop Trauma. 2006;20:515-518.
http://www.ncbi.nlm.nih.gov/pubmed/16891946?tool=bestpractice.com
[71]Dehghan N, McKee MD, Jenkinson RJ, et al. Early weightbearing and range of motion versus non-weightbearing and immobilization after open reduction and internal fixation of unstable ankle fractures: a randomized controlled trial. J Orthop Trauma. 2016 Jul;30(7):345-52.
http://www.ncbi.nlm.nih.gov/pubmed/27045369?tool=bestpractice.com
In those patients with operatively treated syndesmotic injuries, anatomic reduction of the syndesmosis may lead to improved functional recovery as measured by the short musculoskeletal functional assessment questionnaire.[13]Weening B, Bhandari M. Predictors of functional outcome following transsyndesmotic screw fixation of ankle fractures. 2005;19:102-108.
http://www.ncbi.nlm.nih.gov/pubmed/15677926?tool=bestpractice.com
SF-36
In those patients with operatively treated unstable ankle fractures there is a consistent improvement of health outcomes as measured by the SF-36 functional outcome score up to 2 years following injury.[72]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
[73]Obremskey WT, Dirschl DR, Crowther JD, et al. Change over time of SF-36 functional outcomes for operatively treated unstable ankle fractures. J Orthop Trauma. 2002;16:30-33.
http://www.ncbi.nlm.nih.gov/pubmed/11782630?tool=bestpractice.com
[74]Nilsson G, Jonsson K, Ekdahl C, et al. Outcome and quality of life after surgically treated ankle fractures in patients 65 years or older. BMC Musculoskelet Disord. 2007;8:127.
http://www.biomedcentral.com/1471-2474/8/127
http://www.ncbi.nlm.nih.gov/pubmed/18096062?tool=bestpractice.com
However, at 2 years subscores of the SF-36 in the physical function domain may remain less than population norms.[72]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
Studies suggest that patients who smoke, have a lower level of education, and present with a medial malleolar fracture report lower physical function following operatively treated unstable ankle fractures.[72]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
Poorer results as regards longer in-hospital stays and postoperative complications have also been identified in people with diabetes mellitus with operatively treated ankle fractures across all fracture morphologies.[75]Ganesh SP, Pietrobon R, Cecilio WA, et al. The impact of diabetes on patient outcomes after ankle fracture. J Bone Joint Surg Am. 2005;87:1712-1718.
http://www.ncbi.nlm.nih.gov/pubmed/16085609?tool=bestpractice.com