Functional outcomes
A significant proportion of patients may still complain of stiffness (as high as 63% in one study), pain, and swelling, with differences in fracture pattern potentially playing a role.[65]Hancock MJ, Herbert RD, Stewart M. Prediction of outcome after ankle fracture. J Orthop Sports Phys Ther. 2005;35:786-792.
http://www.ncbi.nlm.nih.gov/pubmed/16848099?tool=bestpractice.com
[66]Shah NH, Sundaram RO, Velusamy A, et al. Five-year functional outcome analysis of ankle fracture fixation. Injury. 2007;38:1308-1312.
http://www.ncbi.nlm.nih.gov/pubmed/17888434?tool=bestpractice.com
There is insufficient evidence to support the recommendation of a particular patient reported outcome measure (PROM) for use in adult ankle fracture research based on Consensus Based Standards for the Selection of Health Measurement Instrument (COSMIN) methodology.[67]McKeown R, Ellard DR, Rabiu AR, et al. A systematic review of the measurement properties of patient reported outcome measures used for adults with an ankle fracture. J Patient Rep Outcomes. 2019 Dec 17;3(1):70.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917678
http://www.ncbi.nlm.nih.gov/pubmed/31848877?tool=bestpractice.com
Short musculoskeletal functional assessment/American Orthopedic Foot and Ankle Society Ankle Score
Using the short musculoskeletal functional assessment and the American Orthopedic Foot and Ankle Society Ankle Score, those with operatively-treated bimalleolar fractures have poorer functional outcome than those with operatively-treated lateral malleolar fractures and medial deltoid ligament rupture at 1 year.[68]Tejwani NC, McLaurin TM, Walsh M, et al. Are outcomes of bimalleolar fractures poorer than those of lateral malleolar fractures with medial ligamentous injury? J Bone Joint Surg Am. 2007;89:1438-1441.
http://www.ncbi.nlm.nih.gov/pubmed/17606780?tool=bestpractice.com
Similarly, it has been reported that patients with a younger age, male sex, and the absence of diabetes mellitus have improved functional recovery at 1 year following operative stabilisation of ankle fractures.[69]Egol KA, Tejwani NC, Walsh MG, et al. Predictors of short-term functional outcome following ankle fracture surgery. J Bone Joint Surg Am. 2006;88:974-979.
http://www.ncbi.nlm.nih.gov/pubmed/16651571?tool=bestpractice.com
There may also be a trend towards earlier functional recovery following operative ankle fracture stabilisation with early functional rehabilitation.[40]Petrisor BA, Poolman R, Koval K, et al. Management of displaced ankle fractures. J Orthop Trauma. 2006;20:515-518.
http://www.ncbi.nlm.nih.gov/pubmed/16891946?tool=bestpractice.com
[70]Dehghan N, McKee MD, Jenkinson RJ, et al. Early weightbearing and range of motion versus non-weightbearing and immobilization after open reduction and internal fixation of unstable ankle fractures: a randomized controlled trial. J Orthop Trauma. 2016 Jul;30(7):345-52.
http://www.ncbi.nlm.nih.gov/pubmed/27045369?tool=bestpractice.com
In those patients with operatively treated syndesmotic injuries, anatomical reduction of the syndesmosis may lead to improved functional recovery as measured by the short musculoskeletal functional assessment questionnaire.[13]Weening B, Bhandari M. Predictors of functional outcome following transsyndesmotic screw fixation of ankle fractures. 2005;19:102-108.
http://www.ncbi.nlm.nih.gov/pubmed/15677926?tool=bestpractice.com
SF-36
In those patients with operatively-treated unstable ankle fractures there is a consistent improvement of health outcomes as measured by the SF-36 functional outcome score up to 2 years following injury.[71]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
[72]Obremskey WT, Dirschl DR, Crowther JD, et al. Change over time of SF-36 functional outcomes for operatively treated unstable ankle fractures. J Orthop Trauma. 2002;16:30-33.
http://www.ncbi.nlm.nih.gov/pubmed/11782630?tool=bestpractice.com
[73]Nilsson G, Jonsson K, Ekdahl C, et al. Outcome and quality of life after surgically treated ankle fractures in patients 65 years or older. BMC Musculoskelet Disord. 2007;8:127.
http://www.biomedcentral.com/1471-2474/8/127
http://www.ncbi.nlm.nih.gov/pubmed/18096062?tool=bestpractice.com
However, at 2 years sub-scores of the SF-36 in the physical function domain may remain less than population norms.[71]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
Studies suggest that patients who smoke, have a lower level of education, and present with a medial malleolar fracture report lower physical function following operatively treated unstable ankle fractures.[71]Bhandari M, Sprague S, Hanson B, et al. Health-related quality of life following operative treatment of unstable ankle fractures: a prospective observational study. J Orthop Trauma. 2004;18:338-345.
http://www.ncbi.nlm.nih.gov/pubmed/15213498?tool=bestpractice.com
Poorer results with regard to longer in-hospital stays and postoperative complications have also been identified in people with diabetes mellitus with operatively treated ankle fractures across all fracture morphologies.[74]Ganesh SP, Pietrobon R, Cecilio WA, et al. The impact of diabetes on patient outcomes after ankle fracture. J Bone Joint Surg Am. 2005;87:1712-1718.
http://www.ncbi.nlm.nih.gov/pubmed/16085609?tool=bestpractice.com