Emerging treatments
OBI-3424
OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.[173] AKR1C3 is upregulated in certain tumor cell types, but not expressed in normal healthy cells. OBI-3424 has received Food and Drug Administration (FDA) designation as an orphan drug for the treatment of T-ALL. One phase 2 clinical trial is recruiting.[174]
Inotuzumab ozogamicin plus TKI (for relapsed or refractory Ph+ ALL)
In a phase 1/2 trial, inotuzumab ozogamicin with bosutinib resulted in an objective response rate of 81% in 18 patients (16 patients with relapsed-refractory Ph+ B-ALL and 2 with chronic myeloid leukemia in lymphoid blast phase).[175]
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