AA is a common disorder with an estimated prevalence of 1 in 1000 people and a worldwide lifetime incidence of around 2%, which is similar to that reported in the US population.[2]Cranwell WC, Lai VW, Photiou L, et al. Treatment of alopecia areata: An Australian expert consensus statement. Australas J Dermatol. 2019 May;60(2):163-170.
https://www.doi.org/10.1111/ajd.12941
http://www.ncbi.nlm.nih.gov/pubmed/30411329?tool=bestpractice.com
[4]Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397-403.
https://www.doi.org/10.2147/CCID.S53985
http://www.ncbi.nlm.nih.gov/pubmed/26244028?tool=bestpractice.com
[5]Safavi KH, Muller SA, Suman VJ, et al. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70:628-633.
http://www.ncbi.nlm.nih.gov/pubmed/7791384?tool=bestpractice.com
It affects both sexes equally and is seen in all age groups with no known ethnic predominance. Incidence is higher in children and young adults.[6]Price VH. Treatment of hair loss. N Engl J Med. 1999;341:964-973.
http://www.ncbi.nlm.nih.gov/pubmed/10498493?tool=bestpractice.com
Patients usually present with several episodes of hair loss and hair regrowth during their lifetime. The course is irregular and unpredictable. The recovery from hair loss may be complete, partial, or none. The incidence of the severe chronic form of the condition is 7% to 10% in affected people.[7]Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. 2000;42:549-566.
http://www.ncbi.nlm.nih.gov/pubmed/10727299?tool=bestpractice.com
Indicators of a poor prognosis are the presence of other immune diseases, family history, young age at onset, nail dystrophy, extensive hair loss, and ophiasis (hair loss at the inferior hair line of the scalp [i.e., inferior-parietal/occipital scalp]).[2]Cranwell WC, Lai VW, Photiou L, et al. Treatment of alopecia areata: An Australian expert consensus statement. Australas J Dermatol. 2019 May;60(2):163-170.
https://www.doi.org/10.1111/ajd.12941
http://www.ncbi.nlm.nih.gov/pubmed/30411329?tool=bestpractice.com
[8]Hordinsky MK. Medical treatment of noncicatricial alopecia. Semin Cutan Med Surg. 2006;25:51-55.
http://www.ncbi.nlm.nih.gov/pubmed/16616303?tool=bestpractice.com
Atopy may be an indicator of poor prognosis, but recent evidence is lacking.[2]Cranwell WC, Lai VW, Photiou L, et al. Treatment of alopecia areata: An Australian expert consensus statement. Australas J Dermatol. 2019 May;60(2):163-170.
https://www.doi.org/10.1111/ajd.12941
http://www.ncbi.nlm.nih.gov/pubmed/30411329?tool=bestpractice.com