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Malignant hyperthermia

Diagnostic pathway for investigation of MH susceptibility. IVCT, in vitro contracture test; MH, malignant hyperthermia; MHN (MH negative or normal), classification applied when all contracture tests are negative; MHShc, MHSh, and MHSc, classifications are applied when contracture responses to both halothane and caffeine are abnormal, response to halothane alone is abnormal, or response to caffeine alone is abnormal, respectively. MHShc, MHSh, and MHSc patients should be asked to take part in research studies of the genetic basis of malignant hyperthermia

Hopkins PM et al. Br J Anaesth. 2015 Oct;115(4):531-9. Used with permission

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Malignant hyperthermia

The mechanical response of normal and MH-susceptible muscle (positive) to direct stimulation in the presence of incremental administration of caffeine

From the collection of Dr Sheila Muldoon

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Malignant hyperthermia

The mechanical response of normal and MH-susceptible muscle (positive) to direct stimulation in the presence of 3% halothane

From the collection of Dr Sheila Muldoon

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