Emerging treatments

Other pharmacologic agents

Haloperidol, a first-generation antipsychotic, has been used successfully in some cases of chronic hiccups.[39] However, it is limited by its side effects of central nervous system depression, orthostasis, and extrapyramidal effects at high doses. Gabapentin, an anticonvulsant, has also shown therapeutic efficacy in the treatment of hiccups.[4][40][41][42][43] Both haloperidol and gabapentin are promising drugs for treating chronic hiccups, but further clinical trials are needed.

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