Tumour lysis syndrome

SIGNS / SYMPTOMS

Also associated with malignancy, particularly haematological malignancies.[34]Jones DP, Mahmoud H, Chesney RW. Tumor lysis syndrome: pathogenesis and management. Pediatr Nephrol. 1995 Apr;9(2):206-12. http://www.ncbi.nlm.nih.gov/pubmed/7794722?tool=bestpractice.com [52]Cohen LF, Balow JE, Magrath IT, et al. Acute tumor lysis syndrome. A review of 37 patients with Burkitt's lymphoma. Am J Med.1980 Apr;68(4):486-91. http://www.ncbi.nlm.nih.gov/pubmed/7369230?tool=bestpractice.com [53]Krakoff IH, Murphy ML. Hyperuricemia in neoplastic disease in children: prevention with allopurinol, a xanthine oxidase inhibitor. Pediatrics. 1968 Jan;41(1):52-6. http://www.ncbi.nlm.nih.gov/pubmed/5635486?tool=bestpractice.com

May be asymptomatic or present with nephrolithiasis or gout.

SIGNS / SYMPTOMS

Patient may be taking potassium-sparing medication, systemic heparin, or non-steroidal anti-inflammatory drugs. Renal failure and frequent blood transfusions can contribute.[54]Yarpuzlu A. A review of clinical and laboratory findings and treatment of tumor lysis syndrome. Clin Chim Acta. 2003 Jul 1;333(1):13-8. http://www.ncbi.nlm.nih.gov/pubmed/12809731?tool=bestpractice.com

SIGNS / SYMPTOMS

History of dehydration and volume depletion, pulmonary embolism, bone metastases, or advanced renal failure.[54]Yarpuzlu A. A review of clinical and laboratory findings and treatment of tumor lysis syndrome. Clin Chim Acta. 2003 Jul 1;333(1):13-8. http://www.ncbi.nlm.nih.gov/pubmed/12809731?tool=bestpractice.com Use of bisphosphonates, laxatives, and antacids may contribute. 

SIGNS / SYMPTOMS

Perioral numbness or tingling.