The estimated prevalence of hyperhidrosis ranges from 2% to 16% globally. This may be due to differences in methodology, diagnostic criteria, demographics, or geography.[3]Strutton DR, Kowalski JW, Glaser DA, et al. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8.
http://www.ncbi.nlm.nih.gov/pubmed/15280843?tool=bestpractice.com
[4]Liu Y, Bahar R, Kalia S, et al. Hyperhidrosis prevalence and demographical characteristics in dermatology outpatients in Shanghai and Vancouver. PLoS One. 2016;11(4):e0153719.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153719
http://www.ncbi.nlm.nih.gov/pubmed/27105064?tool=bestpractice.com
[5]Doolittle J, Walker P, Mills T, et al. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016 Dec;308(10):743-49.
https://link.springer.com/article/10.1007/s00403-016-1697-9
http://www.ncbi.nlm.nih.gov/pubmed/27744497?tool=bestpractice.com
The estimated prevalence of hyperhidrosis in the US ranges from 2.8% to 4.8%, with approximately half of these people having the axillary variety.[3]Strutton DR, Kowalski JW, Glaser DA, et al. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8.
http://www.ncbi.nlm.nih.gov/pubmed/15280843?tool=bestpractice.com
[5]Doolittle J, Walker P, Mills T, et al. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016 Dec;308(10):743-49.
https://link.springer.com/article/10.1007/s00403-016-1697-9
http://www.ncbi.nlm.nih.gov/pubmed/27744497?tool=bestpractice.com
Approximately 50% of patients with palmar hyperhidrosis have a family history of the disorder.[6]Ro KM, Cantor RM, Lange KL, et al. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg. 2002 Feb;35(2):382-6.
http://www.jvascsurg.org/article/S0741-5214%2802%2994862-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/11854739?tool=bestpractice.com
[7]Higashimoto I, Yoshiura K, Hirakawa N, et al. Primary palmar hyperhidrosis locus maps to 14q11.2-q13. Am J Med Genet A. 2006 Mar 15;140(6):567-72.
http://www.ncbi.nlm.nih.gov/pubmed/16470694?tool=bestpractice.com
There is no obvious sex predisposition.[3]Strutton DR, Kowalski JW, Glaser DA, et al. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8.
http://www.ncbi.nlm.nih.gov/pubmed/15280843?tool=bestpractice.com
[8]Shargall Y, Spratt E, Zeldin RA. Hyperhidrosis: what is it and why does it occur? Thorac Surg Clin. 2008 May;18(2):125-32.
http://www.ncbi.nlm.nih.gov/pubmed/18557586?tool=bestpractice.com
Primary hyperhidrosis has a bimodal onset commonly starting in early childhood or at puberty.[2]Solish N, Wang R, Murray CA. Evaluating the patient presenting with hyperhidrosis. Thorac Surg Clin. 2008 May;18(2):133-40.
http://www.ncbi.nlm.nih.gov/pubmed/18557587?tool=bestpractice.com
[8]Shargall Y, Spratt E, Zeldin RA. Hyperhidrosis: what is it and why does it occur? Thorac Surg Clin. 2008 May;18(2):125-32.
http://www.ncbi.nlm.nih.gov/pubmed/18557586?tool=bestpractice.com
[9]Baumgartner FJ, Bertin S, Konecny J. Superiority of thoracoscopic sympathectomy over medical management for the palmoplantar subset of severe hyperhidrosis. Ann Vasc Surg. 2009 Jan-Feb;23(1):1-7.
http://www.ncbi.nlm.nih.gov/pubmed/18619780?tool=bestpractice.com
Of patients with severe hyperhidrosis presenting for surgery, most have palmoplantar hyperhidrosis, 15% to 20% have combined palmar-axillary hyperhidrosis, 5% to 10% have isolated axillary hyperhidrosis, and less than 5% have craniofacial hyperhidrosis.[10]Eisenach JH, Atkinson JL, Fealey RD. Hyperhidrosis: evolving therapies for a well-established phenomenon. Mayo Clin Proc. 2005 May;80(5):657-66.
http://www.mayoclinicproceedings.org/article/S0025-6196(11)63098-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/15887434?tool=bestpractice.com