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Last reviewed: 21 Apr 2025
Last updated: 24 Nov 2023

Summary

Definition

History and exam

Key diagnostic factors

  • history of coronary artery disease
  • history of hypertrophic cardiomyopathy
  • history of idiopathic dilated cardiomyopathy
  • presence of other risk factors
  • asymptomatic presentation
  • tachycardia

Other diagnostic factors

  • palpitations
  • dizziness
  • lightheadedness
  • pre-syncope
  • syncope

Risk factors

  • coronary artery disease
  • left ventricular systolic dysfunction
  • hypertrophic cardiomyopathy
  • idiopathic dilated cardiomyopathy
  • long QT syndrome
  • Brugada's syndrome
  • electrolyte imbalance
  • drug toxicity
  • Chagas' disease and other cardiomyopathies
  • sleep-disordered breathing
  • catecholaminergic polymorphic VT
  • family history of sudden death
  • mental or physical stress

Diagnostic investigations

1st investigations to order

  • ECG
  • electrolyte panel
  • troponin
  • CK-MB

Investigations to consider

  • 24-hour ambulatory ECG monitoring
  • echocardiogram
  • cardiac catheterisation
  • cardiac MRI with gadolinium
  • electrophysiological testing
  • stress testing
  • genetic screening

Treatment algorithm

Contributors

Authors

Fred Kusumoto, MD
Fred Kusumoto

Professor of Medicine

Mayo Medical School

Division of Cardiovascular Diseases

Department of Medicine

Mayo Clinic Florida

Jacksonville

FL

Disclosures

FK declares that he has no competing interests.

Acknowledgements

Professor Kusumoto would like to gratefully acknowledge Dr Ronald R. Butendieck Jr, a previous contributor to this topic.

Disclosures

RRB declares that he has no competing interests.

Peer reviewers

Timothy Markman, MD

Assistant Professor of Medicine

Hospital of the University of Pennsylvania

Philadelphia

PA

Disclosures

TM declares that he has no competing interests.

Vias Markides, MB(Hons), BS(Hons), MD, FRCP

Consultant Cardiologist and Chair

Arrhythmias

Royal Brompton & Harefield NHS Trust

Hon. Senior Lecturer

Imperial College

London

UK

Disclosures

VM declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2018 Sep 25;138(13):e272-e391.Full text  Abstract

Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022 Oct 21;43(40):3997-4126.Full text  Abstract

Katritsis DG, Zareba W, Camm AJ. Nonsustained ventricular tachycardia. J Am Coll Cardiol. 2012 Nov 13;60(20):1993-2004.Full text  Abstract

Goldberger JJ, Cain ME, Hohnloser SH, et al. American Heart Association/American College of Cardiology/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. Circulation. 2008 Sep 30;118(14):1497-1518. Abstract

Epstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: executive summary. Circulation. 2008 Jun;117(6):e350-408.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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