Folate deficiency

Pfeiffer CM, Sternberg MR, Zhang M, et al. Folate status in the US population 20 y after the introduction of folic acid fortification. Am J Clin Nutr. 2019 Nov 1;110(5):1088-97.Full text  Abstract

Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008 Jun;29(2 suppl):S20-34. Abstract

Whitehead VM. Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol. 2006 Jul;134(2):125-36.Full text  Abstract

MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 1991 Jul 20;338(8760):131-7. Abstract

1. Green R, Datta Mitra A. Megaloblastic anemias: nutritional and other causes. Med Clin North Am. 2017 Mar;101(2):297-317. Abstract

2. Aslinia F, Mazza JJ, Yale SH. Megaloblastic anemia and other causes of macrocytosis. Clin Med Res. 2006 Sep;4(3):236-41.Full text  Abstract

3. McLean E, de Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull. 2008 Jun;29(2 suppl):S38-51. Abstract

4. Metz J. Haematological implications of folate food fortification. S Afr Med J. 2013 Oct 11;103(12 Suppl 1):978-81. Abstract

5. Rogers LM, Cordero AM, Pfeiffer CM, et al. Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues. Ann N Y Acad Sci. 2018 Nov;1431(1):35-57.Full text  Abstract

6. Quinn M, Halsey J, Sherliker P, et al. Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: a systematic review. EClinicalMedicine. 2024 Jan;67:102366.Full text  Abstract

7. Pfeiffer CM, Sternberg MR, Zhang M, et al. Folate status in the US population 20 y after the introduction of folic acid fortification. Am J Clin Nutr. 2019 Nov 1;110(5):1088-97.Full text  Abstract

8. Colapinto CK, O'Connor DL, Tremblay MS. Folate status of the population in the Canadian Health Measures Survey. CMAJ. 2011 Feb 8;183(2):E100-6.Full text  Abstract

9. Antony AC. Evidence for potential underestimation of clinical folate deficiency in resource-limited countries using blood tests. Nutr Rev. 2017 Aug 1;75(8):600-15. Abstract

10. Antony AC, Vora RM, Karmarkar SJ. The silent tragic reality of Hidden Hunger, anaemia, and neural-tube defects (NTDs) in India. Lancet Reg Health Southeast Asia. 2022 Nov;6:100071.Full text  Abstract

11. Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008 Jun;29(2 suppl):S20-34. Abstract

12. Whitehead VM. Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol. 2006 Jul;134(2):125-36.Full text  Abstract

13. Htet MK, Fahmida U, Thurnham DI, et al. Folate and vitamin B12 status and dietary intake of anaemic adolescent schoolgirls in the delta region of Myanmar. Br J Nutr. 2015 Jul;116(suppl 1):S36-41. Abstract

14. Sevitt LH, Hoffbrand AV. Serum folate and vitamin B12 levels in acute and chronic renal disease. Effect of peritoneal dialysis. Br Med J. 1969 Apr 5;2(5648):18-21.Full text  Abstract

15. Tu YR, Tu KH, Lee CC, et al. Supplementation with folic acid and cardiovascular outcomes in end-stage kidney disease: a multi-institution cohort study. Nutrients. 2022 Oct 7;14(19):4162.Full text  Abstract

16. Nazki FH, Sameer AS, Ganaie BA. Folate: metabolism, genes, polymorphisms and the associated diseases. Gene. 2014 Jan 1;533(1):11-20. Abstract

17. Koury MJ. Abnormal erythropoiesis and the pathophysiology of chronic anemia. Blood Rev. 2014 Mar;28(2):49-66. Abstract

18. Balashova OA, Visina O, Borodinsky LN. Folate action in nervous system development and disease. Dev Neurobiol. 2018 Apr;78(4):391-402.Full text  Abstract

19. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 1991 Jul 20;338(8760):131-7. Abstract

20. Ramakrishnan U, Grant F, Goldenberg T, et al. Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol. 2012 Jul;26(suppl 1):285-301. Abstract

21. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992 Dec 24;327(26):1832-5.Full text  Abstract

22. Medici V, Peerson JM, Stabler SP, et al. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol. 2010 Sep;53(3):551-7.Full text  Abstract

23. Gloria L, Cravo M, Camilo ME, et al. Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption. Am J Gastroenterol. 1997 Mar;92(3):485-9. Abstract

24. Mackey AD, Picciano MF. Maternal folate status during extended lactation and the effect of supplemental folic acid. Am J Clin Nutr. 1999 Feb;69(2):285-92.Full text  Abstract

25. Wald NJ. Folic acid and neural tube defects: discovery, debate and the need for policy change. J Med Screen. 2022 Sep;29(3):138-46.Full text  Abstract

26. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000 May;71(5 suppl):1295S-303S. Abstract

27. Ek J, Magnus EM. Plasma and red blood cell folate in breastfed infants. Acta Paediatr Scand. 1979 Mar;68(2):239-43. Abstract

28. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002 Jun;132(6 Suppl 1):1395S-577S. Abstract

29. Jyothi S, Misra I, Morris G, et al. Red cell folate and plasma homocysteine in preterm infants. Neonatology. 2007;92(4):264-8. Abstract

30. Carmel R. Megaloblastic anemias: disorders of impaired DNA synthesis. In: Greer JP, Foerster J, Lukens JN, et al, eds. Wintrobe's clinical hematology. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004:1372-482.

31. Bledsoe AC, King KS, Larson JJ, et al. Micronutrient deficiencies are common in contemporary celiac disease despite lack of overt malabsorption symptoms. Mayo Clin Proc. 2019 Jul;94(7):1253-60. Abstract

32. Wani NA, Hamid A, Kaur J. Folate status in various pathophysiological conditions. IUBMB Life. 2008 Dec;60(12):834-42. Abstract

33. National Institutes of Health. Folate: fact sheet for health professionals. ​Nov 2022 [internet publication].Full text

34. Wilson RD, O'Connor DL. Guideline no. 427: folic acid and multivitamin supplementation for prevention of folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can. 2022 Jun;44(6):707-19. Abstract

35. US Preventive Services Task Force, Barry MJ, Nicholson WK, et al. Folic acid supplementation to prevent neural tube defects: US Preventive Services Task Force reaffirmation recommendation statement. JAMA. 2023 Aug 1;330(5):454-9.Full text  Abstract

36. Public Health England. Folic acid: updated SACN recommendations. Jul 2017 [internet publication].Full text

37. U.S. Preventive Services Task Force. ​Folic acid supplementation to prevent neural tube defects: preventive medication. Aug 2023 [internet publication].Full text

38. Cordero AM, Crider KS, Rogers LM, et al. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines. MMWR Morb Mortal Wkly Rep. 2015 Apr 24;64(15):421-3. Abstract

39. National Institute for Health and Care Excellence. Maternal and child nutrition: nutrition and weight management in pregnancy, and nutrition in children up to 5 years. Jan 2025 [internet publication].Full text

40. Bulloch RE, Wall CR, Thompson JMD, et al. Folic acid supplementation is associated with size at birth in the Screening for Pregnancy Endpoints (SCOPE) international prospective cohort study. Early Hum Dev. 2020 Aug;147:105058. Abstract

41. Lassi ZS, Salam RA, Haider BA, et al. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD006896.Full text  Abstract

42. Balogun OO, da Silva Lopes K, Ota E, et al. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev. 2016 May 6;(5):CD004073.Full text  Abstract

43. Keats EC, Haider BA, Tam E, et al. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019 Mar 14;(3):CD004905.Full text  Abstract

44. Herbert V. Experimental nutritional folate deficiency in man. Trans Assoc Am Physicians. 1962;75:307-20. Abstract

45. Lin Y, Dueker SR, Follett JR, et al. Quantitation of in vivo human folate metabolism. Am J Clin Nutr. 2004 Sep;80(3):680-91.Full text  Abstract

46. Green R. Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies. Food Nutr Bull. 2008 Jun;29(2 suppl):S52-63. Abstract

47. Galloway M, Rushworth L. Red cell or serum folate? Results from the National Pathology Alliance benchmarking review. J Clin Pathol. 2003 Dec;56(12):924-6.Full text  Abstract

48. Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014 Aug;166(4):496-513.Full text  Abstract

49. Savage DG, Lindenbaum J, Stabler SP, et al. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med. 1994 Mar;96(3):239-46. Abstract

50. Selhub J, Jacques PF, Dallal G, et al. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr Bull. 2008 Jun;29(2 suppl):S67-73. Abstract

51. Hussein WI, Green R, Jacobsen DW, et al. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med. 1999 Sep 7;131(5):348-51. Abstract

52. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014 May;44(5):480-8. Abstract

53. Stover PJ, Durga J, Field MS. Folate nutrition and blood-brain barrier dysfunction. Curr Opin Biotechnol. 2017 Apr;44:146-52.Full text  Abstract

54. Cordero JF, Do A, Berry RJ. Review of interventions for the prevention and control of folate and vitamin B12 deficiencies. Food Nutr Bull. 2008 Jun;29(2 suppl):S188-95. Abstract

55. Russel A, Statter M, Abzug S. Methionine-dependent formiminoglutamic acid transferase deficiency: human and experimental studies in its therapy. Hum Hered. 1977;27:205.

56. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med. 1999 Jun 28;159(12):1289-98.Full text  Abstract

57. Patel A, Chanarin I. Restoration of normal red cell size after treatment in megaloblastic anaemia. Br J Haematol. 1975 May;30(1):57-63. Abstract

58. Liu L, Liu S, Wang C, et al. Folate supplementation for methotrexate therapy in patients with rheumatoid arthritis: a systematic review. J Clin Rheumatol. 2019 Aug;25(5):197-202. Abstract

59. National Institute for Health and Care Excellence. BNF for children treatment summaries. Anaemia, megaloblastic. 2019 [internet publication].Full text

60. Goh YI, Koren G. Folic acid in pregnancy and fetal outcomes. J Obstet Gynaecol. 2008 Jan;28(1):3-13. Abstract

61. Beaudin AE, Stover PJ. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol. 2009 Apr;85(4):274-84. Abstract

62. Selhub J. Public health significance of elevated homocysteine. Food Nutr Bull. 2008 Jun;29(suppl 2):S116-25. Abstract

63. Carmel R, Green R, Rosenblatt DS, et al. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program. 2003;2003:62-81.Full text  Abstract

64. American Academy of Family Physicians. Summary of recommendations for clinical preventive services. Jul 2017 [internet publication].Full text

65. Mei W, Rong Y, Jinming L, et al. Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials. Int J Clin Pract. 2010 Jan;64(2):208-15. Abstract

66. Ross JF, Belding H, Paegel BL. The development and progression of subacute combined degeneration of the spinal cord in patients with pernicious anemia treated with synthetic pteroylglutamic (folic) acid. Blood. 1948 Jan;3(1):68-90. Abstract

67. Reynolds EH. What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies. Eur J Clin Nutr. 2016 May;70(5):537-40. Abstract

68. Patel KR, Sobczyńska-Malefora A. The adverse effects of an excessive folic acid intake. Eur J Clin Nutr. 2017 Feb;71(2):159-63. Abstract

69. Belbasis L, Köhler CA, Stefanis N, et al. Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: an umbrella review of meta-analyses. Acta Psychiatr Scand. 2018 Feb;137(2):88-97. Abstract

70. Firth J, Carney R, Stubbs B, et al. Nutritional deficiencies and clinical correlates in first-episode psychosis: a systematic review and meta-analysis. Schizophr Bull. 2018 Oct 17;44(6):1275-92.Full text  Abstract

71. Roffman JL, Lamberti JS, Achtyes E, et al. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry. 2013 May;70(5):481-9.Full text  Abstract

72. Ramaekers VT, Sequeira JM, Quadros EV. The basis for folinic acid treatment in neuro-psychiatric disorders. Biochimie. 2016 Jul;126:79-90. Abstract

73. Selhub J, Rosenberg IH. Public health significance of supplementation or fortification of grain products with folic acid. Food Nutr Bull. 2008 Jun;29(2 suppl):S173-6. Abstract