Criteria
Musculoskeletal Tumor Society (MSTS) staging system[31]
The MSTS surgical staging system is frequently used for bone sarcomas and defines grades of non-metastatic malignant bone tumours.
I-A: low-grade, intra-compartmental
I-B: low-grade, extra-compartmental
II-A: high-grade, intra-compartmental
II-B: high-grade, extra-compartmental
III: any grade, metastatic.
American Joint Committee on Cancer TNM staging system (8th Edition)[32]
The American Joint Committee on Cancer (AJCC) staging system describes the extent of disease based on the following anatomical factors: size and extent of the primary tumour (T); regional lymph node involvement (N); and presence or absence of distant metastases (M). Non-anatomical prognostic factors (e.g., tumour grade, biomarkers) may be used to supplement the staging of certain cancers.
National Comprehensive Cancer Network (NCCN)[23]
The NCCN practice guidelines describe 5 subtypes.
High-grade, intra-medullary + surface
Low-grade, intra-medullary + surface
Periosteal
Metastatic disease at presentation
Extraskeletal (see Soft-tissue sarcoma)
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