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Last reviewed: 21 Apr 2025
Last updated: 17 Apr 2025

Summary

Definition

History and exam

Key diagnostic factors

  • severe episodic headache
  • nausea and vomiting
  • light and noise sensitivity
  • functional impact
  • aura symptoms
  • throbbing character

Risk factors

  • family history of migraine
  • female sex and hormonal changes
  • poor sleep quality
  • stress
  • medication overuse
  • periodic syndromes

Diagnostic investigations

Investigations to consider

  • brain MRI
  • electroencephalogram
  • lumbar puncture
  • erythrocyte sedimentation rate (ESR) and CRP
  • head CT

Treatment algorithm

Contributors

Authors

Cristian Ionita, MD

Associate Professor of Clinical Pediatrics (Neurology)

Yale School of Medicine

New Haven

CT

Disclosures

CI declares that he has no competing interests.

Acknowledgements

Dr Christian Ionita would like to gratefully acknowledge Dr Nick Barnes, a previous contributor to this topic.

Disclosures

NB declares that he has no competing interests.

Peer reviewers

Kenneth Mack, MD, PhD

Medical Director

Mayo Clinic Pediatric Center

Rochester

MN

Disclosures

KM declares that he has no competing interests.

Tony McShane, MBBS

Consultant Paediatric Neurologist

John Radcliffe Hospital

Oxford

UK

Disclosures

TM declares that he has no competing interests.

Sandeep Jayawant, MBBS

Consultant Paediatric Neurologist

John Radcliffe Hospital

Oxford

UK

Disclosures

SJ declares that he has no competing interests.

Howard S. Jacobs, MD

Associate Professor

Co-Director Pediatric Headache Clinic

University of Maryland School of Medicine

Baltimore

MD

Disclosures

HSJ declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211.Full text  Abstract

Oskoui M, Pringsheim T, Billinghurst L, et al. Practice guideline update summary: pharmacologic treatment for pediatric migraine prevention. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):500-9.Full text  Abstract

Oskoui M, Pringsheim T, Holler-Managan Y, et al. Practice guideline update summary: acute treatment of migraine in children and adolescents. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):487-99.Full text  Abstract

Richer L, Billinghurst L, Linsdell MA, et al. Drugs for the acute treatment of migraine in children and adolescents. Cochrane Database Syst Rev. 2016 Apr 19;(4):CD005220.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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