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Last reviewed: 21 Apr 2025
Last updated: 21 May 2024

Summary

Definition

History and exam

Key diagnostic factors

  • scarred uterus
  • presence of other risk factors
  • painless vaginal bleeding
  • absence of cervical/vaginal causes of bleeding on speculum examination

Other diagnostic factors

  • previous ultrasound anomaly in first trimester
  • lack of uterine tenderness
  • low blood pressure and tachycardia

Risk factors

  • advanced maternal age
  • multiple previous pregnancies
  • smoking
  • previous miscarriage
  • previous induced abortion
  • other placental abnormalities
  • short inter-pregnancy intervals
  • illicit drug use
  • uterine scarring (most commonly due to prior caesarean section)
  • infertility treatments
  • prior placenta praevia

Diagnostic investigations

1st investigations to order

  • uterine ultrasound with colour flow Doppler analysis
  • FBC
  • type and cross-match

Investigations to consider

  • MRI placenta
  • INR/PTT, fibrinogen, and fibrinogen degradation products
  • Kleihauer-Betke test

Treatment algorithm

Contributors

Authors

Janet R. Albers, MD
Janet R. Albers

Professor

Department Chair

Family and Community Medicine

Southern Illinois University School of Medicine

Springfield

IL

Disclosures

JRA declares that she has no competing interests.

Thomas H. Miller, MD

Professor

Clinical Family and Community Medicine

Associate Chairman - Western Region

Southern Illinois University School of Medicine

Springfield

IL

Disclosures

THM declares that he has no competing interests.

Acknowledgements

Dr Janet R. Albers and Dr Thomas H. Miller would like to gratefully acknowledge Dr Robert Ewart and Dr Matthew Hagermeyer, previous contributors to this topic.

Disclosures

RE and MH declare that they have no competing interests.

Peer reviewers

Yosra Tahir Jarjees, MD

Assistant Professor

Head of Department of Obstetrics and Gynecology

Mosul College of Medicine

Mosul

Iraq

Disclosures

YTJ declares that he has no competing interests.

John Bachman, MD

Consultant in Family Medicine

Parker D Sanders and Isabella Sanders Professor of Primary Care

Rochester

MN

Disclosures

JB declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Jain V, Bos H, Bujold E; Society of Obstetricians and Gynaecologists of Canada. Guideline no. 402: diagnosis and management of placenta previa. J Obstet Gynaecol Can. 2020 Jul;42(7):906-17.e1. Abstract

Royal College of Obstetricians and Gynaecologists. Placenta praevia and placenta accreta: diagnosis and management. Green-top guideline no. 27a. Sep 2018 [internet publication].Full text

American College of Obstetricians and Gynecologists / Society for Maternal-Fetal Medicine. ACOG SMFM obstetric care consensus #7: placenta accreta spectrum. Dec 2018 [internet publication].Full text

Shipp TD, Poder L, Feldstein VA, et al; Expert Panel on GYN and OB Imaging, American College of Radiology. ACR appropriateness criteria: second and third trimester vaginal bleeding. J Am Coll Radiol. 2020 Nov;17(11s):S497-504.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available here.

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